| Glucose transporters and insulin action—implications for insulin resistance and diabetes mellitus PR Shepherd, BB Kahn New England journal of medicine 341 (4), 248-257, 1999 | 1985 | 1999 |
| The TSC1-2 tumor suppressor controls insulin–PI3K signaling via regulation of IRS proteins LS Harrington, GM Findlay, A Gray, T Tolkacheva, S Wigfield, H Rebholz, ... The Journal of cell biology 166 (2), 213-223, 2004 | 1385 | 2004 |
| Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling PR Shepherd, DJ Withers, K Siddle Biochemical Journal 333 (3), 471-490, 1998 | 1259 | 1998 |
| Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on … BT Navé, DM Ouwens, DJ Withers, DR Alessi, PR SHEPHERD Biochemical Journal 344 (2), 427-431, 1999 | 1240 | 1999 |
| PI 3-kinase p110β: a new target for antithrombotic therapy SP Jackson, SM Schoenwaelder, I Goncalves, WS Nesbitt, CL Yap, ... Nature medicine 11 (5), 507-514, 2005 | 739 | 2005 |
| Adipose cell hyperplasia and enhanced glucose disposal in transgenic mice overexpressing GLUT4 selectively in adipose tissue. PR Shepherd, L Gnudi, E Tozzo, H Yang, F Leach, BB Kahn Journal of Biological Chemistry 268 (30), 22243-22246, 1993 | 655 | 1993 |
| The global burden of cancer attributable to risk factors, 2010–19: a systematic analysis for the Global Burden of Disease Study 2019 KB Tran, JJ Lang, K Compton, R Xu, AR Acheson, HJ Henrikson, ... The Lancet 400 (10352), 563-591, 2022 | 570 | 2022 |
| Exercise increases muscle GLUT-4 levels and insulin action in subjects with impaired glucose tolerance VA Hughes, MA Fiatarone, RA Fielding, BB Kahn, CM Ferrara, ... American Journal of Physiology-Endocrinology and Metabolism 264 (6), E855-E862, 1993 | 470 | 1993 |
| Thr2446 is a novel mammalian target of rapamycin (mTOR) phosphorylation site regulated by nutrient status SWY Cheng, LGD Fryer, D Carling, PR Shepherd Journal of Biological Chemistry 279 (16), 15719-15722, 2004 | 417 | 2004 |
| Insulin stimulation of glycogen synthesis and glycogen synthase activity is blocked by wortmannin and rapamycin in 3T3-L1 adipocytes: evidence for the involvement of … PR Shepherd, BT Nave, K Siddle Biochemical Journal 305 (1), 25-28, 1995 | 332 | 1995 |
| Evidence for functional redundancy of class IA PI3K isoforms in insulin signalling C Chaussade, GW Rewcastle, JD Kendall, WA Denny, K Cho, ... Biochemical Journal 404 (3), 449-458, 2007 | 264 | 2007 |
| The role of phosphoinositide 3-kinase C2α in insulin signaling M Falasca, WE Hughes, V Dominguez, G Sala, F Fostira, MQ Fang, ... Journal of Biological Chemistry 282 (38), 28226-28236, 2007 | 209 | 2007 |
| Altered adipocyte properties in the offspring of protein malnourished rats PR Shepherd, NJ Crowther, M Desai, CN Hales, SE Ozanne British Journal of Nutrition 78 (1), 121-129, 1997 | 203 | 1997 |
| Mechanisms regulating phosphoinositide 3‐kinase signalling in insulin‐sensitive tissues PR Shepherd Acta Physiologica Scandinavica 183 (1), 3-12, 2005 | 196 | 2005 |
| Insulin activates the α isoform of class II phosphoinositide 3-kinase RA Brown, J Domin, A Arcaro, MD Waterfield, PR Shepherd Journal of Biological Chemistry 274 (21), 14529-14532, 1999 | 187 | 1999 |
| Poor fetal nutrition causes long-term changes in expression of insulin signaling components in adipocytes SE Ozanne, BT Nave, CL Wang, PR Shepherd, J Prins, GD Smith American Journal of Physiology-Endocrinology And Metabolism 273 (1), E46-E51, 1997 | 183 | 1997 |
| A drug targeting only p110α can block phosphoinositide 3-kinase signalling and tumour growth in certain cell types S Jamieson, JU Flanagan, S Kolekar, C Buchanan, JD Kendall, WJ Lee, ... Biochemical Journal 438 (1), 53-62, 2011 | 180 | 2011 |
| Direct effects of caffeine and theophylline on p110δ and other phosphoinositide 3-kinases: differential effects on lipid kinase and protein kinase activities LC Foukas, N Daniele, C Ktori, KE Anderson, J Jensen, PR Shepherd Journal of Biological Chemistry 277 (40), 37124-37130, 2002 | 179 | 2002 |
| G protein–coupled receptor–mediated activation of p110β by Gβγ is required for cellular transformation and invasiveness HA Dbouk, O Vadas, A Shymanets, JE Burke, RS Salamon, BD Khalil, ... Science signaling 5 (253), ra89-ra89, 2012 | 174 | 2012 |
| Glucose-dependent regulation of cholesterol ester metabolism in macrophages by insulin and leptin L O'Rourke, LM Grønning, SJ Yeaman, PR Shepherd Journal of Biological Chemistry 277 (45), 42557-42562, 2002 | 169 | 2002 |
