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sasaki nobuo
sasaki nobuo
Verified email at gunma-u.ac.jp
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Year
Functional repair of CFTR by CRISPR/Cas9 in intestinal stem cell organoids of cystic fibrosis patients
G Schwank, BK Koo, V Sasselli, JF Dekkers, I Heo, T Demircan, N Sasaki, ...
Cell stem cell 13 (6), 653-658, 2013
16052013
In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration
M Huch, C Dorrell, SF Boj, JH Van Es, VSW Li, M Van De Wetering, ...
Nature 494 (7436), 247-250, 2013
15622013
Long-term culture of genome-stable bipotent stem cells from adult human liver
M Huch, H Gehart, R Van Boxtel, K Hamer, F Blokzijl, MMA Verstegen, ...
Cell 160 (1), 299-312, 2015
14452015
Single-cell messenger RNA sequencing reveals rare intestinal cell types
D Grün, A Lyubimova, L Kester, K Wiebrands, O Basak, N Sasaki, ...
Nature 525 (7568), 251-255, 2015
12572015
Tissue-specific mutation accumulation in human adult stem cells during life
F Blokzijl, J De Ligt, M Jager, V Sasselli, S Roerink, N Sasaki, M Huch, ...
Nature 538 (7624), 260-264, 2016
8822016
Dll1+ secretory progenitor cells revert to stem cells upon crypt damage
JH Van Es, T Sato, M Van De Wetering, A Lyubimova, AN Yee Nee, ...
Nature cell biology 14 (10), 1099-1104, 2012
8182012
Intra-tumour diversification in colorectal cancer at the single-cell level
SF Roerink, N Sasaki, H Lee-Six, MD Young, LB Alexandrov, S Behjati, ...
Nature 556 (7702), 457-462, 2018
4642018
Use of CRISPR-modified human stem cell organoids to study the origin of mutational signatures in cancer
J Drost, R Van Boxtel, F Blokzijl, T Mizutani, N Sasaki, V Sasselli, J de Ligt, ...
Science 358 (6360), 234-238, 2017
4172017
Reg4+ deep crypt secretory cells function as epithelial niche for Lgr5+ stem cells in colon
N Sasaki, N Sachs, K Wiebrands, SIJ Ellenbroek, A Fumagalli, ...
Proceedings of the National Academy of Sciences 113 (37), E5399-E5407, 2016
3302016
Gut pathobionts underlie intestinal barrier dysfunction and liver T helper 17 cell immune response in primary sclerosing cholangitis
N Nakamoto, N Sasaki, R Aoki, K Miyamoto, W Suda, T Teratani, T Suzuki, ...
Nature microbiology 4 (3), 492-503, 2019
3242019
Somatic inflammatory gene mutations in human ulcerative colitis epithelium
K Nanki, M Fujii, M Shimokawa, M Matano, S Nishikori, S Date, A Takano, ...
Nature 577 (7789), 254-259, 2020
2302020
neurotic, a novel maternal neurogenic gene, encodes an O-fucosyltransferase that is essential for Notch-Delta interactions
T Sasamura, N Sasaki, F Miyashita, S Nakao, HO Ishikawa, M Ito, ...
Oxford University Press for The Company of Biologists Limited 130 (20), 4785 …, 2003
1952003
Ongoing chromosomal instability and karyotype evolution in human colorectal cancer organoids
ACF Bolhaqueiro, B Ponsioen, B Bakker, SJ Klaasen, E Kucukkose, ...
Nature genetics 51 (5), 824-834, 2019
1902019
Defining the identity and dynamics of adult gastric isthmus stem cells
S Han, J Fink, DJ Jörg, E Lee, MK Yum, L Chatzeli, SR Merker, ...
Cell stem cell 25 (3), 342-356. e7, 2019
1132019
Automated brightfield morphometry of 3D organoid populations by OrganoSeg
MA Borten, SS Bajikar, N Sasaki, H Clevers, KA Janes
Scientific reports 8 (1), 5319, 2018
1082018
Mutations in the MESP2 gene cause spondylothoracic dysostosis/Jarcho-Levin syndrome
AS Cornier, K Staehling-Hampton, KM Delventhal, Y Saga, JF Caubet, ...
The American Journal of Human Genetics 82 (6), 1334-1341, 2008
1082008
The negative regulation of Mesp2 by mouse Ripply2 is required to establish the rostro-caudal patterning within a somite
M Morimoto, N Sasaki, M Oginuma, M Kiso, K Igarashi, K Aizaki, J Kanno, ...
Oxford University Press for The Company of Biologists Limited 134 (8), 1561-1569, 2007
1082007
The O-fucosyltransferase O-fut1 is an extracellular component that is essential for the constitutive endocytic trafficking of Notch in Drosophila
T Sasamura, HO Ishikawa, N Sasaki, S Higashi, M Kanai, S Nakao, ...
Oxford University Press for The Company of Biologists Limited 134 (7), 1347-1356, 2007
952007
Enteroendocrine and tuft cells support Lgr5 stem cells on Paneth cell depletion
JH van Es, K Wiebrands, C López-Iglesias, M van de Wetering, L Zeinstra, ...
Proceedings of the National Academy of Sciences 116 (52), 26599-26605, 2019
842019
Generation of BAC transgenic epithelial organoids
G Schwank, A Andersson-Rolf, BK Koo, N Sasaki, H Clevers
PloS one 8 (10), e76871, 2013
832013
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