| Control of phosphorothioate stereochemistry substantially increases the efficacy of antisense oligonucleotides N Iwamoto, DCD Butler, N Svrzikapa, S Mohapatra, I Zlatev, DWY Sah, ... Nature biotechnology 35 (9), 845-851, 2017 | 313* | 2017 |
| Influenza A virus-generated small RNAs regulate the switch from transcription to replication JT Perez, A Varble, R Sachidanandam, I Zlatev, M Manoharan, ... Proceedings of the National Academy of Sciences 107 (25), 11525-11530, 2010 | 273 | 2010 |
| Selection of GalNAc-conjugated siRNAs with limited off-target-driven rat hepatotoxicity MM Janas, MK Schlegel, CE Harbison, VO Yilmaz, Y Jiang, R Parmar, ... Nature communications 9 (1), 723, 2018 | 205 | 2018 |
| Investigating the pharmacodynamic durability of GalNAc–siRNA conjugates CR Brown, S Gupta, J Qin, T Racie, G He, S Lentini, R Malone, M Yu, ... Nucleic acids research 48 (21), 11827-11844, 2020 | 160 | 2020 |
| Crystal structure of Middle East respiratory syndrome coronavirus helicase W Hao, JA Wojdyla, R Zhao, R Han, R Das, I Zlatev, M Manoharan, ... PLoS pathogens 13 (6), e1006474, 2017 | 133 | 2017 |
| Expanding RNAi therapeutics to extrahepatic tissues with lipophilic conjugates KM Brown, JK Nair, MM Janas, YI Anglero-Rodriguez, LTH Dang, H Peng, ... Nature biotechnology 40 (10), 1500-1508, 2022 | 95 | 2022 |
| Chiral control D Butler, N Iwamoto, N Svrzikapa, GL Verdine, I ZLATEV US Patent 9,982,257, 2018 | 86 | 2018 |
| A small-RNA enhancer of viral polymerase activity JT Perez, I Zlatev, S Aggarwal, S Subramanian, R Sachidanandam, B Kim, ... Journal of virology 86 (24), 13475-13485, 2012 | 84* | 2012 |
| Strong and sustained antihypertensive effect of small interfering RNA targeting liver angiotensinogen E Uijl, KM Mirabito Colafella, Y Sun, L Ren, R van Veghel, IM Garrelds, ... Hypertension 73 (6), 1249-1257, 2019 | 83 | 2019 |
| Reversal of siRNA-mediated gene silencing in vivo I Zlatev, A Castoreno, CR Brown, J Qin, S Waldron, MK Schlegel, ... Nature biotechnology 36 (6), 509-511, 2018 | 74 | 2018 |
| Chirality dependent potency enhancement and structural impact of glycol nucleic acid modification on siRNA MK Schlegel, DJ Foster, AV Kel’in, I Zlatev, A Bisbe, M Jayaraman, ... Journal of the American Chemical Society 139 (25), 8537-8546, 2017 | 72 | 2017 |
| Efficient solid-phase chemical synthesis of 5′-triphosphates of DNA, RNA, and their analogues I Zlatev, T Lavergne, F Debart, JJ Vasseur, M Manoharan, F Morvan Organic letters 12 (10), 2190-2193, 2010 | 69 | 2010 |
| Safety evaluation of 2′-deoxy-2′-fluoro nucleotides in GalNAc-siRNA conjugates MM Janas, I Zlatev, J Liu, Y Jiang, SA Barros, JE Sutherland, WP Davis, ... Nucleic acids research 47 (7), 3306-3320, 2019 | 63 | 2019 |
| 4′-C-Methoxy-2′-deoxy-2′-fluoro Modified Ribonucleotides Improve Metabolic Stability and Elicit Efficient RNAi-Mediated Gene Silencing E Malek-Adamian, DC Guenther, S Matsuda, S Martínez-Montero, I Zlatev, ... Journal of the American Chemical Society 139 (41), 14542-14555, 2017 | 56 | 2017 |
| A Glu-urea-Lys ligand-conjugated lipid nanoparticle/siRNA system inhibits androgen receptor expression in vivo JB Lee, K Zhang, YYC Tam, J Quick, YK Tam, PJC Lin, S Chen, Y Liu, ... Molecular Therapy-Nucleic Acids 5, 2016 | 43 | 2016 |
| Facile Synthesis, Geometry, and 2′-Substituent-Dependent in Vivo Activity of 5′-(E)- and 5′-(Z)-Vinylphosphonate-Modified siRNA Conjugates RG Parmar, CR Brown, S Matsuda, JLS Willoughby, CS Theile, ... Journal of medicinal chemistry 61 (3), 734-744, 2018 | 40 | 2018 |
| δ-Di-carboxybutyl phosphoramidate of 2′-deoxycytidine-5′-monophosphate as substrate for DNA polymerization by HIV-1 reverse transcriptase I Zlatev, A Giraut, F Morvan, P Herdewijn, JJ Vasseur Bioorganic & medicinal chemistry 17 (19), 7008-7014, 2009 | 38 | 2009 |
| The nonclinical disposition and pharmacokinetic/pharmacodynamic properties of N-Acetylgalactosamine–conjugated small interfering RNA are highly predictable and build confidence … R McDougall, D Ramsden, S Agarwal, S Agarwal, K Aluri, M Arciprete, ... Drug Metabolism and Disposition 50 (6), 781-797, 2022 | 36 | 2022 |
| Solid‐Phase Chemical Synthesis of 5′‐Triphosphate DNA, RNA, and Chemically Modified Oligonucleotides I Zlatev, M Manoharan, JJ Vasseur, F Morvan Current protocols in nucleic acid chemistry 50 (1), 1.28. 1-1.28. 16, 2012 | 34 | 2012 |
| Structural Basis of Duplex Thermodynamic Stability and Enhanced Nuclease Resistance of 5′-C-Methyl Pyrimidine-Modified Oligonucleotides AV Kel′ in, I Zlatev, J Harp, M Jayaraman, A Bisbe, J O′ Shea, ... The Journal of organic chemistry 81 (6), 2261-2279, 2016 | 33 | 2016 |
Nenad SvrzikapaUniversity of Oxford, Harvard University, Wave Life SciencesGeverifieerd e-mailadres voor g.harvard.edu
