|The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5|
KMA Rouschop, T Van Den Beucken, L Dubois, H Niessen, J Bussink, ...
The Journal of clinical investigation 120 (1), 127-141, 2010
|Disparity between in vivo EGFR expression and 89Zr-labeled cetuximab uptake assessed with PET|
HJWL Aerts, L Dubois, L Perk, P Vermaelen, GAMS van Dongen, ...
Journal of Nuclear Medicine 50 (1), 123-131, 2009
|Imaging of CA IX with fluorescent labelled sulfonamides distinguishes hypoxic and (re)-oxygenated cells in a xenograft tumour model|
L Dubois, NG Lieuwes, A Maresca, A Thiry, CT Supuran, A Scozzafava, ...
Radiotherapy and Oncology 92 (3), 423-428, 2009
|Taking advantage of tumor cell adaptations to hypoxia for developing new tumor markers and treatment strategies|
P Ebbesen, EO Pettersen, TA Gorr, G Jobst, K Williams, J Kieninger, ...
Journal of enzyme inhibition and medicinal chemistry 24 (sup1), 1-39, 2009
|Specific inhibition of carbonic anhydrase IX activity enhances the in vivo therapeutic effect of tumor irradiation|
L Dubois, S Peeters, NG Lieuwes, N Geusens, A Thiry, S Wigfield, F Carta, ...
Radiotherapy and Oncology 99 (3), 424-431, 2011
|Imaging the hypoxia surrogate marker CA IX requires expression and catalytic activity for binding fluorescent sulfonamide inhibitors|
L Dubois, K Douma, CT Supuran, RK Chiu, MAMJ van Zandvoort, ...
Radiotherapy and oncology 83 (3), 367-373, 2007
|PERK/eIF2α signaling protects therapy resistant hypoxic cells through induction of glutathione synthesis and protection against ROS|
KM Rouschop, LJ Dubois, TG Keulers, T van den Beucken, P Lambin, ...
Proceedings of the National Academy of Sciences 110 (12), 4622-4627, 2013
|How do changes in the mtDNA and mitochondrial dysfunction influence cancer and cancer therapy? Challenges, opportunities and models|
MW Van Gisbergen, AM Voets, MHW Starmans, IFM De Coo, R Yadak, ...
Mutation Research/Reviews in Mutation Research 764, 16-30, 2015
|Repeated cycles of Clostridium-directed enzyme prodrug therapy result in sustained antitumour effects in vivo|
J Theys, O Pennington, L Dubois, G Anlezark, T Vaughan, A Mengesha, ...
British journal of cancer 95 (9), 1212-1219, 2006
|Evaluation of hypoxia in an experimental rat tumour model by [18 F] fluoromisonidazole PET and immunohistochemistry|
L Dubois, W Landuyt, K Haustermans, P Dupont, G Bormans, ...
British journal of cancer 91 (11), 1947-1954, 2004
|A comparative study of the hypoxia PET tracers [18F] HX4,[18F] FAZA, and [18F] FMISO in a preclinical tumor model|
SGJA Peeters, CML Zegers, NG Lieuwes, W van Elmpt, J Eriksson, ...
International Journal of Radiation Oncology* Biology* Physics 91 (2), 351-359, 2015
|Preclinical evaluation and validation of [18F] HX4, a promising hypoxia marker for PET imaging|
LJ Dubois, NG Lieuwes, MHM Janssen, WJM Peeters, AD Windhorst, ...
Proceedings of the National Academy of Sciences 108 (35), 14620-14625, 2011
|PET imaging of hypoxia using [18F]HX4: a phase I trial|
J van Loon, MHM Janssen, M Íllers, HJWL Aerts, L Dubois, ...
European journal of nuclear medicine and molecular imaging 37 (9), 1663-1668, 2010
|Synthesis and biological evaluation of a 99mTc-labelled sulfonamide conjugate for in vivo visualization of carbonic anhydrase IX expression in tumor hypoxia|
V Akurathi, L Dubois, NG Lieuwes, SK Chitneni, BJ Cleynhens, D Vullo, ...
Nuclear medicine and biology 37 (5), 557-564, 2010
|Decision support systems for personalized and participative radiation oncology|
P Lambin, J Zindler, BGL Vanneste, L Van De Voorde, D Eekers, ...
Advanced drug delivery reviews 109, 131-153, 2017
|Targeting tumour hypoxia to prevent cancer metastasis. From biology, biosensing and technology to drug development: the METOXIA consortium|
EO Pettersen, P Ebbesen, RG Gieling, KJ Williams, L Dubois, P Lambin, ...
Journal of enzyme inhibition and medicinal chemistry 30 (5), 689-721, 2015
|Is there a causal relationship between genetic changes and radiomics-based image features? An in vivo preclinical experiment with doxycycline inducible GADD34 tumor cells|
KM Panth, RTH Leijenaar, S Carvalho, NG Lieuwes, A Yaromina, ...
Radiotherapy and Oncology 116 (3), 462-466, 2015
|TH-302 in combination with radiotherapy enhances the therapeutic outcome and is associated with pretreatment [18F] HX4 hypoxia PET imaging|
SGJA Peeters, CML Zegers, R Biemans, NG Lieuwes, ...
Clinical Cancer Research 21 (13), 2984-2992, 2015
|Prognostic significance of carbonic anhydrase IX expression in cancer patients: a meta-analysis|
SJA van Kuijk, A Yaromina, R Houben, R Niemans, P Lambin, LJ Dubois
Frontiers in oncology 6, 69, 2016
|Targeting carbonic anhydrase IX by nitroimidazole based sulfamides enhances the therapeutic effect of tumor irradiation: a new concept of dual targeting drugs|
L Dubois, SGJA Peeters, SJA van Kuijk, A Yaromina, NG Lieuwes, ...
Radiotherapy and Oncology 108 (3), 523-528, 2013