Richard Siegel
Richard Siegel
Novartis Institutes of BioMedical Research
Verified email at - Homepage
Cited by
Cited by
Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation
A Laurence, CM Tato, TS Davidson, Y Kanno, Z Chen, Z Yao, RB Blank, ...
Immunity 26 (3), 371-381, 2007
A domain in TNF receptors that mediates ligand-independent receptor assembly and signaling
FKM Chan, HJ Chun, L Zheng, RM Siegel, KL Bui, MJ Lenardo
Science 288 (5475), 2351-2354, 2000
Mature T lymphocyte apoptosis—immune regulation in a dynamic and unpredictable antigenic environment
M Lenardo, FKM Chan, F Hornung, H McFarland, R Siegel, J Wang, ...
Annual review of immunology 17 (1), 221-253, 1999
Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS)
AC Bulua, A Simon, R Maddipati, M Pelletier, H Park, KY Kim, MN Sack, ...
Journal of Experimental Medicine 208 (3), 519-533, 2011
FinnGen provides genetic insights from a well-phenotyped isolated population
MI Kurki, J Karjalainen, P Palta, TP Sipilš, K Kristiansson, KM Donner, ...
Nature 613 (7944), 508-518, 2023
Fas preassociation required for apoptosis signaling and dominant inhibition by pathogenic mutations
RM Siegel, JK Frederiksen, DA Zacharias, FKM Chan, M Johnson, ...
Science 288 (5475), 2354-2357, 2000
Pleiotropic defects in lymphocyte activation caused by caspase-8 mutations lead to human immunodeficiency
HJ Chun, L Zheng, M Ahmad, J Wang, CK Speirs, RM Siegel, JK Dale, ...
Nature 419 (6905), 395-399, 2002
The multifaceted role of Fas signaling in immune cell homeostasis and autoimmunity
RM Siegel, F Ka-Ming Chan, HJ Chun, MJ Lenardo
Nature immunology 1 (6), 469-474, 2000
Loss-of-function mutations in TNFAIP3 leading to A20 haploinsufficiency cause an early-onset autoinflammatory disease
Q Zhou, H Wang, DM Schwartz, M Stoffels, YH Park, Y Zhang, D Yang, ...
Nature genetics 48 (1), 67-73, 2016
Membrane oligomerization and cleavage activates the caspase-8 (FLICE/MACHα1) death signal
DA Martin, RM Siegel, L Zheng, MJ Lenardo
Journal of Biological Chemistry 273 (8), 4345-4349, 1998
Revised diagnostic criteria and classification for the autoimmune lymphoproliferative syndrome (ALPS): report from the 2009 NIH International Workshop
JB Oliveira, JJ Bleesing, U Dianzani, TA Fleisher, ES Jaffe, MJ Lenardo, ...
Blood, The Journal of the American Society of Hematology 116 (14), e35-e40, 2010
Genome-Wide Association Study in Asian Populations Identifies Variants in ETS1 and WDFY4 Associated with Systemic Lupus Erythematosus
W Yang, N Shen, DQ Ye, Q Liu, Y Zhang, XX Qian, N Hirankarn, D Ying, ...
PLoS genetics 6 (2), e1000841, 2010
Selective recognition of acetylated histones by bromodomain proteins visualized in living cells
T Kanno, Y Kanno, RM Siegel, MK Jang, MJ Lenardo, K Ozato
Molecular cell 13 (1), 33-43, 2004
TNF receptor 1 genetic risk mirrors outcome of anti-TNF therapy in multiple sclerosis
AP Gregory, CA Dendrou, KE Attfield, A Haghikia, DK Xifara, F Butter, ...
Nature 488 (7412), 508-511, 2012
IL-21 drives expansion and plasma cell differentiation of autoreactive CD11chiT-bet+ B cells in SLE
S Wang, J Wang, V Kumar, JL Karnell, B Naiman, PS Gross, S Rahman, ...
Nature communications 9 (1), 1758, 2018
Life and death decisions: secondary complexes and lipid rafts in TNF receptor family signal transduction
JR Muppidi, J Tschopp, RM Siegel
Immunity 21 (4), 461-465, 2004
Caspases at the crossroads of immune-cell life and death
RM Siegel
Nature Reviews Immunology 6 (4), 308-317, 2006
FinnGen: Unique genetic insights from combining isolated population and national health register data
MI Kurki, J Karjalainen, P Palta, TP Sipilš, K Kristiansson, K Donner, ...
MedRxiv, 2022.03. 03.22271360, 2022
The Fas–FADD death domain complex structure reveals the basis of DISC assembly and disease mutations
L Wang, JK Yang, V Kabaleeswaran, AJ Rice, AC Cruz, AY Park, Q Yin, ...
Nature structural & molecular biology 17 (11), 1324-1329, 2010
Death-effector filaments: novel cytoplasmic structures that recruit caspases and trigger apoptosis
RM Siegel, DA Martin, L Zheng, SY Ng, J Bertin, J Cohen, MJ Lenardo
The Journal of cell biology 141 (5), 1243-1253, 1998
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