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Marianne G Rots
Marianne G Rots
hoogleraar Moleculaire Epigenetica
Geverifieerd e-mailadres voor umcg.nl
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EpCAM in carcinogenesis: the good, the bad or the ugly
BTF van der Gun, LJ Melchers, MHJ Ruiters, LFMH de Leij, ...
Carcinogenesis 31 (11), 1913-1921, 2010
3982010
Genome analyses of> 200,000 individuals identify 58 loci for chronic inflammation and highlight pathways that link inflammation and complex disorders
S Ligthart, A Vaez, U Vősa, MG Stathopoulou, PS De Vries, BP Prins, ...
The American Journal of Human Genetics 103 (5), 691-706, 2018
3522018
Epigenetic reprogramming of cancer cells via targeted DNA methylation
AG Rivenbark, S Stolzenburg, AS Beltran, X Yuan, MG Rots, BD Strahl, ...
Epigenetics 7 (4), 350-360, 2012
3302012
Expression of deoxycytidine kinase in leukaemic cells compared with solid tumour cell lines, liver metastases and normal liver
CL Van Der Wilt, JR Kroep, WJP Loves, MG Rots, CJ Van Groeningen, ...
European Journal of Cancer 39 (5), 691-697, 2003
3082003
Genetic evidence of assortative mating in humans
MR Robinson, A Kleinman, M Graff, AAE Vinkhuyzen, D Couper, ...
Nature Human Behaviour 1 (1), 0016, 2017
2922017
The timeline of epigenetic drug discovery: from reality to dreams
A Ganesan, PB Arimondo, MG Rots, C Jeronimo, M Berdasco
Clinical epigenetics 11, 1-17, 2019
2882019
Writing of H3K4Me3 overcomes epigenetic silencing in a sustained but context-dependent manner
D Cano-Rodriguez, RAF Gjaltema, LJ Jilderda, P Jellema, ...
Nature communications 7 (1), 12284, 2016
2672016
Epigenetic Editing : targeted rewriting of epigenetic marks to modulate expression of selected target genes
ML de Groote, PJ Verschure, MG Rots
Nucleic acids research 40 (21), 10596-10613, 2012
2132012
Differential effects of NF-κB and p38 MAPK inhibitors and combinations thereof on TNF-α-and IL-1β-induced proinflammatory status of endothelial cells in vitro
JM Kułdo, J Westra, SA Asgeirsdóttir, RJ Kok, K Oosterhuis, MG Rots, ...
American Journal of Physiology-Cell Physiology 289 (5), C1229-C1239, 2005
2022005
Different drug sensitivity profiles of acute myeloid and lymphoblastic leukemia and normal peripheral blood mononuclear cells in children with and without Down syndrome
CM Zwaan, GJL Kaspers, R Pieters, K Hählen, GE Janka-Schaub, ...
Blood, The Journal of the American Society of Hematology 99 (1), 245-251, 2002
1962002
Targeted silencing of the oncogenic transcription factor SOX2 in breast cancer
S Stolzenburg, MG Rots, AS Beltran, AG Rivenbark, X Yuan, H Qian, ...
Nucleic acids research 40 (14), 6725-6740, 2012
1912012
Targeted methylation and gene silencing of VEGF-A in human cells by using a designed Dnmt3a–Dnmt3L single-chain fusion protein with increased DNA methylation activity
AN Siddique, S Nunna, A Rajavelu, Y Zhang, RZ Jurkowska, R Reinhardt, ...
Journal of molecular biology 425 (3), 479-491, 2013
1902013
Induced DNA demethylation by targeting Ten-Eleven Translocation 2 to the human ICAM-1 promoter
H Chen, HG Kazemier, ML de Groote, MHJ Ruiters, GL Xu, MG Rots
Nucleic acids research 42 (3), 1563-1574, 2014
1842014
Role of folylpolyglutamate synthetase and folylpolyglutamate hydrolase in methotrexate accumulation and polyglutamylation in childhood leukemia
MG Rots, R Pieters, GJ Peters, P Noordhuis, CH Van Zantwijk, ...
Blood, The Journal of the American Society of Hematology 93 (5), 1677-1683, 1999
1781999
A Novel Strategy to Modify Adenovirus Tropism and Enhance Transgene Delivery to Activated Vascular Endothelial Cells In Vitro and In Vivo
K Ogawara, MG Rots, RJ Kok, HE Moorlag, AM Van Loenen, DKF Meijer, ...
Human gene therapy 15 (5), 433-443, 2004
1762004
Epigenetic editing of the Dlg4/PSD95 gene improves cognition in aged and Alzheimer’s disease mice
FJ Bustos, E Ampuero, N Jury, R Aguilar, F Falahi, J Toledo, J Ahumada, ...
Brain 140 (12), 3252-3268, 2017
1422017
The influence of eukaryotic chromatin state on CRISPR–Cas9 editing efficiencies
SAN Verkuijl, MG Rots
Current opinion in biotechnology 55, 68-73, 2019
1242019
Therapeutic modulation of endogenous gene function by agents with designed DNA‐sequence specificities
TG Uil, HJ Haisma, MG Rots
Nucleic acids research 31 (21), 6064-6078, 2003
1222003
Local chromatin microenvironment determines DNMT activity: from DNA methyltransferase to DNA demethylase or DNA dehydroxymethylase
MGP van der Wijst, M Venkiteswaran, H Chen, GL Xu, T Plösch, MG Rots
Epigenetics 10 (8), 671-676, 2015
1032015
Experimental mitochondria-targeted DNA methylation identifies GpC methylation, not CpG methylation, as potential regulator of mitochondrial gene expression
MGP van der Wijst, AY van Tilburg, MHJ Ruiters, MG Rots
Scientific reports 7 (1), 177, 2017
1022017
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Artikelen 1–20