Patrick Scheerer
Patrick Scheerer
Research Group Leader - Charité - Universitätsmedizin Berlin - Institute of Medical Physics
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Crystal structure of opsin in its G-protein-interacting conformation
P Scheerer, JH Park, PW Hildebrand, YJ Kim, N Krauß, HW Choe, ...
Nature 455 (7212), 497-502, 2008
Crystal structure of the ligand-free G-protein-coupled receptor opsin
JH Park, P Scheerer, KP Hofmann, HW Choe, OP Ernst
Nature 454 (7201), 183-187, 2008
Crystal structure of metarhodopsin II
HW Choe, YJ Kim, JH Park, T Morizumi, EF Pai, N Krauss, KP Hofmann, ...
Nature 471 (7340), 651-655, 2011
AG protein-coupled receptor at work: the rhodopsin model
KP Hofmann, P Scheerer, PW Hildebrand, HW Choe, JH Park, M Heck, ...
Trends in biochemical sciences 34 (11), 540-552, 2009
The crystal structure of an oxygen-tolerant hydrogenase uncovers a novel iron-sulphur centre
J Fritsch, P Scheerer, S Frielingsdorf, S Kroschinsky, B Friedrich, O Lenz, ...
Nature 479 (7372), 249-252, 2011
Crystal structure of a common GPCR-binding interface for G protein and arrestin
M Szczepek, F Beyrière, KP Hofmann, M Elgeti, R Kazmin, A Rose, ...
Nature communications 5 (1), 1-8, 2014
Crystal structure of pre-activated arrestin p44
YJ Kim, KP Hofmann, OP Ernst, P Scheerer, HW Choe, ME Sommer
Nature 497 (7447), 142-146, 2013
Structural Basis for Catalytic Activity and Enzyme Polymerization of Phospholipid Hydroperoxide Glutathione Peroxidase-4 (GPx4),,
P Scheerer, A Borchert, N Krauss, H Wessner, C Gerth, W Höhne, H Kuhn
Biochemistry 46 (31), 9041-9049, 2007
Structural snapshots of actively translating human ribosomes
E Behrmann, J Loerke, TV Budkevich, K Yamamoto, A Schmidt, ...
Cell 161 (4), 845-857, 2015
Highly conserved residues Asp-197 and His-250 in Agp1 phytochrome control the proton affinity of the chromophore and Pfr formation
D von Stetten, S Seibeck, N Michael, P Scheerer, MA Mroginski, ...
Journal of Biological Chemistry 282 (3), 2116-2123, 2007
MC4R agonism promotes durable weight loss in patients with leptin receptor deficiency
K Clément, H Biebermann, IS Farooqi, L Van der Ploeg, B Wolters, ...
Nature medicine 24 (5), 551-555, 2018
A ligand channel through the G protein coupled receptor opsin
PW Hildebrand, P Scheerer, JH Park, HW Choe, R Piechnick, OP Ernst, ...
PloS one 4 (2), e4382, 2009
Reversible [4Fe-3S] cluster morphing in an O 2-tolerant [NiFe] hydrogenase
S Frielingsdorf, J Fritsch, A Schmidt, M Hammer, J Löwenstein, E Siebert, ...
Nature chemical biology 10 (5), 378-385, 2014
Double-flow focused liquid injector for efficient serial femtosecond crystallography
D Oberthuer, J Knoška, MO Wiedorn, KR Beyerlein, DA Bushnell, ...
Scientific reports 7 (1), 1-12, 2017
Position of transmembrane helix 6 determines receptor G protein coupling specificity
AS Rose, M Elgeti, U Zachariae, H Grubmüller, KP Hofmann, ...
Journal of the American Chemical Society 136 (32), 11244-11247, 2014
Crystal structure of a prokaryotic (6-4) photolyase with an Fe-S cluster and a 6, 7-dimethyl-8-ribityllumazine antenna chromophore
F Zhang, P Scheerer, I Oberpichler, T Lamparter, N Krauß
Proceedings of the National Academy of Sciences 110 (18), 7217-7222, 2013
Chromophore heterogeneity and photoconversion in phytochrome crystals and solution studied by resonance Raman spectroscopy
D Von Stetten, M Günther, P Scheerer, DH Murgida, MA Mroginski, ...
Angewandte Chemie International Edition 47 (25), 4753-4755, 2008
The complex of tmRNA–SmpB and EF-G on translocating ribosomes
DJF Ramrath, H Yamamoto, K Rother, D Wittek, M Pech, T Mielke, ...
Nature 485 (7399), 526-529, 2012
Effect of channel mutations on the uptake and release of the retinal ligand in opsin
R Piechnick, E Ritter, PW Hildebrand, OP Ernst, P Scheerer, KP Hofmann, ...
Proceedings of the National Academy of Sciences 109 (14), 5247-5252, 2012
Structural basis for two-component system inhibition and pilus sensing by the auxiliary CpxP protein
X Zhou, R Keller, R Volkmer, N Krauss, P Scheerer, S Hunke
Journal of Biological Chemistry 286 (11), 9805-9814, 2011
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