Primary human lung alveolus‐on‐a‐chip model of intravascular thrombosis for assessment of therapeutics A Jain, R Barrile, AD van der Meer, A Mammoto, T Mammoto, ... Clinical pharmacology & therapeutics 103 (2), 332-340, 2018 | 283 | 2018 |
Parmodulins inhibit thrombus formation without inducing endothelial injury caused by vorapaxar O Aisiku, CG Peters, K De Ceunynck, CC Ghosh, JR Dilks, ... Blood, The Journal of the American Society of Hematology 125 (12), 1976-1985, 2015 | 95 | 2015 |
PAR1 agonists stimulate APC-like endothelial cytoprotection and confer resistance to thromboinflammatory injury K De Ceunynck, CG Peters, A Jain, SJ Higgins, O Aisiku, JL Fitch-Tewfik, ... Proceedings of the National Academy of Sciences 115 (5), E982-E991, 2018 | 72 | 2018 |
VAMP-7 links granule exocytosis to actin reorganization during platelet activation S Koseoglu, CG Peters, JL Fitch-Tewfik, O Aisiku, L Danglot, T Galli, ... Blood, The Journal of the American Society of Hematology 126 (5), 651-660, 2015 | 71 | 2015 |
Discovery of 1, 3-diaminobenzenes as selective inhibitors of platelet activation at the PAR1 receptor C Dockendorff, O Aisiku, L VerPlank, JR Dilks, DA Smith, SF Gunnink, ... ACS Medicinal Chemistry Letters 3 (3), 232-237, 2012 | 59 | 2012 |
Identification of a novel binding partner of phospholipase Cβ1: translin-associated factor X OR Aisiku, LW Runnels, S Scarlata PloS one 5 (11), e15001, 2010 | 56 | 2010 |
Protein kinase C phosphorylation of PLCβ1 regulates its cellular localization O Aisiku, L Dowal, S Scarlata Archives of biochemistry and biophysics 509 (2), 186-190, 2011 | 34 | 2011 |
Complement activation in trauma patients alters platelet function G Atefi, O Aisiku, N Shapiro, C Hauser, J Dalle Lucca, R Flaumenhaft, ... Shock 46 (3S), 83-88, 2016 | 33 | 2016 |
A chemical APC mimetic protects endothelium from thromboinflammatory injury KEP De Ceunynck, CG Peters, SA Chaudhry, A Jain, SJ Higgins, O Aisiku, ... Blood 128 (22), 3835, 2016 | 4 | 2016 |
Reverse Translation A Jain, R Barrile, A van der Meer, A Mammoto, T Mammoto, K Ceunynck, ... CLINICAL PHARMACOLOGY AND THERAPEUTICS-ST LOUIS- 103 (2), 332-340, 2018 | | 2018 |
Analysis of Mechanism of a Novel Drug Candidate using an Organ-level Functional Microdevice that Reconstitutes Human Pulmonary Thrombosis A Jain, R Barrile, O Aisiku, KD Ceunynck, AD van der Meer, MA Otieno, ... Arteriosclerosis, Thrombosis, and Vascular Biology 36 (suppl_1), A342-A342, 2016 | | 2016 |
VAMP-7 links granule exocytosis to platelet spreading S Koseoglu, JL Fitch-Tewfik, CG Peters, O Aisiku, L Danglot, T Galli, ... JOURNAL OF THROMBOSIS AND HAEMOSTASIS 13, 61-61, 2015 | | 2015 |
A class of biased PAR1 agonists that stimulate cytoprotective signaling in endothelial cells OR Aisiku, CG Peters, KD Ceunyck, J Fitch-Tewfik, JR Dilks, ... JOURNAL OF THROMBOSIS AND HAEMOSTASIS 13, 33-33, 2015 | | 2015 |
Effects Of Biased PAR1 Ligands On Platelets and Endothelial Cells OR Aisiku, CG Peters, S Gunnink, JR Dilks, C Dockendorff, R Flaumenhaft Blood 122 (21), 23, 2013 | | 2013 |
Parmodulins act at PAR1 to stimulate cytoprotective genetic program in endothelial cells OR Aisiku, CG Peters, JR Dilks, JL Fitch-Tewfik, C Dockendorff, ... JOURNAL OF THROMBOSIS AND HAEMOSTASIS 11, 202-203, 2013 | | 2013 |
Parmodulins target the intracellular side of PAR1 to selectively interfere with Gaq but not Ga12/13 signaling and block thrombus formation, but not hemostasis OR Aisiku, CG Peters, JR Dilks, S Gunnink, C Dockendorff, DA Smith, ... JOURNAL OF THROMBOSIS AND HAEMOSTASIS 11, 106-107, 2013 | | 2013 |
Acyl-Protein Thioesterase 1 Functions in Palmitoylation/Depalmitoylation Cycles of G Proteins and Regulates Platelet Activation LM Dowal, JR Dilks, NA Fadel, OR Aisiku, G Merrill-Skoloff, ... Blood, The Journal of the American Society of Hematology 120 (21), 1062-1062, 2012 | | 2012 |
An Allosteric Modulator of PAR1 Demonstrates Selective Inhibition of G Protein Coupling and Impairs Thrombus Formation In Vivo OR Aisiku, C Dockendorff, SF Gunnick, DA Smith, JR Dilks, LM Dowal, ... Blood 118 (21), 1138, 2011 | | 2011 |
The Identification of a Novel Binding Partner for Phospholipase Cβ1, Translin-Associated Factor X: A Link to RNA Interference OR Aisiku State University of New York at Stony Brook, 2010 | | 2010 |