Kullervo Hynynen
Kullervo Hynynen
Professor of Medical Biophysics, University of Toronto
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Cited by
Cited by
Noninvasive MR imaging–guided focal opening of the blood-brain barrier in rabbits
K Hynynen, N McDannold, N Vykhodtseva, FA Jolesz
Radiology 220 (3), 640-646, 2001
A randomized trial of focused ultrasound thalamotomy for essential tremor
WJ Elias, N Lipsman, WG Ondo, P Ghanouni, YG Kim, W Lee, M Schwartz, ...
New England Journal of Medicine 375 (8), 730-739, 2016
Apparatus and method for intra-cardiac ablation of arrhythmias
FI Marcus, KH Hynynen
US Patent 5,295,484, 1994
MR imaging-guided focused ultrasound surgery of fibroadenomas in the breast: a feasibility study
K Hynynen, O Pomeroy, DN Smith, PE Huber, NJ McDannold, ...
Radiology 219 (1), 176-185, 2001
MR imaging–guided focused ultrasound surgery of uterine leiomyomas: a feasibility study
CMC Tempany, EA Stewart, N McDannold, BJ Quade, FA Jolesz, ...
Radiology 226 (3), 897-905, 2003
Blood–brain barrier opening in Alzheimer’s disease using MR-guided focused ultrasound
N Lipsman, Y Meng, AJ Bethune, Y Huang, B Lam, M Masellis, ...
Nature communications 9 (1), 2336, 2018
Overview of therapeutic ultrasound applications and safety considerations
DL Miller, NB Smith, MR Bailey, GJ Czarnota, K Hynynen, IRS Makin, ...
Journal of ultrasound in medicine 31 (4), 623-634, 2012
Local and reversible blood–brain barrier disruption by noninvasive focused ultrasound at frequencies suitable for trans-skull sonications
K Hynynen, N McDannold, NA Sheikov, FA Jolesz, N Vykhodtseva
Neuroimage 24 (1), 12-20, 2005
Noninvasive localized delivery of Herceptin to the mouse brain by MRI-guided focused ultrasound-induced blood–brain barrier disruption
M Kinoshita, N McDannold, FA Jolesz, K Hynynen
Proceedings of the National Academy of Sciences 103 (31), 11719-11723, 2006
Cellular mechanisms of the blood-brain barrier opening induced by ultrasound in presence of microbubbles
N Sheikov, N McDannold, N Vykhodtseva, F Jolesz, K Hynynen
Ultrasound in medicine & biology 30 (7), 979-989, 2004
Transcranial magnetic resonance imaging–guided focused ultrasound surgery of brain tumors: initial findings in 3 patients
N McDannold, GT Clement, P Black, F Jolesz, K Hynynen
Neurosurgery 66 (2), 323-332, 2010
MR-guided focused ultrasound thalamotomy for essential tremor: a proof-of-concept study
N Lipsman, ML Schwartz, Y Huang, L Lee, T Sankar, M Chapman, ...
The Lancet Neurology 12 (5), 462-468, 2013
Targeted delivery of doxorubicin to the rat brain at therapeutic levels using MRI‐guided focused ultrasound
LH Treat, N McDannold, N Vykhodtseva, Y Zhang, K Tam, K Hynynen
International journal of cancer 121 (4), 901-907, 2007
A non-invasive method for focusing ultrasound through the human skull
GT Clement, K Hynynen
Physics in medicine & biology 47 (8), 1219, 2002
Effect of focused ultrasound applied with an ultrasound contrast agent on the tight junctional integrity of the brain microvascular endothelium
N Sheikov, N McDannold, S Sharma, K Hynynen
Ultrasound in medicine & biology 34 (7), 1093-1104, 2008
Demonstration of potential noninvasive ultrasound brain therapy through an intact skull
K Hynynen, FA Jolesz
Ultrasound in medicine & biology 24 (2), 275-283, 1998
Targeted disruption of the blood–brain barrier with focused ultrasound: association with cavitation activity
N McDannold, N Vykhodtseva, K Hynynen
Physics in Medicine & Biology 51 (4), 793, 2006
The threshold for thermally significant cavitation in dog's thigh muscle in vivo
K Hynynen
Ultrasound in medicine & biology 17 (2), 157-169, 1991
Blood-brain barrier opening in primary brain tumors with non-invasive MR-guided focused ultrasound: a clinical safety and feasibility study
T Mainprize, N Lipsman, Y Huang, Y Meng, A Bethune, S Ironside, ...
Scientific reports 9 (1), 321, 2019
Chemotherapy delivery issues in central nervous system malignancy: a reality check
LL Muldoon, C Soussain, K Jahnke, C Johanson, T Siegal, QR Smith, ...
Journal of clinical oncology 25 (16), 2295-2305, 2007
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