| Optknock: a bilevel programming framework for identifying gene knockout strategies for microbial strain optimization AP Burgard, P Pharkya, CD Maranas Biotechnology and bioengineering 84 (6), 647-657, 2003 | 1525 | 2003 |
| Metabolic engineering of Escherichia coli for direct production of 1,4-butanediol H Yim, R Haselbeck, W Niu, C Pujol-Baxley, A Burgard, J Boldt, ... Nature chemical biology 7 (7), 445-452, 2011 | 1313 | 2011 |
| OptStrain: a computational framework for redesign of microbial production systems P Pharkya, AP Burgard, CD Maranas Genome research 14 (11), 2367-2376, 2004 | 613 | 2004 |
| Flux coupling analysis of genome-scale metabolic network reconstructions AP Burgard, EV Nikolaev, CH Schilling, CD Maranas Genome research 14 (2), 301-312, 2004 | 516 | 2004 |
| In silico design and adaptive evolution of Escherichia coli for production of lactic acid SS Fong, AP Burgard, CD Herring, EM Knight, FR Blattner, CD Maranas, ... Biotechnology and bioengineering 91 (5), 643-648, 2005 | 489 | 2005 |
| Optimization‐based framework for inferring and testing hypothesized metabolic objective functions AP Burgard, CD Maranas Biotechnology and bioengineering 82 (6), 670-677, 2003 | 298 | 2003 |
| Development of a commercial scale process for production of 1, 4-butanediol from sugar A Burgard, MJ Burk, R Osterhout, S Van Dien, H Yim Current opinion in biotechnology 42, 118-125, 2016 | 290 | 2016 |
| Minimal Reaction Sets for Escherichia coli Metabolism under Different Growth Requirements and Uptake Environments AP Burgard, S Vaidyaraman, CD Maranas Biotechnology progress 17 (5), 791-797, 2001 | 212 | 2001 |
| Methods and organisms for the growth-coupled production of 1, 4-butanediol AP Burgard, SJ Van Dien, M Burk US Patent 7,947,483, 2011 | 197 | 2011 |
| Exploring the overproduction of amino acids using the bilevel optimization framework OptKnock P Pharkya, AP Burgard, CD Maranas Biotechnology and bioengineering 84 (7), 887-899, 2003 | 190 | 2003 |
| Method and system for modeling cellular metabolism CD Maranas, AP Burgard US Patent 7,711,490, 2010 | 187 | 2010 |
| Method for determining gene knockouts CD Maranas, AR Burgard, P Pharkya US Patent 8,027,821, 2011 | 182 | 2011 |
| Probing the performance limits of the Escherichia coli metabolic network subject to gene additions or deletions AP Burgard, CD Maranas Biotechnology and bioengineering 74 (5), 364-375, 2001 | 170 | 2001 |
| Predicting biological system objectives de novo from internal state measurements EP Gianchandani, MA Oberhardt, AP Burgard, CD Maranas, JA Papin BMC bioinformatics 9, 1-13, 2008 | 142 | 2008 |
| Geobacter sulfurreducens strain engineered for increased rates of respiration M Izallalen, R Mahadevan, A Burgard, B Postier, R Didonato Jr, J Sun, ... Metabolic engineering 10 (5), 267-275, 2008 | 140 | 2008 |
| Compositions and methods for the biosynthesis of 1, 4-butanediol and its precursors MJ Burk, SJ Van Dien, AP Burgard, W Niu US Patent 8,067,214, 2011 | 138 | 2011 |
| Metabolic flux elucidation for large-scale models using 13C labeled isotopes PF Suthers, AP Burgard, MS Dasika, F Nowroozi, S Van Dien, ... Metabolic engineering 9 (5-6), 387-405, 2007 | 129 | 2007 |
| Microorganisms for the production of adipic acid and other compounds AP Burgard, P Pharkya, RE Osterhout US Patent 7,799,545, 2010 | 127 | 2010 |
| Microorganisms and methods for the biosynthesis of butadiene MJ Burk, AP Burgard, J Sun, RE Osterhout, P Pharkya US Patent 8,580,543, 2013 | 108* | 2013 |
| Methods and organisms for the growth-coupled production of succinate A Burgard, S Van Dien US Patent App. 11/518,502, 2007 | 106 | 2007 |
