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Isaac Hilton
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Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from promoters and enhancers
IB Hilton, AM D'ippolito, CM Vockley, PI Thakore, GE Crawford, TE Reddy, ...
Nature biotechnology 33 (5), 510-517, 2015
20222015
Editing the epigenome: technologies for programmable transcription and epigenetic modulation
PI Thakore, JB Black, IB Hilton, CA Gersbach
Nature methods 13 (2), 127-137, 2016
4572016
CRISPR–Cas9 epigenome editing enables high-throughput screening for functional regulatory elements in the human genome
TS Klann, JB Black, M Chellappan, A Safi, L Song, IB Hilton, GE Crawford, ...
Nature biotechnology 35 (6), 561-568, 2017
4442017
Multiplex CRISPR/Cas9-based genome engineering from a single lentiviral vector
AM Kabadi, DG Ousterout, IB Hilton, CA Gersbach
Nucleic acids research 42 (19), e147-e147, 2014
4252014
Enabling functional genomics with genome engineering
IB Hilton, CA Gersbach
Genome research 25 (10), 1442-1455, 2015
1192015
RNA-guided gene editing and gene regulation
CA Gersbach, IB Hilton, P Perez-Pinera, AM Kabadi, PI Thakore, ...
US Patent 10,704,060, 2020
1102020
Engineering the next generation of cell-based therapeutics
CJ Bashor, IB Hilton, H Bandukwala, DM Smith, O Veiseh
Nature Reviews Drug Discovery 21 (9), 655-675, 2022
1092022
mTOR inhibitors block Kaposi sarcoma growth by inhibiting essential autocrine growth factors and tumor angiogenesis
D Roy, SH Sin, A Lucas, R Venkataramanan, L Wang, A Eason, ...
Cancer research 73 (7), 2235-2246, 2013
802013
Distinct p53, p53: LANA, and LANA complexes in Kaposi's sarcoma-associated herpesvirus lymphomas
W Chen, IB Hilton, MR Staudt, CE Burd, DP Dittmer
Journal of virology 84 (8), 3898-3908, 2010
802010
Single C-to-T substitution using engineered APOBEC3G-nCas9 base editors with minimum genome-and transcriptome-wide off-target effects
S Lee, N Ding, Y Sun, T Yuan, J Li, Q Yuan, L Liu, J Yang, Q Wang, ...
Science advances 6 (29), eaba1773, 2020
752020
Transgenic mice for in vivo epigenome editing with CRISPR-based systems
MP Gemberling, K Siklenka, E Rodriguez, KR Tonn-Eisinger, A Barrera, ...
Nature methods 18 (8), 965-974, 2021
662021
CRISPR/Cas-based epigenome editing: advances, applications, and clinical utility
JH Goell, IB Hilton
Trends in Biotechnology 39 (7), 678-691, 2021
502021
Programmable human histone phosphorylation and gene activation using a CRISPR/Cas9-based chromatin kinase
J Li, B Mahata, M Escobar, J Goell, K Wang, P Khemka, IB Hilton
Nature Communications 12 (1), 896, 2021
452021
The open chromatin landscape of Kaposi's sarcoma-associated herpesvirus
IB Hilton, JM Simon, JD Lieb, IJ Davis, B Damania, DP Dittmer
Journal of virology 87 (21), 11831-11842, 2013
442013
The sound of silence: Transgene silencing in mammalian cell engineering
A Cabrera, HI Edelstein, F Glykofrydis, KS Love, S Palacios, J Tycko, ...
Cell Systems 13 (12), 950-973, 2022
302022
Temporal analysis suggests a reciprocal relationship between 3D chromatin structure and transcription
KSM Reed, ES Davis, ML Bond, A Cabrera, E Thulson, IY Quiroga, ...
Cell reports 41 (5), 2022
262022
RNA-guided gene editing and gene regulation
CA Gersbach, IB Hilton, P Perez-Pinera, AM Kabadi, PI Thakore, ...
US Patent 10,745,714, 2020
202020
Reversing post-infectious epigenetic-mediated immune suppression
CO Ontiveros, RS Guerra-Resendez, IB Hilton, LS Schlesinger, ...
Frontiers in immunology 12, 688132, 2021
192021
Systematic comparison of CRISPR-based transcriptional activators uncovers gene-regulatory features of enhancer–promoter interactions
K Wang, M Escobar, J Li, B Mahata, J Goell, S Shah, M Cluck, IB Hilton
Nucleic Acids Research 50 (14), 7842-7855, 2022
142022
Chemical control for CRISPR editing
IB Hilton, CA Gersbach
Nature Chemical Biology 13 (1), 2-3, 2017
102017
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