Sumit Handa
Sumit Handa
Singular Genomics
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Retroelement-guided protein diversification abounds in vast lineages of Bacteria and Archaea
BG Paul, D Burstein, CJ Castelle, S Handa, D Arambula, E Czornyj, ...
Nature microbiology 2 (6), 1-7, 2017
Targeted diversity generation by intraterrestrial archaea and archaeal viruses
BG Paul, SC Bagby, E Czornyj, D Arambula, S Handa, A Sczyrba, ...
Nature communications 6 (1), 6585, 2015
Diversity-generating retroelements: natural variation, classification and evolution inferred from a large-scale genomic survey
L Wu, M Gingery, M Abebe, D Arambula, E Czornyj, S Handa, H Khan, ...
Nucleic acids research 46 (1), 11-24, 2018
Thiamin Diphosphate Activation in 1-Deoxy-d-xylulose 5-Phosphate Synthase: Insights into the Mechanism and Underlying Intermolecular Interactions
JK White, S Handa, SL Vankayala, DJ Merkler, HL Woodcock
The journal of physical chemistry B 120 (37), 9922-9934, 2016
Mechanistic binding insights for 1-deoxy-d-Xylulose-5-Phosphate synthase, the enzyme catalyzing the first reaction of isoprenoid biosynthesis in the malaria-causing protists …
MR Battistini, C Shoji, S Handa, L Breydo, DJ Merkler
Protein expression and purification 120, 16-27, 2016
Template-assisted synthesis of adenine-mutagenized cDNA by a retroelement protein complex
S Handa, Y Jiang, S Tao, R Foreman, R Schinazi, JF Miller, P Ghosh
Nucleic Acid Research, 2018
Conservation of the C-type lectin fold for accommodating massive sequence variation in archaeal diversity-generating retroelements
S Handa, BG Paul, JF Miller, DL Valentine, P Ghosh
BMC structural biology 16, 1-9, 2016
Production of recombinant 1-deoxy-d-xylulose-5-phosphate synthase from Plasmodium vivax in Escherichia coli
S Handa, D Ramamoorthy, TJ Spradling, WC Guida, JH Adams, ...
FEBS Open Bio 3, 124-129, 2013
Mechanistic and structural analysis of a Drosophila melanogaster enzyme, arylalkylamine N-acetyltransferase like 7, an enzyme that catalyzes the formation of N …
DR Dempsey, KA Jeffries, S Handa, AM Carpenter, S Rodriguez-Ospina, ...
Biochemistry 54 (16), 2644-2658, 2015
Mechanistic studies of 1-deoxy-d-xylulose-5-phosphate synthase from Deinococcus radiodurans
S Handa, DR Dempsey, D Ramamoorthy, N Cook, WC Guida, ...
Biochemistry & molecular biology journal 4 (1), 2018
Crystal structure of a Thermus aquaticus diversity-generating retroelement variable protein
S Handa, KL Shaw, P Ghosh
PLoS One 14 (1), e0205618, 2019
Production of the catalytic core of human peptidylglycine α-hydroxylating monooxygenase (hPHMcc) in Escherichia coli
S Handa, TJ Spradling, DR Dempsey, DJ Merkler
Protein expression and purification 84 (1), 9-13, 2012
N-Acylethanolamines as novel alcohol dehydrogenase 3 substrates
M Ivkovic, DR Dempsey, S Handa, JH Hilton, EW Lowe Jr, DJ Merkler
Archives of biochemistry and biophysics 506 (2), 157-164, 2011
Determinants of adenine-mutagenesis in diversity-generating retroelements
S Handa, A Reyna, T Wiryaman, P Ghosh
Nucleic acids research 49 (2), 1033-1045, 2021
Plasmodium vivax 1-deoxy-D-xylulose-5-phosphate synthase: Homology Modeling, Domain Swapping, and Virtual Screening
D Ramamoorthy, S Handa, D Merkler, W Guida
J Data Mining Genomics Proteomics S 1, 2153-0602, 2014
Targeting 1-Deoxy-D-xylulose-5-Phosphate Synthase (DXS) in Plasmodium Species for New Generation of Antimalarial
S Handa
Mol Biol 5 (175), 2, 2016
Structural and biochemical characterization of Leptospira interrogans Lsa45 reveals a penicillin-binding protein with esterase activity
JC Santos, S Handa, LGV Fernandes, L Bleicher, CA Gandin, ...
Process Biochemistry 125, 141-153, 2023
Determinants of Selective Fidelity in Diversity-Generating Retroelements
S Handa, A Reyna, T Wiryaman, P Ghosh
bioRxiv, 2020
Retroelement-guided protein diversification abounds in vast lineages of Bacteria and
BG Paul, D Burstein, CJ Castelle, S Handa, D Arambula, E Czornyj, ...
Archaea 6, 1-7, 2017
Structural Requirements for Reverse Transcription by a Diversity-generating Retroelement
S Handa, T Biswas, J Chakraborty, G Ghosh, BG Paul, P Ghosh
bioRxiv, 2023.10. 23.563531, 2023
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