| Hypoxia enhances migration and invasion in glioblastoma by promoting a mesenchymal shift mediated by the HIF1α–ZEB1 axis JV Joseph, S Conroy, K Pavlov, P Sontakke, T Tomar, E Eggens-Meijer, ... Cancer letters 359 (1), 107-116, 2015 | 314 | 2015 |
| TGF-β is an inducer of ZEB1-dependent mesenchymal transdifferentiation in glioblastoma that is associated with tumor invasion JV Joseph, S Conroy, T Tomar, E Eggens-Meijer, K Bhat, S Copray, ... Cell death & disease 5 (10), e1443-e1443, 2014 | 197 | 2014 |
| Selective targeting of interferon γ to stromal fibroblasts and pericytes as a novel therapeutic approach to inhibit angiogenesis and tumor growth R Bansal, T Tomar, A Östman, K Poelstra, J Prakash Molecular cancer therapeutics 11 (11), 2419-2428, 2012 | 64 | 2012 |
| Biobanking of patient and patient-derived xenograft ovarian tumour tissue: efficient preservation with low and high fetal calf serum based methods NG Alkema, T Tomar, EW Duiker, G Jan Meersma, H Klip, ... Scientific reports 5 (1), 14495, 2015 | 56 | 2015 |
| TGF-β promotes microtube formation in glioblastoma through thrombospondin 1 JV Joseph, CR Magaut, S Storevik, LH Geraldo, T Mathivet, AMD Latif, ... Neuro-Oncology, 2021 | 48 | 2021 |
| Serum-induced differentiation of glioblastoma neurospheres leads to enhanced migration/invasion capacity that is associated with increased MMP9 JV Joseph, IAM Roosmalen, E Busschers, T Tomar, S Conroy, ... PLoS One 10 (12), e0145393, 2015 | 47 | 2015 |
| Integrative kinome profiling identifies mTORC1/2 inhibition as treatment strategy in ovarian clear cell carcinoma JJ Caumanns, K Berns, GBA Wisman, RSN Fehrmann, T Tomar, H Klip, ... Clinical Cancer Research 24 (16), 3928-3940, 2018 | 45 | 2018 |
| Methylome analysis of extreme chemoresponsive patients identifies novel markers of platinum sensitivity in high-grade serous ovarian cancer T Tomar, NG Alkema, L Schreuder, GJ Meersma, T De Meyer, ... Bmc Medicine 15, 1-16, 2017 | 44 | 2017 |
| Checkpoint kinase 2 (Chk2) supports sensitivity to platinum-based treatment in high grade serous ovarian cancer NG Alkema, T Tomar, AGJ Van Der Zee, M Everts, GJ Meersma, ... Gynecologic oncology 133 (3), 591-598, 2014 | 42 | 2014 |
| Genome-wide methylation profiling of ovarian cancer patient-derived xenografts treated with the demethylating agent decitabine identifies novel epigenetically regulated genes … T Tomar, S de Jong, NG Alkema, RL Hoekman, GJ Meersma, HG Klip, ... Genome medicine 8, 1-15, 2016 | 39 | 2016 |
| Antibody-free LC-MS/MS quantification of rhTRAIL in human and mouse serum D Wilffert, CR Reis, J Hermans, N Govorukhina, T Tomar, S de Jong, ... Analytical chemistry 85 (22), 10754-10760, 2013 | 37 | 2013 |
| Combined inhibition of SHP2 and MEK is effective in models of NF1-deficient malignant peripheral nerve sheath tumors J Wang, K Pollard, AN Allen, T Tomar, D Pijnenburg, Z Yao, FJ Rodriguez, ... Cancer research 80 (23), 5367-5379, 2020 | 33 | 2020 |
| Kinome array profiling of patient-derived pancreatic ductal adenocarcinoma identifies differentially active protein tyrosine kinases JF Creeden, K Alganem, AS Imami, FC Brunicardi, SH Liu, R Shukla, ... International journal of molecular sciences 21 (22), 8679, 2020 | 28 | 2020 |
| Identification of novel substrates for cGMP dependent protein kinase (PKG) through kinase activity profiling to understand its putative role in inherited retinal degeneration A Roy, J Groten, V Marigo, T Tomar, R Hilhorst International Journal of Molecular Sciences 22 (3), 1180, 2021 | 17 | 2021 |
| Protective effect of rosiglitazone on kidney function in high-fat challenged human-CRP transgenic mice: a possible role for adiponectin and miR-21? MC Morrison, GK Yakala, W Liang, PY Wielinga, K Salic, A van Koppen, ... Scientific Reports 7 (1), 2915, 2017 | 17 | 2017 |
| Kinase activity profiling identifies putative downstream targets of cGMP/PKG signaling in inherited retinal neurodegeneration A Roy, A Tolone, R Hilhorst, J Groten, T Tomar, F Paquet-Durand Cell Death Discovery 8 (1), 93, 2022 | 15 | 2022 |
| Emerging kinase therapeutic targets in pancreatic ductal adenocarcinoma and pancreatic cancer desmoplasia JF Creeden, K Alganem, AS Imami, ND Henkel, FC Brunicardi, SH Liu, ... International Journal of Molecular Sciences 21 (22), 8823, 2020 | 11 | 2020 |
| KRSA: An R package and R Shiny web application for an end-to-end upstream kinase analysis of kinome array data EAK DePasquale, K Alganem, E Bentea, N Nawreen, JL McGuire, ... PloS one 16 (12), e0260440, 2021 | 8 | 2021 |
| The PKG Inhibitor CN238 Affords Functional Protection of Photoreceptors and Ganglion Cells against Retinal Degeneration A Tolone, W Haq, A Fachinger, A Roy, S Kesh, A Rentsch, ... International Journal of Molecular Sciences 24 (20), 15277, 2023 | 2 | 2023 |
| Chick fetal organ spheroids as a model to study development and disease S Dakhel, WIL Davies, JV Joseph, T Tomar, S Remeseiro, L Gunhaga BMC Molecular and Cell Biology 22, 1-17, 2021 | 2 | 2021 |
Steven de JongProfessor of Preclinical and Translational Oncology, University Medical Center GroningenGeverifieerd e-mailadres voor umcg.nl
