Prof Nick Barker

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Hans CleversHubrecht Institute - UtrechtVerified email at hubrecht.eu
Peter J. PetersProfessor of NanoBiology, Maastricht University, The NetherlandsVerified email at maastrichtuniversity.nl
Hugo SnippertUniversity Medical Center Utrecht, The NetherlandsVerified email at umcutrecht.nl
Daniel E StangeTU DresdenVerified email at uniklinikum-dresden.de
Sato ToshiroKeio UniversityVerified email at a7.keio.jp
Pat J MorinDeputy Scientific Director, Ludwig Institute for Cancer ResearchVerified email at lcr.org
Bert VogelsteinJohns HopkinsVerified email at jhmi.edu
Kenneth KinzlerJohns Hopkins UniversityVerified email at jhmi.edu
Maria KasperDept of Cell and Molecular Biology, Karolinska InstitutetVerified email at ki.se
Alexander van OudenaardenHubrecht InstituteVerified email at hubrecht.eu
Bon-Kyoung KooInstitute of Molecular Biotechnology (IMBA) - The Austrian Academy of SciencesVerified email at imba.oeaw.ac.at
Nicholas A WrightProfessor of Histopathology, Queen Mary University of LondonVerified email at qmul.ac.uk
Jacco van RheenenProfessor at the UMC utrecht and group leader Netherlands Cancer InstituteVerified email at nki.nl
Prof. Dr. Bruno REVERSADEGIS & IMCB @ A*STAR (Singapore) & SMI @ KAUST (Saudi Arabia)Verified email at reversade.com
N. Ray DunnPrincipal Investigator, Institute of Medical BiologyVerified email at imb.a-star.edu.sg
Giulia RancatiPrincipal Investigator, Institute of Medical BiologyVerified email at imb.a-star.edu.sg
Brian BurkeASRL, SingaporeVerified email at asrl.a-star.edu.sg
Colin L Stewart
Leah A. VardyA*STAR Skin Research Labs, A*STAR, SingaporeVerified email at asrl.a-star.edu.sg
Thomas DawsonSenior Principal Investigator, Singapore Agency for Science, Technology, and ResearchVerified email at imb.a-star.edu.sg

Prof Nick Barker

A-STAR Institute of Molecular and Cellular Biology, Singapore

Verified email at imcb.a-star.edu.sg

stem cells cancer


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Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche T Sato, RG Vries, HJ Snippert, M Van De Wetering, N Barker, DE Stange, ... Nature 459 (7244), 262-265, 2009	5846	2009
Identification of stem cells in small intestine and colon by marker gene Lgr5 N Barker, JH Van Es, J Kuipers, P Kujala, M Van Den Born, M Cozijnsen, ... Nature 449 (7165), 1003-1007, 2007	5741	2007
Activation of β-catenin-Tcf signaling in colon cancer by mutations in β-catenin or APC PJ Morin, AB Sparks, V Korinek, N Barker, H Clevers, B Vogelstein, ... Science 275 (5307), 1787-1790, 1997	4997	1997
Constitutive transcriptional activation by a β-catenin-Tcf complex in APC−/− colon carcinoma V Korinek, N Barker, PJ Morin, D Van Wichen, R De Weger, KW Kinzler, ... Science 275 (5307), 1784-1787, 1997	4076	1997
Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts T Sato, JH Van Es, HJ Snippert, DE Stange, RG Vries, M Van Den Born, ... Nature 469 (7330), 415-418, 2011	2502	2011
Crypt stem cells as the cells-of-origin of intestinal cancer N Barker, RA Ridgway, JH Van Es, M Van De Wetering, H Begthel, ... Nature 457 (7229), 608-611, 2009	2296	2009
Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4 V Korinek, N Barker, P Moerer, E van Donselaar, G Huls, PJ Peters, ... Nature genetics 19 (4), 379-383, 1998	1957	1998
Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells HJ Snippert, LG Van Der Flier, T Sato, JH Van Es, M Van Den Born, ... Cell 143 (1), 134-144, 2010	1891	2010
Lgr5^+ve Stem Cells Drive Self-Renewal in the Stomach and Build Long-Lived Gastric Units In Vitro N Barker, M Huch, P Kujala, M van de Wetering, HJ Snippert, JH van Es, ... Cell stem cell 6 (1), 25-36, 2010	1604	2010
Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling W De Lau, N Barker, TY Low, BK Koo, VSW Li, H Teunissen, P Kujala, ... Nature 476 (7360), 293-297, 2011	1289	2011
Organoids as an in vitro model of human development and disease A Fatehullah, SH Tan, N Barker Nature cell biology 18 (3), 246-254, 2016	1229	2016
Adult intestinal stem cells: critical drivers of epithelial homeostasis and regeneration N Barker Nature reviews Molecular cell biology 15 (1), 19-33, 2014	1225	2014
Lgr5 marks cycling, yet long-lived, hair follicle stem cells V Jaks, N Barker, M Kasper, JH Van Es, HJ Snippert, H Clevers, ... Nature genetics 40 (11), 1291-1299, 2008	1053	2008
Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties S Schwitalla, AA Fingerle, P Cammareri, T Nebelsiek, SI Göktuna, ... Cell 152 (1-2), 25-38, 2013	1047	2013
Mining the Wnt pathway for cancer therapeutics N Barker, H Clevers Nature reviews Drug discovery 5 (12), 997-1014, 2006	983	2006
Functional interaction between ß-catenin and FOXO in oxidative stress signaling MAG Essers, LMM de Vries-Smits, N Barker, PE Polderman, ... Science 308 (5725), 1181-1184, 2005	885	2005
Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin HJ Snippert, A Haegebarth, M Kasper, V Jaks, JH van Es, N Barker, ... Science 327 (5971), 1385-1389, 2010	821	2010
The intestinal stem cell N Barker, M Van De Wetering, H Clevers Genes & development 22 (14), 1856-1864, 2008	783	2008
The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent ‘+ 4’cell markers J Muñoz, DE Stange, AG Schepers, M Van De Wetering, BK Koo, ... The EMBO journal 31 (14), 3079-3091, 2012	770	2012
The TAK1–NLK–MAPK-related pathway antagonizes signalling between β-catenin and transcription factor TCF T Ishitani, J Ninomiya-Tsuji, S Nagai, M Nishita, M Meneghini, N Barker, ... Nature 399 (6738), 798-802, 1999	768	1999

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