Prof Nick Barker
Prof Nick Barker
A-STAR Institute of Molecular and Cellular Biology, Singapore
Verified email at
Cited by
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Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche
T Sato, RG Vries, HJ Snippert, M Van De Wetering, N Barker, DE Stange, ...
Nature 459 (7244), 262-265, 2009
Identification of stem cells in small intestine and colon by marker gene Lgr5
N Barker, JH Van Es, J Kuipers, P Kujala, M Van Den Born, M Cozijnsen, ...
Nature 449 (7165), 1003-1007, 2007
Activation of β-catenin-Tcf signaling in colon cancer by mutations in β-catenin or APC
PJ Morin, AB Sparks, V Korinek, N Barker, H Clevers, B Vogelstein, ...
Science 275 (5307), 1787-1790, 1997
Constitutive transcriptional activation by a β-catenin-Tcf complex in APC−/− colon carcinoma
V Korinek, N Barker, PJ Morin, D Van Wichen, R De Weger, KW Kinzler, ...
Science 275 (5307), 1784-1787, 1997
Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts
T Sato, JH Van Es, HJ Snippert, DE Stange, RG Vries, M Van Den Born, ...
Nature 469 (7330), 415-418, 2011
Crypt stem cells as the cells-of-origin of intestinal cancer
N Barker, RA Ridgway, JH Van Es, M Van De Wetering, H Begthel, ...
Nature 457 (7229), 608-611, 2009
Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4
V Korinek, N Barker, P Moerer, E van Donselaar, G Huls, PJ Peters, ...
Nature genetics 19 (4), 379-383, 1998
Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells
HJ Snippert, LG Van Der Flier, T Sato, JH Van Es, M Van Den Born, ...
Cell 143 (1), 134-144, 2010
Lgr5+ ve stem cells drive self-renewal in the stomach and build long-lived gastric units in vitro
N Barker, M Huch, P Kujala, M van de Wetering, HJ Snippert, JH van Es, ...
Cell stem cell 6 (1), 25-36, 2010
Organoids as an in vitro model of human development and disease
A Fatehullah, SH Tan, N Barker
Nature cell biology 18 (3), 246-254, 2016
Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling
W De Lau, N Barker, TY Low, BK Koo, VSW Li, H Teunissen, P Kujala, ...
Nature 476 (7360), 293-297, 2011
Adult intestinal stem cells: critical drivers of epithelial homeostasis and regeneration
N Barker
Nature reviews Molecular cell biology 15 (1), 19-33, 2014
Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties
S Schwitalla, AA Fingerle, P Cammareri, T Nebelsiek, SI G÷ktuna, ...
Cell 152 (1), 25-38, 2013
Lgr5 marks cycling, yet long-lived, hair follicle stem cells
V Jaks, N Barker, M Kasper, JH Van Es, HJ Snippert, H Clevers, ...
Nature genetics 40 (11), 1291-1299, 2008
Mining the Wnt pathway for cancer therapeutics
N Barker, H Clevers
Nature reviews Drug discovery 5 (12), 997-1014, 2006
Functional interaction between ▀-catenin and FOXO in oxidative stress signaling
MAG Essers, LMM de Vries-Smits, N Barker, PE Polderman, ...
Science 308 (5725), 1181-1184, 2005
Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin
HJ Snippert, A Haegebarth, M Kasper, V Jaks, JH van Es, N Barker, ...
Science 327 (5971), 1385-1389, 2010
The intestinal stem cell
N Barker, M Van De Wetering, H Clevers
Genes & development 22 (14), 1856-1864, 2008
Dll1+ secretory progenitor cells revert to stem cells upon crypt damage
JH Van Es, T Sato, M Van De Wetering, A Lyubimova, AN Yee Nee, ...
Nature cell biology 14 (10), 1099-1104, 2012
The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent ‘+ 4’cell markers
J Mu˝oz, DE Stange, AG Schepers, M Van De Wetering, BK Koo, ...
The EMBO journal 31 (14), 3079-3091, 2012
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