Prof Nick Barker

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Hans CleversHubrecht Institute - UtrechtVerified email at hubrecht.eu
Peter J. PetersProfessor of NanoBiology, Maastricht University, The NetherlandsVerified email at maastrichtuniversity.nl
Hugo SnippertUniversity Medical Center Utrecht, The NetherlandsVerified email at umcutrecht.nl
Daniel E StangeTU DresdenVerified email at uniklinikum-dresden.de
Pekka KujalaNetherlands Cancer Institute; Hubrecht InstituteVerified email at nki.nl
Sato ToshiroKeio UniversityVerified email at a7.keio.jp
Pat J MorinExec. Director, Strategic Alliances, Abramson Cancer Center, University of PennsylvaniaVerified email at upenn.edu
Bert VogelsteinJohns HopkinsVerified email at jhmi.edu
Kenneth KinzlerJohns Hopkins UniversityVerified email at jhmi.edu
Maria KasperDept of Cell and Molecular Biology, Karolinska InstitutetVerified email at ki.se
Alexander van OudenaardenHubrecht InstituteVerified email at hubrecht.eu
Bon-Kyoung KooInstitute of Molecular Biotechnology (IMBA) - The Austrian Academy of SciencesVerified email at imba.oeaw.ac.at
Nicholas A WrightProfessor of Histopathology, Queen Mary University of LondonVerified email at qmul.ac.uk
Jacco van RheenenProfessor at the UMC utrecht and group leader Netherlands Cancer InstituteVerified email at nki.nl
Prof. Dr. Bruno REVERSADEGIS & IMCB, A*STAR, SingaporeVerified email at reversade.com
N. Ray DunnPrincipal Investigator, Institute of Medical BiologyVerified email at imb.a-star.edu.sg
Giulia RancatiPrincipal Investigator, Institute of Medical BiologyVerified email at imb.a-star.edu.sg
Brian BurkeASRL, SingaporeVerified email at asrl.a-star.edu.sg
Colin L Stewart
Leah A. VardyInstitute of Medical Biology, A*STAR, SingaporeVerified email at imb.a-star.edu.sg

Prof Nick Barker

A-STAR Institute of Molecular and Cellular Biology, Singapore

Verified email at imcb.a-star.edu.sg

stem cells cancer


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Identification of stem cells in small intestine and colon by marker gene Lgr5 N Barker, JH Van Es, J Kuipers, P Kujala, M Van Den Born, M Cozijnsen, ... Nature 449 (7165), 1003-1007, 2007	4978	2007
Activation of β-catenin-Tcf signaling in colon cancer by mutations in β-catenin or APC PJ Morin, AB Sparks, V Korinek, N Barker, H Clevers, B Vogelstein, ... Science 275 (5307), 1787-1790, 1997	4807	1997
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche T Sato, RG Vries, HJ Snippert, M Van De Wetering, N Barker, DE Stange, ... Nature 459 (7244), 262-265, 2009	4524	2009
Constitutive transcriptional activation by a β-catenin-Tcf complex in APC−/− colon carcinoma V Korinek, N Barker, PJ Morin, D Van Wichen, R De Weger, KW Kinzler, ... Science 275 (5307), 1784-1787, 1997	3924	1997
Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts T Sato, JH Van Es, HJ Snippert, DE Stange, RG Vries, M Van Den Born, ... Nature 469 (7330), 415-418, 2011	2076	2011
Crypt stem cells as the cells-of-origin of intestinal cancer N Barker, RA Ridgway, JH Van Es, M Van De Wetering, H Begthel, ... Nature 457 (7229), 608-611, 2009	2055	2009
Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4 V Korinek, N Barker, P Moerer, E van Donselaar, G Huls, PJ Peters, ... Nature genetics 19 (4), 379-383, 1998	1841	1998
Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells HJ Snippert, LG Van Der Flier, T Sato, JH Van Es, M Van Den Born, ... Cell 143 (1), 134-144, 2010	1628	2010
Lgr5^+ve Stem Cells Drive Self-Renewal in the Stomach and Build Long-Lived Gastric Units In Vitro N Barker, M Huch, P Kujala, M van de Wetering, HJ Snippert, JH van Es, ... Cell stem cell 6 (1), 25-36, 2010	1351	2010
Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling W De Lau, N Barker, TY Low, BK Koo, VSW Li, H Teunissen, P Kujala, ... Nature 476 (7360), 293-297, 2011	1133	2011
Lgr5 marks cycling, yet long-lived, hair follicle stem cells V Jaks, N Barker, M Kasper, JH Van Es, HJ Snippert, H Clevers, ... Nature genetics 40 (11), 1291-1299, 2008	966	2008
Adult intestinal stem cells: critical drivers of epithelial homeostasis and regeneration N Barker Nature reviews Molecular cell biology 15 (1), 19-33, 2014	963	2014
Organoids as an in vitro model of human development and disease A Fatehullah, SH Tan, N Barker Nature cell biology 18 (3), 246-254, 2016	938	2016
Mining the Wnt pathway for cancer therapeutics N Barker, H Clevers Nature reviews Drug discovery 5 (12), 997-1014, 2006	925	2006
Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties S Schwitalla, AA Fingerle, P Cammareri, T Nebelsiek, SI Göktuna, ... Cell 152 (1-2), 25-38, 2013	895	2013
Functional interaction between ß-catenin and FOXO in oxidative stress signaling MAG Essers, LMM de Vries-Smits, N Barker, PE Polderman, ... Science 308 (5725), 1181-1184, 2005	816	2005
The TAK1–NLK–MAPK-related pathway antagonizes signalling between β-catenin and transcription factor TCF T Ishitani, J Ninomiya-Tsuji, S Nagai, M Nishita, M Meneghini, N Barker, ... Nature 399 (6738), 798-802, 1999	744	1999
Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin HJ Snippert, A Haegebarth, M Kasper, V Jaks, JH van Es, N Barker, ... Science 327 (5971), 1385-1389, 2010	743	2010
The intestinal stem cell N Barker, M van de Wetering, H Clevers Genes & development 22 (14), 1856-1864, 2008	721	2008
Transcription factor achaete scute-like 2 controls intestinal stem cell fate LG van der Flier, ME van Gijn, P Hatzis, P Kujala, A Haegebarth, ... Cell 136 (5), 903-912, 2009	678	2009

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