Prof Nick Barker

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Hans CleversHubrecht Institute - UtrechtVerified email at hubrecht.eu
Johan H. van EsKNAW Hubrecht InstituteVerified email at hubrecht.eu
Hugo SnippertUniversity Medical Center Utrecht, The NetherlandsVerified email at umcutrecht.nl
Peter J. PetersProfessor of NanoBiology, Maastricht University, The NetherlandsVerified email at maastrichtuniversity.nl
Daniel E StangeTU DresdenVerified email at uniklinikum-dresden.de
Vladimir KorinekVerified email at img.cas.cz
Pekka KujalaEM scientist, UMC UtrechtVerified email at umcutrecht.nl
Sato ToshiroKeio UniversityVerified email at a7.keio.jp
Pat J MorinDeputy Scientific Director, Ludwig Institute for Cancer ResearchVerified email at lcr.org
Kenneth KinzlerJohns Hopkins UniversityVerified email at jhmi.edu
Bert VogelsteinJohns HopkinsVerified email at jhmi.edu
Marc LeushackeSkin Research Institute of Singapore, A*STARVerified email at sris.a-star.edu.sg
Maria KasperDept of Cell and Molecular Biology, Karolinska InstitutetVerified email at ki.se
Viljar JaksAssociated professor, University of TartuVerified email at ut.ee
Alexander van OudenaardenHubrecht InstituteVerified email at hubrecht.eu
Bon-Kyoung KooCenter for Genome Engineering (CGE), Institute for Basic Science (IBS)Verified email at ibs.re.kr
Meritxell HuchMax Planck Institute of Molecular Cell Biology and GeneticsVerified email at mpi-cbg.de
Nicholas A WrightProfessor of Histopathology, Queen Mary University of LondonVerified email at qmul.ac.uk
Jacco van RheenenProfessor at the UMC utrecht and group leader Netherlands Cancer InstituteVerified email at nki.nl
Prof. Dr. Bruno REVERSADEGIS & IMCB @ A*STAR (Singapore) & SMI @ KAUST (Saudi Arabia)Verified email at reversade.com

Prof Nick Barker

A-STAR Institute of Molecular and Cellular Biology, Singapore

Verified email at imcb.a-star.edu.sg

stem cells cancer


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Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche T Sato, RG Vries, HJ Snippert, M Van De Wetering, N Barker, DE Stange, ... Nature 459 (7244), 262-265, 2009	7261	2009
Identification of stem cells in small intestine and colon by marker gene Lgr5 N Barker, JH Van Es, J Kuipers, P Kujala, M Van Den Born, M Cozijnsen, ... Nature 449 (7165), 1003-1007, 2007	6470	2007
Activation of β-catenin-Tcf signaling in colon cancer by mutations in β-catenin or APC PJ Morin, AB Sparks, V Korinek, N Barker, H Clevers, B Vogelstein, ... Science 275 (5307), 1787-1790, 1997	5165	1997
Constitutive transcriptional activation by a β-catenin-Tcf complex in APC−/− colon carcinoma V Korinek, N Barker, PJ Morin, D Van Wichen, R De Weger, KW Kinzler, ... Science 275 (5307), 1784-1787, 1997	4214	1997
Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts T Sato, JH Van Es, HJ Snippert, DE Stange, RG Vries, M Van Den Born, ... Nature 469 (7330), 415-418, 2011	2848	2011
Crypt stem cells as the cells-of-origin of intestinal cancer N Barker, RA Ridgway, JH Van Es, M Van De Wetering, H Begthel, ... Nature 457 (7229), 608-611, 2009	2509	2009
Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells HJ Snippert, LG Van Der Flier, T Sato, JH Van Es, M Van Den Born, ... Cell 143 (1), 134-144, 2010	2099	2010
Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4 V Korinek, N Barker, P Moerer, E van Donselaar, G Huls, PJ Peters, ... Nature genetics 19 (4), 379-383, 1998	2060	1998
Lgr5+ ve stem cells drive self-renewal in the stomach and build long-lived gastric units in vitro N Barker, M Huch, P Kujala, M van de Wetering, HJ Snippert, JH van Es, ... Cell stem cell 6 (1), 25-36, 2010	1797	2010
Organoids as an in vitro model of human development and disease A Fatehullah, SH Tan, N Barker Nature cell biology 18 (3), 246-254, 2016	1567	2016
Adult intestinal stem cells: critical drivers of epithelial homeostasis and regeneration N Barker Nature reviews Molecular cell biology 15 (1), 19-33, 2014	1479	2014
Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling W De Lau, N Barker, TY Low, BK Koo, VSW Li, H Teunissen, P Kujala, ... Nature 476 (7360), 293-297, 2011	1451	2011
Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties S Schwitalla, AA Fingerle, P Cammareri, T Nebelsiek, SI Göktuna, ... Cell 152 (1), 25-38, 2013	1191	2013
Lgr5 marks cycling, yet long-lived, hair follicle stem cells V Jaks, N Barker, M Kasper, JH Van Es, HJ Snippert, H Clevers, ... Nature genetics 40 (11), 1291-1299, 2008	1135	2008
Mining the Wnt pathway for cancer therapeutics N Barker, H Clevers Nature reviews Drug discovery 5 (12), 997-1014, 2006	1019	2006
Functional interaction between β-catenin and FOXO in oxidative stress signaling MAG Essers, LMM de Vries-Smits, N Barker, PE Polderman, ... Science 308 (5725), 1181-1184, 2005	920	2005
Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin HJ Snippert, A Haegebarth, M Kasper, V Jaks, JH van Es, N Barker, ... Science 327 (5971), 1385-1389, 2010	902	2010
The intestinal stem cell N Barker, M Van De Wetering, H Clevers Genes & development 22 (14), 1856-1864, 2008	878	2008
Dll1⁺ secretory progenitor cells revert to stem cells upon crypt damage JH Van Es, T Sato, M Van De Wetering, A Lyubimova, AN Yee Nee, ... Nature cell biology 14 (10), 1099-1104, 2012	860	2012
The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent ‘+ 4’cell markers J Muñoz, DE Stange, AG Schepers, M Van De Wetering, BK Koo, ... The EMBO journal 31 (14), 3079-3091, 2012	853	2012

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