Prof Nick Barker

Cited by

	All	Since 2016
Citations	44026	18591
h-index	64	53
i10-index	89	86

3900

1950

975

2925

199819992000200120022003200420052006200720082009201020112012201320142015201620172018201920202021258 492 512 662 712 649 754 711 677 830 1024 1210 1671 2219 2695 3213 3240 3458 3517 3831 3788 3450 3867 127

Co-authors

Hans CleversHubrecht Institute - UtrechtVerified email at hubrecht.eu
Peter J. PetersProfessor of NanoBiology, Maastricht University, The NetherlandsVerified email at maastrichtuniversity.nl
Hugo SnippertUniversity Medical Center Utrecht, The NetherlandsVerified email at umcutrecht.nl
Daniel E StangeTU DresdenVerified email at uniklinikum-dresden.de
Pekka KujalaNetherlands Cancer Institute; Hubrecht InstituteVerified email at nki.nl
Sato ToshiroKeio UniversityVerified email at a7.keio.jp
Pat J MorinExec. Director, Strategic Alliances, Abramson Cancer Center, University of PennsylvaniaVerified email at upenn.edu
Bert VogelsteinJohns HopkinsVerified email at jhmi.edu
Kenneth KinzlerJohns Hopkins UniversityVerified email at jhmi.edu
Maria KasperDept of Biosciences and Nutrition, Karolinska InstitutetVerified email at ki.se
Alexander van OudenaardenHubrecht InstituteVerified email at hubrecht.eu
Bon-Kyoung KooIMBA - The Austrian Academy of SciencesVerified email at imba.oeaw.ac.at
Nicholas A WrightProfessor of Histopathology, Queen Mary University of LondonVerified email at qmul.ac.uk
Jacco van RheenenProfessor at the UMC utrecht and group leader Netherlands Cancer InstituteVerified email at nki.nl
Prof. Dr. Bruno REVERSADEGIS & IMCB, A*STAR, SingaporeVerified email at reversade.com
N. Ray DunnPrincipal Investigator, Institute of Medical BiologyVerified email at imb.a-star.edu.sg
Giulia RancatiPrincipal Investigator, Institute of Medical BiologyVerified email at imb.a-star.edu.sg
Brian BurkeInstitute of Medical Biology, SingaporeVerified email at imb.a-star.edu.sg
Colin L Stewart
Leah A. VardyInstitute of Medical Biology, A*STAR, SingaporeVerified email at imb.a-star.edu.sg

Prof Nick Barker

A-STAR Institute of Molecular and Cellular Biology, Singapore

Verified email at imcb.a-star.edu.sg

stem cells cancer


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Activation of β-catenin-Tcf signaling in colon cancer by mutations in β-catenin or APC PJ Morin, AB Sparks, V Korinek, N Barker, H Clevers, B Vogelstein, ... Science 275 (5307), 1787-1790, 1997	4571	1997
Identification of stem cells in small intestine and colon by marker gene Lgr5 N Barker, JH Van Es, J Kuipers, P Kujala, M Van Den Born, M Cozijnsen, ... Nature 449 (7165), 1003-1007, 2007	4561	2007
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche T Sato, RG Vries, HJ Snippert, M Van De Wetering, N Barker, DE Stange, ... Nature 459 (7244), 262-265, 2009	3894	2009
Constitutive transcriptional activation by a β-catenin-Tcf complex in APC−/− colon carcinoma V Korinek, N Barker, PJ Morin, D Van Wichen, R De Weger, KW Kinzler, ... Science 275 (5307), 1784-1787, 1997	3753	1997
Crypt stem cells as the cells-of-origin of intestinal cancer N Barker, RA Ridgway, JH Van Es, M Van De Wetering, H Begthel, ... Nature 457 (7229), 608-611, 2009	1933	2009
Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts T Sato, JH Van Es, HJ Snippert, DE Stange, RG Vries, M Van Den Born, ... Nature 469 (7330), 415-418, 2011	1861	2011
Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4 V Korinek, N Barker, P Moerer, E van Donselaar, G Huls, PJ Peters, ... Nature genetics 19 (4), 379-383, 1998	1776	1998
Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells HJ Snippert, LG Van Der Flier, T Sato, JH Van Es, M Van Den Born, ... Cell 143 (1), 134-144, 2010	1483	2010
Lgr5^+ve Stem Cells Drive Self-Renewal in the Stomach and Build Long-Lived Gastric Units In Vitro N Barker, M Huch, P Kujala, M van de Wetering, HJ Snippert, JH van Es, ... Cell stem cell 6 (1), 25-36, 2010	1224	2010
Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling W De Lau, N Barker, TY Low, BK Koo, VSW Li, H Teunissen, P Kujala, ... Nature 476 (7360), 293-297, 2011	1052	2011
Lgr5 marks cycling, yet long-lived, hair follicle stem cells V Jaks, N Barker, M Kasper, JH Van Es, HJ Snippert, H Clevers, ... Nature genetics 40 (11), 1291, 2008	919	2008
Mining the Wnt pathway for cancer therapeutics N Barker, H Clevers Nature reviews Drug discovery 5 (12), 997-1014, 2006	889	2006
Adult intestinal stem cells: critical drivers of epithelial homeostasis and regeneration N Barker Nature reviews Molecular cell biology 15 (1), 19-33, 2014	818	2014
Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties S Schwitalla, AA Fingerle, P Cammareri, T Nebelsiek, SI Göktuna, ... Cell 152 (1-2), 25-38, 2013	802	2013
Functional interaction between ß-catenin and FOXO in oxidative stress signaling MAG Essers, LMM de Vries-Smits, N Barker, PE Polderman, ... Science 308 (5725), 1181-1184, 2005	771	2005
Organoids as an in vitro model of human development and disease A Fatehullah, SH Tan, N Barker Nature cell biology 18 (3), 246-254, 2016	752	2016
The TAK1–NLK–MAPK-related pathway antagonizes signalling between β-catenin and transcription factor TCF T Ishitani, J Ninomiya-Tsuji, S Nagai, M Nishita, M Meneghini, N Barker, ... Nature 399 (6738), 798-802, 1999	719	1999
Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin HJ Snippert, A Haegebarth, M Kasper, V Jaks, JH van Es, N Barker, ... Science 327 (5971), 1385-1389, 2010	694	2010
The intestinal stem cell N Barker, M van de Wetering, H Clevers Genes & development 22 (14), 1856-1864, 2008	684	2008
Transcription factor achaete scute-like 2 controls intestinal stem cell fate LG van der Flier, ME van Gijn, P Hatzis, P Kujala, A Haegebarth, ... Cell 136 (5), 903-912, 2009	648	2009

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