| Human iPSC-derived retinas recapitulate the fetal CRB1 CRB2 complex formation and demonstrate that photoreceptors and Müller glia are targets of AAV5 PM Quinn, TM Buck, AA Mulder, C Ohonin, CH Alves, RM Vos, M Bialecka, ... Stem Cell Reports 12 (5), 906-919, 2019 | 88 | 2019 |
| Recombinant Adeno-Associated Viral Vectors (rAAV)-Vector Elements in Ocular Gene Therapy Clinical Trials and Transgene Expression and Bioactivity Assays TM Buck, J Wijnholds Int. J. Mol. Sci. 21 (12), 4197, 2020 | 70 | 2020 |
| Production of iPS-derived human retinal organoids for use in transgene expression assays PM Quinn, TM Buck, C Ohonin, HMM Mikkers, J Wijnholds Retinal Gene Therapy: Methods and Protocols, 261-273, 2018 | 26 | 2018 |
| AAV-CRB2 protects against vision loss in an inducible CRB1 retinitis pigmentosa mouse model TM Buck, RM Vos, CH Alves, J Wijnholds Molecular Therapy-Methods & Clinical Development 20, 423-441, 2021 | 23 | 2021 |
| AAV-mediated gene augmentation therapy of CRB1 patient-derived retinal organoids restores the histological and transcriptional retinal phenotype N Boon, X Lu, CA Andriessen, I Moustakas, TM Buck, C Freund, ... Stem cell reports 18 (5), 1123-1137, 2023 | 17 | 2023 |
| AAV serotype testing on cultured human donor retinal explants TM Buck, LP Pellissier, RM Vos, EHC van Dijk, CJF Boon, J Wijnholds Retinal Gene Therapy: Methods and Protocols, 275-288, 2018 | 17 | 2018 |
| Defining Phenotype, Tropism, and Retinal Gene Therapy Using Adeno-Associated Viral Vectors (AAVs) in New-Born Brown Norway Rats with a Spontaneous Mutation in Crb1 N Boon, CH Alves, AA Mulder, CA Andriessen, TM Buck, PMJ Quinn, ... International Journal of Molecular Sciences 22 (7), 3563, 2021 | 11 | 2021 |
| CRB1 is required for recycling by RAB11A+ vesicles in human retinal organoids TM Buck, PMJ Quinn, LP Pellissier, AA Mulder, A Jongejan, X Lu, N Boon, ... Stem cell reports 18 (9), 1793-1810, 2023 | 4 | 2023 |
| Sleep Deprivation Does not Change the Flash Electroretinogram in Wild-type and Opn4−/−Gnat1−/− Mice RA Schoonderwoerd, TM Buck, CA Andriessen, J Wijnholds, S Hattar, ... Journal of biological rhythms 37 (2), 216-221, 2022 | 3 | 2022 |
| Potency assay for AAV-gene vectors in human iPSCs-derived retinas and donor retinas TM Buck, PM Quinn, C Alves, E Van Dijk, C Ohonin, CJF Boon, ... Investigative Ophthalmology & Visual Science 58 (8), 4093-4093, 2017 | 3 | 2017 |
| Recapitulation of the human fetal crumbs complex in human iPSCs-derived retinas and retinal pigment epithelium PM Quinn, TM Buck, C Alves, C Ohonin, SMC de Sousa Lopes, H Mikkers, ... Investigative Ophthalmology & Visual Science 58 (8), 3758-3758, 2017 | 2 | 2017 |
| CRB1 gene therap coming of age: mechanistic insight and rAAV assa s on mouse & human retinal organoid models TM Buck Leiden University, 2022 | | 2022 |
| Exploring Retinal Gene Therapy Using Adeno-Associated Viral (AAV) Vectors in Crb1 Mutant Rats N Boon, CH Alves, AA Mulder, TM Buck, PMJ Quinn, CR Jost, J Wijnholds MOLECULAR THERAPY 28 (4), 268-268, 2020 | | 2020 |
| Pilot Study: AAV-CRB2 to Protect Against Blindness Due to Loss of CRB Proteins in Muller Glial Cells TM Buck, J Wijnholds MOLECULAR THERAPY 28 (4), 260-260, 2020 | | 2020 |
| Inner-and outer segments are required for efficient photoreceptor infection and expression in cultured human retina TM Buck, PM Quinn, C Boon, CHF Alves, J Wijnholds Investigative Ophthalmology & Visual Science 59 (9), 4540-4540, 2018 | | 2018 |
| Ablation of Crb2 Specifically in Mouse Photoreceptors with Crb1 loss in Müller Cells Mimics Leber Congenital Amaurosis TM Buck, PM Quinn, J Klooster, J Wijnholds Investigative Ophthalmology & Visual Science 57 (12), 1777-1777, 2016 | | 2016 |
| CRB1 gene therapy coming of age TM Buck | | |
Peter M.J. QuinnPrincipal Investigator and Associate Research ScientistGeverifieerd e-mailadres voor cumc.columbia.edu
