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Irina Bochkis
Irina Bochkis
Assistant Professor of Pharmacology, University of Virginia
Verified email at virginia.edu - Homepage
Title
Cited by
Cited by
Year
Glucocorticoid receptor-dependent gene regulatory networks
P Phuc Le, JR Friedman, J Schug, JE Brestelli, JB Parker, IM Bochkis, ...
PLoS genetics 1 (2), e16, 2005
2872005
Hepatocyte-specific ablation of Foxa2 alters bile acid homeostasis and results in endoplasmic reticulum stress
IM Bochkis, NE Rubins, P White, EE Furth, JR Friedman, KH Kaestner
Nature medicine 14 (8), 828-836, 2008
2042008
Changes in nucleosome occupancy associated with metabolic alterations in aged mammalian liver
IM Bochkis, D Przybylski, J Chen, A Regev
Cell reports 9 (3), 996-1006, 2014
792014
Genome-wide location analysis reveals distinct transcriptional circuitry by paralogous regulators Foxa1 and Foxa2
IM Bochkis, J Schug, DZ Ye, S Kurinna, SA Stratton, MC Barton, ...
PLoS genetics 8 (6), e1002770, 2012
542012
Genome-wide location analysis reveals distinct transcriptional circuitry by paralogous regulators Foxa1 and Foxa2
IM Bochkis, J Schug, DZ Ye, S Kurinna, SA Stratton, MC Barton, ...
PLoS genetics 8 (6), e1002770, 2012
542012
Impaired male fertility and atrophy of seminiferous tubules caused by haploinsufficiency for Foxa3
R Behr, SD Sackett, IM Bochkis, PP Le, KH Kaestner
Developmental biology 306 (2), 636-645, 2007
482007
Foxa2-dependent hepatic gene regulatory networks depend on physiological state
IM Bochkis, J Schug, NE Rubins, AR Chopra, BW O'Malley, KH Kaestner
Physiological genomics, 2009
322009
Bile acid-induced inflammatory signaling in mice lacking Foxa2 in the liver leads to activation of mTOR and age-onset obesity
IM Bochkis, S Shin, KH Kaestner
Molecular metabolism 2 (4), 447-456, 2013
292013
Hdac3, Setdb1, and Kap1 mark H3K9me3/H3K14ac bivalent regions in young and aged liver
AJ Price, MC Manjegowda, J Kain, S Anandh, IM Bochkis
Aging Cell 19 (2), e13092, 2020
272020
Changes at the nuclear lamina alter binding of pioneer factor Foxa2 in aged liver
H Whitton, LN Singh, MA Patrick, AJ Price, FG Osorio, C López‐Otín, ...
Aging Cell 17 (3), e12742, 2018
262018
Pioneer factor Foxa2 enables ligand-dependent activation of type II nuclear receptors FXR and LXRα
J Kain, X Wei, NA Reddy, AJ Price, C Woods, IM Bochkis
Molecular Metabolism 53, 101291, 2021
132021
Targeting oxidized phospholipids by AAV-based gene therapy in mice with established hepatic steatosis prevents progression to fibrosis
CM Upchurch, S Yeudall, CM Pavelec, D Merk, J Greulich, ...
Science Advances 8 (28), eabn0050, 2022
122022
Redistribution of lamina-associated domains reshapes binding of pioneer factor FOXA2 in development of nonalcoholic fatty liver disease
X Wei, MA Murphy, NA Reddy, Y Hao, TG Eggertsen, JJ Saucerman, ...
Genome Research 32 (11-12), 1981-1992, 2022
42022
Feeding desensitizes A1 adenosine receptors in adipose through FOXO1-mediated transcriptional regulation
ME Granade, SR Hargett, DS Lank, MC Lemke, MA Luse, BE Isakson, ...
Molecular Metabolism 63, 101543, 2022
22022
Pioneer Factor Foxa2 Mediates Chromatin Conformation Changes for Activation of Bile Acid Targets of FXR
Y Hao, L Han, A Wu, IM Bochkis
Cellular and Molecular Gastroenterology and Hepatology 17 (2), 237-249, 2024
2024
OR33-06 Pioneer Factor Foxa2 Mediates Chromatin Conformation Changes In Ligand-dependent Activation Of FXR
Y Hao, L Han, C Wu, I Bochkis
Journal of the Endocrine Society 7 (Supplement_1), bvad114. 1774, 2023
2023
Pioneer factor Foxa2 mediates chromatin conformation changes in ligand-dependent activation of nuclear receptor FXR
Y Hao, L Han, A Wu, IM Bochkis
bioRxiv, 2023.03. 06.531297, 2023
2023
AAV8-mediated expression of scFv-E06 to target oxidized phosphatidylcholines protects against hepatic fibrosis
C Upchurch, S Yeudall, C Pavelec, D Merk, J Greulich, M Manjegowda, ...
Free Radical Biology and Medicine 192, 93, 2022
2022
Virus‐induced Hepatic Expression of an Oxidized Phospholipid‐binding Antibody Fragment Prevents Initiation of Hepatic Steatosis and Progression to Fibrosis
CM Upchurch, S Yeudall, CM Pavelec, M Manjegowda, IM Bochkis, ...
The FASEB Journal 36, 2022
2022
Pioneer factor Foxa2 enables ligand-dependent activation of LXRα
J Kain, X Wei, AJ Price, C Woods, IM Bochkis
bioRxiv, 2020.04. 10.036061, 2020
2020
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Articles 1–20