Thomas Look
Thomas Look
Professor of Pediatrics, Harvard Medical School
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Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia
AP Weng, AA Ferrando, W Lee, JP Morris, LB Silverman, ...
Science 306 (5694), 269-271, 2004
Acute lymphoblastic leukemia
CH Pui, MV Relling, JR Downing
New England Journal of Medicine 350 (15), 1535-1548, 2004
Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma
SW Morris, MN Kirstein, MB Valentine, KG Dittmer, DN Shapiro, ...
Science 263 (5151), 1281-1284, 1994
Acute lymphoblastic leukaemia
CH Pui, LL Robison, AT Look
The Lancet 371 (9617), 1030-1043, 2008
The c-fms proto-oncogene product is related to the receptor for the mononuclear phagocyte growth factor, CSF 1
CJ Sherr, CW Rettenmier, R Sacca, MF Roussel, AT Look, ER Stanley
Cell 41 (3), 665-676, 1985
Oncogenic transcription factors in the human acute leukemias
AT Look
Science 278 (5340), 1059-1064, 1997
A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish
P Niethammer, C Grabher, AT Look, TJ Mitchison
Nature 459 (7249), 996-999, 2009
Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia
AA Ferrando, DS Neuberg, J Staunton, ML Loh, C Huard, SC Raimondi, ...
Cancer cell 1 (1), 75-87, 2002
Caspase 8 is deleted or silenced preferentially in childhood neuroblastomas with amplification of MYCN
T Teitz, T Wei, MB Valentine, EF Vanin, J Grenet, VA Valentine, FG Behm, ...
Nature medicine 6 (5), 529-535, 2000
Human aminopeptidase N is a receptor for human coronavirus 229E
CL Yeager, RA Ashmun, RK Williams, CB Cardellichio, LH Shapiro, ...
Nature 357 (6377), 420-422, 1992
NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth
T Palomero, WK Lim, DT Odom, ML Sulis, PJ Real, A Margolin, ...
Proceedings of the National Academy of Sciences 103 (48), 18261-18266, 2006
Hematology of infancy and childhood
DG Nathan, FA Oski
WB Saunders Co., Philadelphia, PA, 1987
Activating mutations in ALK provide a therapeutic target in neuroblastoma
RE George, T Sanda, M Hanna, S Fröhling, W Luther II, J Zhang, Y Ahn, ...
Nature 455 (7215), 975-978, 2008
Identification of breakpoints in t (8; 21) acute myelogenous leukemia and isolation of a fusion transcript, AML1/ETO, with similarity to Drosophila segmentation gene, runt
P Erickson, J Gao, KS Chang, T Look, E Whisenant, S Raimondi, ...
Clinical relevance of tumor cell ploidy and N-myc gene amplification in childhood neuroblastoma: a Pediatric Oncology Group study.
AT Look, FA Hayes, JJ Shuster, EC Douglass, RP Castleberry, ...
Journal of Clinical Oncology 9 (4), 581-591, 1991
FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to γ-secretase inhibitors
J O'Neil, J Grim, P Strack, S Rao, D Tibbitts, C Winter, J Hardwick, ...
The Journal of experimental medicine 204 (8), 1813-1824, 2007
BRAF mutations are sufficient to promote nevi formation and cooperate with p53 in the genesis of melanoma
EE Patton, HR Widlund, JL Kutok, KR Kopani, JF Amatruda, RD Murphey, ...
Current Biology 15 (3), 249-254, 2005
Chromosome 1p and 11q deletions and outcome in neuroblastoma
EF Attiyeh, WB London, YP Mossé, Q Wang, C Winter, D Khazi, ...
New England Journal of Medicine 353 (21), 2243-2253, 2005
The use of zebrafish to understand immunity
NS Trede, DM Langenau, D Traver, AT Look, LI Zon
Immunity 20 (4), 367-379, 2004
The retinoblastoma protein binds to a family of E2F transcription factors
JA Lees, M Saito, M Vidal, M Valentine, T Look, E Harlow, N Dyson, ...
Molecular and cellular biology 13 (12), 7813-7825, 1993
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