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Kees Bronsema
Kees Bronsema
ICON plc
Verified email at PRAHS.com
Title
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Cited by
Year
Internal standards in the quantitative determination of protein biopharmaceuticals using liquid chromatography coupled to mass spectrometry
KJ Bronsema, R Bischoff, NC van de Merbel
Journal of Chromatography B 893, 1-14, 2012
1722012
High-sensitivity LC-MS/MS quantification of peptides and proteins in complex biological samples: the impact of enzymatic digestion and internal standard selection on method …
KJ Bronsema, R Bischoff, NC van de Merbel
Analytical chemistry 85 (20), 9528-9535, 2013
1042013
A validated liquid chromatography–tandem mass spectrometry method for the quantitative determination of 4β-hydroxycholesterol in human plasma
NC van de Merbel, KJ Bronsema, MWJ van Hout, R Nilsson, H Sillén
Journal of pharmaceutical and biomedical analysis 55 (5), 1089-1095, 2011
572011
Analysis of biopharmaceutical proteins in biological matrices by LC-MS/MS I. Sample preparation
R Bischoff, KJ Bronsema, NC van de Merbel
TrAC Trends in Analytical Chemistry 48, 41-51, 2013
362013
High sustained antibody titers in patients with classic infantile Pompe disease following immunomodulation at start of enzyme replacement therapy
E Poelman, M Hoogeveen-Westerveld, MA Kroos-de Haan, ...
The Journal of Pediatrics 195, 236-243. e3, 2018
312018
Absolute quantification of the total and antidrug antibody-bound concentrations of recombinant human α-glucosidase in human plasma using protein G extraction and LC-MS/MS
KJ Bronsema, R Bischoff, WWMP Pijnappel, AT van der Ploeg, ...
Analytical chemistry 87 (8), 4394-4401, 2015
272015
A quantitative LC-MS/MS method for insulin-like growth factor 1 in human plasma
KJ Bronsema, F Klont, FB Schalk, R Bischoff, IP Kema, NC van de Merbel
Clinical Chemistry and Laboratory Medicine (CCLM) 56 (11), 1905-1912, 2018
232018
High-sensitivity quantitation of a Nanobody® in plasma by singlecartridge multidimensional SPE and ultra-performance LC–MS/MS
KJ Bronsema, R Bischoff, MP Bouche, K Mortier, NC van de Merbel
Bioanalysis 7 (1), 53-64, 2015
152015
Protein quantification using LC–MS: can it make a difference?
NC van de Merbel, KJ Bronsema, M Nemansky
Bioanalysis 4 (17), 2113-2116, 2012
142012
Sensitivity improvement of the LC–MS/MS quantification of carbidopa in human plasma and urine by derivatization with 2, 4-pentanedione
NC van de Merbel, KJ Bronsema, SH Gorman, R Bakhtiar
Journal of Chromatography B 1064, 62-67, 2017
72017
MS quantification of peptides and proteins in complex biological samples: the impact of enzymatic digestion and internal standard selection on method performance
KJ Bronsema, R Bischoff, NC van de Merbel, L High-sensitivity
Anal Chem 85 (20), 9528-35, 2013
52013
Monitoring of the deuterated and nondeuterated forms of levodopa and five metabolites in plasma and urine by LC–MS/MS
NC van de Merbel, KJ Bronsema, SH Gorman, R Bakhtiar
Bioanalysis 11 (04), 279-293, 2019
12019
Development, validation and application of a quantitative LC-MS/MS method for insulin-like growth factor-1 in human plasma.
KJ Bronsema, R Bischoff, J Schlaman, FB Schalk, IP Kema, ...
Enhancing the possibilities of LC-MS/MS for the absolute quantification of …, 2015
12015
Development, validation and application of a liquid chromatography–tandem mass spectrometry method for the activity and inhibition of DPP-4
KJ Bronsema, W Lambert, S Charmont, R Sangana, R Trigt, MA Valentin
Bioanalysis 14 (6), 369-378, 2022
2022
Antibody formation to enzyme replacement therapy in classic infantile Pompe disease: effects of immunomodulation in naïve patients
E Poelman, M Hoogeveen–Westerveld, M Kroos-de Haan, ...
Neuromuscular Disorders 27, S162, 2017
2017
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