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Douglas Gladue
Douglas Gladue
Senior Scientist, Agricultural Research Service at Plum Island Animal Disease Center
Geverifieerd e-mailadres voor usda.gov - Homepage
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African swine fever virus Georgia isolate harboring deletions of MGF360 and MGF505 genes is attenuated in swine and confers protection against challenge with virulent parental …
V O'Donnell, LG Holinka, DP Gladue, B Sanford, PW Krug, X Lu, J Arzt, ...
Journal of virology 89 (11), 6048-6056, 2015
2952015
Development of a highly effective African swine fever virus vaccine by deletion of the I177L gene results in sterile immunity against the current epidemic Eurasia strain
MV Borca, E Ramirez-Medina, E Silva, E Vuono, A Rai, S Pruitt, ...
Journal of virology 94 (7), 10.1128/jvi. 02017-19, 2020
2552020
DEP-domain-mediated regulation of GPCR signaling responses
DR Ballon, PL Flanary, DP Gladue, JB Konopka, HG Dohlman, J Thorner
Cell 126 (6), 1079-1093, 2006
2252006
Simultaneous Deletion of the 9GL and UK Genes from the African Swine Fever Virus Georgia 2007 Isolate Offers Increased Safety and Protection against …
V O'Donnell, GR Risatti, LG Holinka, PW Krug, J Carlson, ...
Journal of virology 91 (1), 10.1128/jvi. 01760-16, 2017
2062017
African Swine Fever Virus Georgia 2007 with a Deletion of Virulence-Associated Gene 9GL (B119L), when Administered at Low Doses, Leads to Virus Attenuation …
V O'Donnell, LG Holinka, PW Krug, DP Gladue, J Carlson, B Sanford, ...
Journal of virology 89 (16), 8556-8566, 2015
1762015
The progressive adaptation of a georgian isolate of African swine fever virus to vero cells leads to a gradual attenuation of virulence in swine corresponding to major …
PW Krug, LG Holinka, V O'Donnell, B Reese, B Sanford, ...
Journal of virology 89 (4), 2324-2332, 2015
1592015
African swine fever virus Georgia isolate harboring deletions of 9GL and MGF360/505 genes is highly attenuated in swine but does not confer protection against parental virus …
V O’Donnell, LG Holinka, B Sanford, PW Krug, J Carlson, JM Pacheco, ...
Virus research 221, 8-14, 2016
1352016
Positive selection of ORF1ab, ORF3a, and ORF8 genes drives the early evolutionary trends of SARS-CoV-2 during the 2020 COVID-19 pandemic
L Velazquez-Salinas, S Zarate, S Eberl, DP Gladue, I Novella, MV Borca
Frontiers in microbiology 11, 550674, 2020
1312020
Foot-and-mouth disease virus nonstructural protein 2C interacts with Beclin1, modulating virus replication
DP Gladue, V O'Donnell, R Baker-Branstetter, LG Holinka, JM Pacheco, ...
Journal of virology 86 (22), 12080-12090, 2012
1102012
ASFV-G-∆ I177L as an effective oral nasal vaccine against the Eurasia strain of Africa swine fever
MV Borca, E Ramirez-Medina, E Silva, E Vuono, A Rai, S Pruitt, ...
Viruses 13 (5), 765, 2021
912021
African swine fever virus vaccine candidate ASFV‐G‐ΔI177L efficiently protects European and native pig breeds against circulating Vietnamese field strain
XH Tran, TTP Le, QH Nguyen, TT Do, VD Nguyen, CG Gay, MV Borca, ...
Transboundary and Emerging Diseases 69 (4), e497-e504, 2022
862022
Deletion of CD2-like gene from the genome of African swine fever virus strain Georgia does not attenuate virulence in swine
MV Borca, V o’Donnell, LG Holinka, GR Risatti, E Ramirez-Medina, ...
Scientific reports 10 (1), 494, 2020
842020
Mechanisms of African swine fever virus pathogenesis and immune evasion inferred from gene expression changes in infected swine macrophages
JJ Zhu, P Ramanathan, EA Bishop, V O’Donnell, DP Gladue, MV Borca
PloS one 14 (11), e0223955, 2019
822019
Deletion of the thymidine kinase gene induces complete attenuation of the Georgia isolate of African swine fever virus
B Sanford, LG Holinka, V O'donnell, PW Krug, J Carlson, M Alfano, ...
Virus research 213, 165-171, 2016
822016
A cell culture-adapted vaccine virus against the current African swine fever virus pandemic strain
MV Borca, A Rai, E Ramirez-Medina, E Silva, L Velazquez-Salinas, ...
Journal of virology 95 (14), 10.1128/jvi. 00123-21, 2021
812021
Association of the host immune response with protection using a live attenuated African swine fever virus model
J Carlson, V O’Donnell, M Alfano, L Velazquez Salinas, LG Holinka, ...
Viruses 8 (10), 291, 2016
802016
Classical swine fever virus p7 protein is a viroporin involved in virulence in swine
DP Gladue, LG Holinka, E Largo, I Fernandez Sainz, C Carrillo, ...
Journal of virology 86 (12), 6778-6791, 2012
792012
CRISPR-Cas9, a tool to efficiently increase the development of recombinant African swine fever viruses
MV Borca, LG Holinka, KA Berggren, DP Gladue
Scientific reports 8 (1), 3154, 2018
782018
Deletion of the A137R gene from the pandemic strain of African swine fever virus attenuates the strain and offers protection against the virulent pandemic virus
DP Gladue, E Ramirez-Medina, E Vuono, E Silva, A Rai, S Pruitt, ...
Journal of virology 95 (21), 10.1128/jvi. 01139-21, 2021
732021
Foot-and-mouth disease virus modulates cellular vimentin for virus survival
DP Gladue, V O'donnell, R Baker-Branstetter, LG Holinka, JM Pacheco, ...
Journal of virology 87 (12), 6794-6803, 2013
672013
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