Khaled Abduljalil
Khaled Abduljalil
Sr Principal Scientist
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Anatomical, physiological and metabolic changes with gestational age during normal pregnancy
K Abduljalil, P Furness, TN Johnson, A Rostami-Hodjegan, H Soltani
Clinical pharmacokinetics 51 (6), 365-396, 2012
Does age affect gastric emptying time? A model‐based meta‐analysis of data from premature neonates through to adults
JJ Bonner, P Vajjah, K Abduljalil, M Jamei, A Rostami‐Hodjegan, ...
Biopharmaceutics & drug disposition 36 (4), 245-257, 2015
A pregnancy physiologically based pharmacokinetic (p‐PBPK) model for disposition of drugs metabolized by CYP1A2, CYP2D6 and CYP3A4
L Gaohua, K Abduljalil, M Jamei, TN Johnson, A Rostami‐Hodjegan
British journal of clinical pharmacology 74 (5), 873-885, 2012
A re-evaluation and validation of ontogeny functions for cytochrome P450 1A2 and 3A4 based on in vivo data
F Salem, TN Johnson, K Abduljalil, GT Tucker, A Rostami-Hodjegan
Clinical pharmacokinetics 53 (7), 625-636, 2014
Deciding on success criteria for predictability of pharmacokinetic parameters from in vitro studies: an analysis based on in vivo observations
K Abduljalil, T Cain, H Humphries, A Rostami-Hodjegan
Drug Metabolism and Disposition 42 (9), 1478-1484, 2014
Factors influencing pharmacokinetics of prophylactic posaconazole in patients undergoing allogeneic stem cell transplantation
V Kohl, C Muller, OA Cornely, K Abduljalil, U Fuhr, JJ Vehreschild, ...
Antimicrobial agents and chemotherapy 54 (1), 207-212, 2010
Application of a Physiologically Based Pharmacokinetic Model to Predict OATP1B1‐Related Variability in Pharmacodynamics of Rosuvastatin
RH Rose, S Neuhoff, K Abduljalil, M Chetty, A Rostami‐Hodjegan, ...
CPT: pharmacometrics & systems pharmacology 3 (7), 1-9, 2014
Changes in individual drug-independent system parameters during virtual paediatric pharmacokinetic trials: introducing time-varying physiology into a paediatric PBPK model
K Abduljalil, M Jamei, A Rostami-Hodjegan, TN Johnson
The AAPS journal 16 (3), 568-576, 2014
Assessment of Activity Levels for CYP2D6*1, CYP2D6*2, and CYP2D6*41 Genes by Population Pharmacokinetics of Dextromethorphan
K Abduljalil, D Frank, A Gaedigk, T Klaassen, D Tomalik‐Scharte, A Jetter, ...
Clinical Pharmacology & Therapeutics 88 (5), 643-651, 2010
Drug dosing in pregnant women: challenges and opportunities in using physiologically based pharmacokinetic modeling and simulations
AB Ke, R Greupink, K Abduljalil
CPT: pharmacometrics & systems pharmacology 7 (2), 103-110, 2018
Applications of linking PBPK and PD models to predict the impact of genotypic variability, formulation differences, differences in target binding capacity and target site drug …
M Chetty, RH Rose, K Abduljalil, N Patel, G Lu, T Cain, M Jamei, ...
Frontiers in pharmacology 5, 258, 2014
Physiologically-based pharmacokinetic (PBPK) models for assessing the kinetics of xenobiotics during pregnancy: achievements and shortcomings
G Lu, K Abduljalil, M Jamei, T N Johnson, H Soltani, A Rostami-Hodjegan
Current drug metabolism 13 (6), 695-720, 2012
Considering age variation when coining drugs as high versus low hepatic extraction ratio
F Salem, K Abduljalil, Y Kamiyama, A Rostami-Hodjegan
Drug Metabolism and Disposition 44 (7), 1099-1102, 2016
Preterm physiologically based pharmacokinetic model. Part II: applications of the model to predict drug pharmacokinetics in the preterm population
K Abduljalil, X Pan, A Pansari, M Jamei, TN Johnson
Clinical Pharmacokinetics 59 (4), 501-518, 2020
Fetal physiologically based pharmacokinetic models: systems information on the growth and composition of fetal organs
K Abduljalil, M Jamei, TN Johnson
Clinical Pharmacokinetics 58 (2), 235-262, 2019
Fetal physiologically-based pharmacokinetic models: systems information on fetal biometry and gross composition
K Abduljalil, TN Johnson, A Rostami-Hodjegan
Clinical pharmacokinetics 57 (9), 1149-1171, 2018
A preterm physiologically based pharmacokinetic model. Part I: physiological parameters and model building
K Abduljalil, X Pan, A Pansari, M Jamei, TN Johnson
Clinical Pharmacokinetics 59 (4), 485-500, 2020
Drug dosing during pregnancy—opportunities for physiologically based pharmacokinetic models
K Abduljalil, RKS Badhan
Journal of pharmacokinetics and pharmacodynamics 47 (4), 319-340, 2020
Prediction of maternal pharmacokinetics using physiologically based pharmacokinetic models: assessing the impact of the longitudinal changes in the activity of CYP1A2, CYP2D6 …
K Abduljalil, A Pansari, M Jamei
Journal of Pharmacokinetics and Pharmacodynamics 47 (4), 361-383, 2020
More power to OATP1B1: an evaluation of sample size in pharmacogenetic studies using a rosuvastatin PBPK model for intestinal, hepatic, and renal transporter‐mediated clearances
A Emami Riedmaier, H Burt, K Abduljalil, S Neuhoff
The Journal of Clinical Pharmacology 56, S132-S142, 2016
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