| The oncometabolite 2‐hydroxyglutarate inhibits histone lysine demethylases R Chowdhury, KK Yeoh, YM Tian, L Hillringhaus, EA Bagg, NR Rose, ... EMBO reports 12 (5), 463-469, 2011 | 1104 | 2011 |
| A safe lithium mimetic for bipolar disorder N Singh, AC Halliday, JM Thomas, OV Kuznetsova, R Baldwin, ... Nature communications 4 (1), 1332, 2013 | 295 | 2013 |
| Selective inhibitors of the JMJD2 histone demethylases: combined nondenaturing mass spectrometric screening and crystallographic approaches NR Rose, ECY Woon, GL Kingham, ONF King, J Mecinovic, IJ Clifton, ... Journal of medicinal chemistry 53 (4), 1810-1818, 2010 | 179 | 2010 |
| Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases NR Rose, ECY Woon, A Tumber, LJ Walport, R Chowdhury, XS Li, ... Journal of medicinal chemistry 55 (14), 6639-6643, 2012 | 158 | 2012 |
| N6-Methyladenosine: a conformational marker that regulates the substrate specificity of human demethylases FTO and ALKBH5 S Zou, JDW Toh, KHQ Wong, YG Gao, W Hong, ECY Woon Scientific reports 6 (1), 25677, 2016 | 151 | 2016 |
| Inhibition of histone demethylases by 4-carboxy-2, 2′-bipyridyl compounds KH Chang, ONF King, A Tumber, ECY Woon, TD Heightman, ... ChemMedChem 6 (5), 759, 2011 | 107 | 2011 |
| A strategy based on nucleotide specificity leads to a subfamily-selective and cell-active inhibitor of N 6-methyladenosine demethylase FTO JDW Toh, L Sun, LZM Lau, J Tan, JJA Low, CWQ Tang, EJY Cheong, ... Chemical science 6 (1), 112-122, 2015 | 100 | 2015 |
| Dynamic combinatorial chemistry employing boronic acids/boronate esters leads to potent oxygenase inhibitors M Demetriades, IKH Leung, R Chowdhury, MC Chan, MA McDonough, ... Angewandte Chemie International Edition 51 (27), 6672-6675, 2012 | 96 | 2012 |
| Doxorubicin-loaded cell-derived nanovesicles: An alternative targeted approach for anti-tumor therapy WJ Goh, CK Lee, S Zou, ECY Woon, B Czarny, G Pastorin International journal of nanomedicine, 2759-2767, 2017 | 95 | 2017 |
| Linking of 2‐oxoglutarate and substrate binding sites enables potent and highly selective inhibition of JmjC histone demethylases ECY Woon, A Tumber, A Kawamura, L Hillringhaus, W Ge, NR Rose, ... Angewandte Chemie 124 (7), 1663-1666, 2012 | 83 | 2012 |
| Poly (ADP-ribose) polymerase inhibition-where now? ECY Woon, MD Threadgill Current medicinal chemistry 12 (20), 2373-2392, 2005 | 80 | 2005 |
| 5-Nitroisocoumarins from tandem Castro–Stephens coupling—6-endo-dig cyclisation of 2-iodo-3-nitrobenzoic acid and arylethynes and ring-closure of methyl 2-alkynyl-3 … ECY Woon, A Dhami, MF Mahon, MD Threadgill Tetrahedron 62 (20), 4829-4837, 2006 | 70 | 2006 |
| Dynamic combinatorial mass spectrometry leads to inhibitors of a 2-oxoglutarate-dependent nucleic acid demethylase ECY Woon, M Demetriades, EAL Bagg, WS Aik, SM Krylova, JHY Ma, ... Journal of medicinal chemistry 55 (5), 2173-2184, 2012 | 60 | 2012 |
| 5-Benzamidoisoquinolin-1-ones and 5-(ω-carboxyalkyl) isoquinolin-1-ones as isoform-selective inhibitors of poly (ADP-ribose) polymerase 2 (PARP-2) PT Sunderland, ECY Woon, A Dhami, AB Bergin, MF Mahon, PJ Wood, ... Journal of medicinal chemistry 54 (7), 2049-2059, 2011 | 60 | 2011 |
| Observations on the deprotection of pinanediol and pinacol boronate esters via fluorinated intermediates SR Inglis, ECY Woon, AL Thompson, CJ Schofield The Journal of Organic Chemistry 75 (2), 468-471, 2010 | 55 | 2010 |
| Structure-Guided Design of Cell Wall Biosynthesis Inhibitors That Overcome β-Lactam Resistance in Staphylococcus aureus (MRSA) C Contreras-Martel, A Amoroso, ECY Woon, A Zervosen, S Inglis, ... ACS chemical biology 6 (9), 943-951, 2011 | 51 | 2011 |
| Synthesis and Evaluation of 3-(Dihydroxyboryl)benzoic Acids as d,d-Carboxypeptidase R39 Inhibitors SR Inglis, A Zervosen, ECY Woon, T Gerards, N Teller, DS Fischer, ... Journal of medicinal chemistry 52 (19), 6097-6106, 2009 | 49 | 2009 |
| Hepatic FTO expression is increased in NASH and its silencing attenuates palmitic acid-induced lipotoxicity A Lim, J Zhou, RA Sinha, BK Singh, S Ghosh, KH Lim, PKH Chow, ... Biochemical and biophysical research communications 479 (3), 476-481, 2016 | 42 | 2016 |
| Exploration of the nicotinamide-binding site of the tankyrases, identifying 3-arylisoquinolin-1-ones as potent and selective inhibitors in vitro HA Paine, A Nathubhai, ECY Woon, PT Sunderland, PJ Wood, MF Mahon, ... Bioorganic & Medicinal Chemistry 23 (17), 5891-5908, 2015 | 33 | 2015 |
| Structure guided development of potent reversibly binding penicillin binding protein inhibitors ECY Woon, A Zervosen, E Sauvage, KJ Simmons, M Zivec, SR Inglis, ... ACS medicinal chemistry letters 2 (3), 219-223, 2011 | 33 | 2011 |
