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A. S. Lewin
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Ribozyme rescue of photoreceptor cells in a transgenic rat model of autosomal dominant retinitis pigmentosa
AS Lewin, KA Drenser, WW Hauswirth, S Nishikawa, D Yasumura, ...
Nature medicine 4 (8), 967-971, 1998
5151998
High-efficiency transduction of the mouse retina by tyrosine-mutant AAV serotype vectors
H Petrs-Silva, A Dinculescu, Q Li, SH Min, V Chiodo, JJ Pang, L Zhong, ...
Molecular therapy 17 (3), 463-471, 2009
4872009
Dysregulated autophagy in the RPE is associated with increased susceptibility to oxidative stress and AMD
SK Mitter, C Song, X Qi, H Mao, H Rao, D Akin, A Lewin, M Grant, ...
Autophagy 10 (11), 1989-2005, 2014
4472014
A comprehensive review of retinal gene therapy
SE Boye, SL Boye, AS Lewin, WW Hauswirth
Molecular therapy 21 (3), 509-519, 2013
3382013
Intrastriatal rAAV-mediated delivery of anti-huntingtin shRNAs induces partial reversal of disease progression in R6/1 Huntington's disease transgenic mice
E Rodriguez-Lebron, EM Denovan-Wright, K Nash, AS Lewin, RJ Mandel
Molecular therapy 12 (4), 618-633, 2005
3262005
Gene therapy rescues photoreceptor blindness in dogs and paves the way for treating human X-linked retinitis pigmentosa
WA Beltran, AV Cideciyan, AS Lewin, S Iwabe, H Khanna, A Sumaroka, ...
Proceedings of the National Academy of Sciences 109 (6), 2132-2137, 2012
3152012
Rescue of a mitochondrial deficiency causing Leber hereditary optic neuropathy
J Guy, X Qi, F Pallotti, EA Schon, G Manfredi, V Carelli, A Martinuzzi, ...
Annals of Neurology: Official Journal of the American Neurological …, 2002
3052002
Novel properties of tyrosine-mutant AAV2 vectors in the mouse retina
H Petrs-Silva, A Dinculescu, Q Li, WT Deng, J Pang, SH Min, V Chiodo, ...
Molecular Therapy 19 (2), 293-301, 2011
3042011
Restoration of visual function in P23H rhodopsin transgenic rats by gene delivery of BiP/Grp78
MS Gorbatyuk, T Knox, MM LaVail, OS Gorbatyuk, SM Noorwez, ...
Proceedings of the National Academy of Sciences 107 (13), 5961-5966, 2010
2982010
SOD2 knockdown mouse model of early AMD
V Justilien, JJ Pang, K Renganathan, X Zhan, JW Crabb, SR Kim, ...
Investigative ophthalmology & visual science 48 (10), 4407-4420, 2007
2732007
Ribozyme rescue of photoreceptor cells in P23H transgenic rats: long-term survival and late-stage therapy
MM LaVail, D Yasumura, MT Matthes, KA Drenser, JG Flannery, AS Lewin, ...
Proceedings of the National Academy of Sciences 97 (21), 11488-11493, 2000
2642000
In vivo RNAi-mediated α-synuclein silencing induces nigrostriatal degeneration
OS Gorbatyuk, S Li, K Nash, M Gorbatyuk, AS Lewin, LF Sullivan, ...
Molecular Therapy 18 (8), 1450-1457, 2010
2342010
[48] Production and purification of recombinant adeno-associated virus
WW Hauswirth, AS Lewin, S Zolotukhin, N Muzyczka
Methods in enzymology 316, 743-761, 2000
2062000
Ribozyme gene therapy: applications for molecular medicine
AS Lewin, WW Hauswirth
Trends in molecular medicine 7 (5), 221-228, 2001
2012001
Glucose regulated protein 78 diminishes α-synuclein neurotoxicity in a rat model of Parkinson disease
MS Gorbatyuk, A Shabashvili, W Chen, C Meyers, LF Sullivan, M Salganik, ...
Molecular Therapy 20 (7), 1327-1337, 2012
1972012
ACE2 and Ang-(1-7) confer protection against development of diabetic retinopathy
A Verma, Z Shan, B Lei, L Yuan, X Liu, T Nakagawa, MB Grant, AS Lewin, ...
Molecular therapy 20 (1), 28-36, 2012
1972012
Gene delivery to mitochondria by targeting modified adenoassociated virus suppresses Leber’s hereditary optic neuropathy in a mouse model
H Yu, RD Koilkonda, TH Chou, V Porciatti, SS Ozdemir, V Chiodo, ...
Proceedings of the National Academy of Sciences 109 (20), E1238-E1247, 2012
1812012
Mitochondrial oxidative stress in the retinal pigment epithelium (RPE) led to metabolic dysfunction in both the RPE and retinal photoreceptors
EE Brown, AJ DeWeerd, CJ Ildefonso, AS Lewin, JD Ash
Redox biology 24, 101201, 2019
1772019
Mitochondrial protein nitration primes neurodegeneration in experimental autoimmune encephalomyelitis
X Qi, AS Lewin, L Sun, WW Hauswirth, J Guy
Journal of Biological Chemistry 281 (42), 31950-31962, 2006
1682006
Citrate Synthase Encoded by the CIT2 Gene of Saccharomyces cerevisiae Is Peroxisomal
AS Lewin, V Hines, GM Small
Molecular and Cellular Biology 10 (4), 1399-1405, 1990
1501990
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Artikelen 1–20