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Gerbrand J. van der Heden van Noort
Gerbrand J. van der Heden van Noort
Associate professor - Leiden University Medical Centre, Leiden (NL)
Geverifieerd e-mailadres voor lumc.nl
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Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity
D Shin, R Mukherjee, D Grewe, D Bojkova, K Baek, A Bhattacharya, ...
Nature 587 (7835), 657-662, 2020
9072020
Mechanism and inhibition of the papain‐like protease, PLpro, of SARS‐CoV‐2
T Klemm, G Ebert, DJ Calleja, CC Allison, LW Richardson, JP Bernardini, ...
The EMBO journal 39 (18), e106275, 2020
3752020
Recognition of Lys48-Linked Di-ubiquitin and Deubiquitinating Activities of the SARS Coronavirus Papain-like Protease
CDL Miklós Békés, Gerbrand J. van der Heden van Noort, Reggy Ekkebus, Huib ...
Molecular Cell 62 (4), 572-585, 2016
1372016
Non-hydrolyzable Diubiquitin Probes Reveal Linkage- Specific Reactivity of Deubiquitylating Enzymes Mediated by S2 Pockets’
D Flierman, GJ van der Heden van Noort, R Ekkebus, PP Geurink, ...
Cell Chemical Biology 23 (4), 472-482, 2016
1072016
An RNA virus hijacks an incognito function of a DNA repair enzyme
R Virgen-Slane, JM Rozovics, KD Fitzgerald, T Ngo, W Chou, ...
Proceedings of the National Academy of Sciences 109 (36), 14634-14639, 2012
1022012
Synthesis of mono-ADP-ribosylated oligopeptides using ribosylated amino acid building blocks
GJ van der Heden van Noort, MG van der Horst, HS Overkleeft, ...
Journal of the American Chemical Society 132 (14), 5236-5240, 2010
652010
Stereoselective ribosylation of amino acids
HAV Kistemaker, GJ van der Heden van Noort, HS Overkleeft, ...
Organic letters 15 (9), 2306-2309, 2013
512013
Famotidine inhibits toll-like receptor 3-mediated inflammatory signaling in SARS-CoV-2 infection
R Mukherjee, A Bhattacharya, D Bojkova, AR Mehdipour, D Shin, ...
Journal of Biological Chemistry 297 (2), 2021
502021
Synthesis of 2-alkoxy-8-hydroxyadenylpeptides: Towards synthetic epitope-based vaccines
JJ Weterings, S Khan, GJ van der Heden, JW Drijfhout, CJM Melief, ...
Bioorganic & medicinal chemistry letters 16 (12), 3258-3261, 2006
392006
Modification of picornavirus genomic RNA using ‘click’chemistry shows that unlinking of the VPg peptide is dispensable for translation and replication of the incoming viral RNA
MA Langereis, Q Feng, FHT Nelissen, R Virgen-Slane, ...
Nucleic acids research 42 (4), 2473-2482, 2014
382014
Ribosylation of adenosine: an orthogonally protected building block for the synthesis of ADP-ribosyl oligomers
GJ van der Heden van Noort, HS Overkleeft, GA van der Marel, ...
Organic Letters 13 (11), 2920-2923, 2011
312011
2-Azidoalkoxy-7-hydro-8-oxoadenine derivatives as TLR7 agonists inducing dendritic cell maturation
JJ Weterings, S Khan, CJM Melief, HS Overkleeft, SH van der Burg, ...
Bioorganic & medicinal chemistry letters 19 (8), 2249-2251, 2009
312009
A general approach towards triazole‐linked adenosine diphosphate ribosylated peptides and proteins
Q Liu, HAV Kistemaker, S Bhogaraju, I Dikic, HS Overkleeft, ...
Angewandte Chemie International Edition 57 (6), 1659-1662, 2018
302018
DNA-triggered dye transfer on a quantum dot
J Michaelis, GJ van der Heden van Noort, O Seitz
Bioconjugate Chemistry 25 (1), 18-23, 2014
302014
A Versatile One-Pot Procedure to Phosphate Monoesters and Pyrophosphates Using Di(p-methoxybenzyl)-N,N-diisopropylphosphoramidite
GJ van der Heden van Noort, CP Verhagen, MG van der Horst, ...
Organic Letters 10 (20), 4461-4464, 2008
282008
Bacterial OTU deubiquitinases regulate substrate ubiquitination upon Legionella infection
D Shin, A Bhattacharya, YL Cheng, MC Alonso, AR Mehdipour, ...
Elife 9, e58277, 2020
272020
Linkage-specific ubiquitin chain formation depends on a lysine hydrocarbon ruler
J Liwocha, DT Krist, GJ van der Heden van Noort, FM Hansen, VH Truong, ...
Nature chemical biology 17 (3), 272-279, 2021
262021
Generation of the UFM1 Toolkit for Profiling UFM1‐Specific Proteases and Ligases
KF Witting, GJ van der Heden van Noort, C Kofoed, C Talavera Ormeńo, ...
Angewandte Chemie 130 (43), 14360-14364, 2018
262018
Synthesis of nucleotidylated poliovirus VPg proteins
GJ van der Heden van Noort, HS Overkleeft, GA van der Marel, ...
The Journal of Organic Chemistry 75 (16), 5733-5736, 2010
252010
Synthesis of poly-ubiquitin chains using a bifunctional ubiquitin monomer
GJ van der Heden van Noort, R Kooij, PR Elliott, D Komander, H Ovaa
Organic letters 19 (24), 6490-6493, 2017
232017
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