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Ádám I. Horváth
Ádám I. Horváth
Geverifieerd e-mailadres voor ttk.elte.hu
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Single residue variation in skeletal muscle myosin enables direct and selective drug targeting for spasticity and muscle stiffness
M Gyimesi, ÁI Horváth, D Túrós, SK Suthar, M Pénzes, C Kurdi, L Canon, ...
Cell 183 (2), 335-346. e13, 2020
282020
Effect of allosteric inhibition of non-muscle myosin 2 on its intracellular diffusion
ÁI Horváth, M Gyimesi, BH Várkuti, M Képiró, G Szegvári, I Lőrincz, ...
Scientific Reports 10 (1), 13341, 2020
92020
Investigation of the relationships between material properties and processing parameters of boron micro-alloyed quenched and tempered steels
J Loerinczi, G Kralik, M Kovacs, A Horvath
Materials Science Forum 414, 2003
92003
Titin activates myosin filaments in skeletal muscle by switching from an extensible spring to a mechanical rectifier
C Squarci, P Bianco, M Reconditi, I Pertici, M Caremani, T Narayanan, ...
Proceedings of the National Academy of Sciences 120 (9), e2219346120, 2023
72023
The New-Generation Muscle Relaxant MPH-220 Dissolves Spasticity in Muscles After Cns Injury-a Promising Drug to Address Post-Stroke Spasticity
M Gyimesi, AI Horvath, D Túrós, G Hegyi, SK Suthar, M Kovacs, ...
Biophysical Journal 118 (3), 434a, 2020
12020
Pharmaceutically effective compounds inhibiting selectively the myosin 2 isoforms
A Málnási-Csizmadia, M Gyimesi, A Szabó, P Hári, SS Kumar, M Kovács, ...
US Patent 11,845,758, 2023
2023
Pharmaceutically effective compounds inhibiting selectively the myosin 2 isoforms
A Málnási-Csizmadia, M Gyimesi, A Szabó, P Hári, SS Kumar, M Kovács, ...
US Patent 11,746,112, 2023
2023
Titin function in the active sarcomere studied in frog muscle fibers upon inhibition of myosin motors by para-nitro-blebbistatin
C Squarci, P Bianco, M Reconditi, I Pertici, M Caremani, T Narayanan, ...
Biophysical Journal 122 (3), 29a, 2023
2023
Regulation of APD and force by Na+/Ca2+ exchanger in hiPSC-cardiomyocytes
D Ismaili, K Gurr, A Horvath, L Yuan, MD Lemoine, C Schulz, J Sani, ...
Europace 24 (Supplement_1), euac053. 625, 2022
2022
The role of NM2 rearrangement during cytokinesis
AI Horvath, M Gyimesi, M Kepiro, B Varkuti, A Malnasi-Csizmadia
Biophysical Journal 121 (3), 259a-260a, 2022
2022
Application of neural-network-based deep-learning analysis to reveal changes of the movement parameters in rat neuromuscular disorder models
M Winternitz, M Gyimesi, AI Horvath, M Penzes, A Malnasi-Csizmadia
Biophysical Journal 121 (3), 258a-259a, 2022
2022
Passive and active mechanical properties of titin studied in intact frog muscle fibers upon inhibition of myosin motors by para-nitro-blebbistatin
C Squarci, P Bianco, M Reconditi, I Pertici, M Caremani, T Narayanan, ...
Biophysical Journal 121 (3), 515a, 2022
2022
First-in-class drug candidate (MPH-220) efficiently improves spastic gait disorders by selective inhibition of fast skeletal muscle myosin-2
M Gyimesi, AI Horvath, D Turos, SK Suthar, M Penzes, L Canon, C Kikuti, ...
Biophysical Journal 121 (3), 291a, 2022
2022
Culture conditions effect properties of the Na+/K+-ATPase pump current in hiPSC cardiomyocytes
D Ismaili, K Gurr, A Horvath, A Hansen, T Eschenhagen, T Christ
EP Europace 23 (Supplement_3), euab116. 577, 2021
2021
Abstract P221: First-In-Class Anti-Spastic Drug Candidate (MPH-220) Efficiently Relaxes Spastic Muscles and Improves Motor Functions in Gait Disorder in Preclinical Studies
M Gyimesi, A Horvath, D Turos, M Penzes, C Kurdi, M Kovacs, ...
Stroke 52 (Suppl_1), AP221-AP221, 2021
2021
First-In-Class Anti-Spastic Drug Candidate (MPH-220) Efficiently Relaxes Spastic Muscles and Improves Motor Functions in Gait Disorder in Preclinical Studies.
M Gyimesi, A Horvath, D Turos, M Penzes, C Kurdi, M Kovacs, ...
STROKE 52, 2021
2021
NEW-GENERATION ANTI-SPASTIC DRUG CANDIDATE (MPH-220) IMPROVES MOTOR FUNCTIONS OF SPASTIC RATS WITH BRAIN DAMAGE
M Gyimesi, A Horvath, D Turos, M Penzes, C Kurdi, A Szabo, M Kovacs, ...
INTERNATIONAL JOURNAL OF STROKE 15 (1_ SUPPL), 266-266, 2020
2020
3D Movement Analysis using Deep Learning Algorithms Reveals Alterations in Motor Functions After Neurological Injuries in RAT Spasticity Model
D Túrós, AI Horvath, M Gyimesi, A Malnasi-Csizmadia
Biophysical Journal 118 (3), 461a, 2020
2020
CRISPR/Cas9 genome editing repairs a novel ACTN2 mutation and prevents the disease phenotype in human iPSC-derived cardiomyocytes and engineered heart tissue
M Prondzynski, M Lemoine, A Horvath, E Krämer, ATL Zech, S Laufer, ...
Journal of Molecular and Cellular Cardiology 120, 7, 2018
2018
Properties of the sodium-calcium exchanger and the Na+/K+-ATPase in human induced pluripotent stem cell-derived cardiomyocytes
A Horvath, K Gurr, D Ismaili, I Mannhardt, B Ulmer, A Hansen, A Varro, ...
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY 109, 20-20, 2017
2017
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