Follow
Michael G Kharas
Title
Cited by
Cited by
Year
The N6-methyladenosine (m6A)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells
LP Vu, BF Pickering, Y Cheng, S Zaccara, D Nguyen, G Minuesa, T Chou, ...
Nature medicine 23 (11), 1369-1376, 2017
10122017
The Lin28/let-7 axis regulates glucose metabolism
H Zhu, N Shyh-Chang, AV Segrè, G Shinoda, SP Shah, WS Einhorn, ...
Cell 147 (1), 81-94, 2011
9732011
Efficacy of TG101348, a selective JAK2 inhibitor, in treatment of a murine model of JAK2V617F-induced polycythemia vera
G Wernig, MG Kharas, R Okabe, SA Moore, DS Leeman, DE Cullen, ...
Cancer cell 13 (4), 311-320, 2008
4472008
Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia
MG Kharas, CJ Lengner, F Al-Shahrour, L Bullinger, B Ball, S Zaidi, ...
Nature medicine 16 (8), 903-908, 2010
4072010
Physiological Jak2V617F expression causes a lethal myeloproliferative neoplasm with differential effects on hematopoietic stem and progenitor cells
A Mullally, SW Lane, B Ball, C Megerdichian, R Okabe, F Al-Shahrour, ...
Cancer cell 17 (6), 584-596, 2010
4062010
PI3K inhibition results in enhanced estrogen receptor function and dependence in hormone receptor–positive breast cancer
A Bosch, Z Li, A Bergamaschi, H Ellis, E Toska, A Prat, JJ Tao, DE Spratt, ...
Science translational medicine 7 (283), 283ra51-283ra51, 2015
3392015
Constitutively active AKT depletes hematopoietic stem cells and induces leukemia in mice
MG Kharas, R Okabe, JJ Ganis, M Gozo, T Khandan, M Paktinat, ...
Blood, The Journal of the American Society of Hematology 115 (7), 1406-1415, 2010
3312010
ABL Oncogenes and Phosphoinositide 3-Kinase: Mechanism of Activation and Downstream Effectors
MG Kharas, DA Fruman
Cancer research 65 (6), 2047-2053, 2005
2152005
Hedgehog signaling is dispensable for adult murine hematopoietic stem cell function and hematopoiesis
I Hofmann, EH Stover, DE Cullen, J Mao, KJ Morgan, BH Lee, MG Kharas, ...
Cell stem cell 4 (6), 559-567, 2009
2142009
Ablation of PI3K blocks BCR-ABL leukemogenesis in mice, and a dual PI3K/mTOR inhibitor prevents expansion of human BCR-ABL+ leukemia cells
MG Kharas, MR Janes, VM Scarfone, MB Lilly, ZA Knight, KM Shokat, ...
The Journal of clinical investigation 118 (9), 3038-3050, 2008
1882008
In Vivo RNAi screening identifies a leukemia-specific dependence on integrin beta 3 signaling
PG Miller, F Al-Shahrour, KA Hartwell, LP Chu, M Järås, RV Puram, ...
Cancer cell 24 (1), 45-58, 2013
1782013
Optimal B-cell proliferation requires phosphoinositide 3-kinase–dependent inactivation of FOXO transcription factors
I Yusuf, X Zhu, MG Kharas, J Chen, DA Fruman
Blood 104 (3), 784-787, 2004
1672004
Musashi-2 controls cell fate, lineage bias, and TGF-β signaling in HSCs
SM Park, RP Deering, Y Lu, P Tivnan, S Lianoglou, F Al-Shahrour, ...
Journal of Experimental Medicine 211 (1), 71-87, 2014
1612014
Stage-specific human induced pluripotent stem cells map the progression of myeloid transformation to transplantable leukemia
AG Kotini, CJ Chang, A Chow, H Yuan, TC Ho, T Wang, S Vora, ...
Cell stem cell 20 (3), 315-328. e7, 2017
1402017
Transformation of the intestinal epithelium by the MSI2 RNA-binding protein
S Wang, N Li, M Yousefi, A Nakauka-Ddamba, F Li, K Parada, S Rao, ...
Nature communications 6 (1), 6517, 2015
1392015
m6A RNA methylation maintains hematopoietic stem cell identity and symmetric commitment
Y Cheng, H Luo, F Izzo, BF Pickering, D Nguyen, R Myers, A Schurer, ...
Cell reports 28 (7), 1703-1716. e6, 2019
1352019
The Biology of m6A RNA Methylation in Normal and Malignant Hematopoiesis
LP Vu, Y Cheng, MG Kharas
Cancer discovery 9 (1), 25-33, 2019
1292019
N6-Methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation
Y Cheng, W Xie, BF Pickering, KL Chu, AM Savino, X Yang, H Luo, ...
Cancer cell 39 (7), 958-972. e8, 2021
1202021
Small-molecule targeting of MUSASHI RNA-binding activity in acute myeloid leukemia
G Minuesa, SK Albanese, W Xie, Y Kazansky, D Worroll, A Chow, ...
Nature communications 10 (1), 2691, 2019
1162019
Musashi2 sustains the mixed-lineage leukemia–driven stem cell regulatory program
SM Park, M Gönen, L Vu, G Minuesa, P Tivnan, TS Barlowe, J Taggart, ...
The Journal of clinical investigation 125 (3), 1286-1298, 2015
1092015
The system can't perform the operation now. Try again later.
Articles 1–20