| Human apoE isoforms differentially regulate brain amyloid-β peptide clearance JM Castellano, J Kim, FR Stewart, H Jiang, RB DeMattos, BW Patterson, ... Science translational medicine 3 (89), 89ra57-89ra57, 2011 | 1383 | 2011 |
| Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice SA Villeda, KE Plambeck, J Middeldorp, JM Castellano, KI Mosher, J Luo, ... Nature medicine 20 (6), 659-663, 2014 | 1096 | 2014 |
| Apolipoprotein E in Alzheimer's disease and other neurological disorders PB Verghese, JM Castellano, DM Holtzman The Lancet Neurology 10 (3), 241-252, 2011 | 1009 | 2011 |
| ApoE influences amyloid-β (Aβ) clearance despite minimal apoE/Aβ association in physiological conditions PB Verghese, JM Castellano, K Garai, Y Wang, H Jiang, A Shah, G Bu, ... Proceedings of the National Academy of Sciences 110 (19), E1807-E1816, 2013 | 611 | 2013 |
| Aging-induced type I interferon response at the choroid plexus negatively affects brain function K Baruch, A Deczkowska, E David, JM Castellano, O Miller, A Kertser, ... Science 346 (6205), 89-93, 2014 | 570 | 2014 |
| Human umbilical cord plasma proteins revitalize hippocampal function in aged mice JM Castellano, KI Mosher, RJ Abbey, AA McBride, ML James, D Berdnik, ... Nature 544 (7651), 488-492, 2017 | 407 | 2017 |
| Traumatic brain injury imaging in the second near-infrared window with a molecular fluorophore X Zhang, H Wang, AL Antaris, L Li, S Diao, R Ma, A Nguyen, G Hong, ... Advanced materials (Deerfield Beach, Fla.) 28 (32), 6872, 2016 | 325 | 2016 |
| Overexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular Aβ clearance J Kim, JM Castellano, H Jiang, JM Basak, M Parsadanian, V Pham, ... Neuron 64 (5), 632-644, 2009 | 277 | 2009 |
| Low-density lipoprotein receptor overexpression enhances the rate of brain-to-blood Aβ clearance in a mouse model of β-amyloidosis JM Castellano, R Deane, AJ Gottesdiener, PB Verghese, FR Stewart, ... Proceedings of the National Academy of Sciences 109 (38), 15502-15507, 2012 | 165 | 2012 |
| Long-term cognitive impairments and pathological alterations in a mouse model of repetitive mild traumatic brain injury J Luo, A Nguyen, S Villeda, H Zhang, Z Ding, D Lindsey, G Bieri, ... Frontiers in neurology 5, 12, 2014 | 155 | 2014 |
| CalFluors: a universal motif for fluorogenic azide probes across the visible spectrum P Shieh, VT Dien, BJ Beahm, JM Castellano, T Wyss-Coray, CR Bertozzi Journal of the American Chemical Society 137 (22), 7145-7151, 2015 | 153 | 2015 |
| In vivo measurement of apolipoprotein E from the brain interstitial fluid using microdialysis JD Ulrich, JM Burchett, JL Restivo, DR Schuler, PB Verghese, TE Mahan, ... Molecular neurodegeneration 8, 1-7, 2013 | 132 | 2013 |
| Microglial complement receptor 3 regulates brain Aβ levels through secreted proteolytic activity E Czirr, NA Castello, KI Mosher, JM Castellano, IV Hinkson, KM Lucin, ... Journal of Experimental Medicine 214 (4), 1081-1092, 2017 | 101 | 2017 |
| Effects of the absence of apolipoprotein e on lipoproteins, neurocognitive function, and retinal function ACY Mak, CR Pullinger, LF Tang, JS Wong, RC Deo, JM Schwarz, ... JAMA neurology 71 (10), 1228-1236, 2014 | 97 | 2014 |
| Blood-borne revitalization of the aged brain JM Castellano, ED Kirby, T Wyss-Coray JAMA neurology 72 (10), 1191-1194, 2015 | 92 | 2015 |
| Eosinophils regulate adipose tissue inflammation and sustain physical and immunological fitness in old age D Brigger, C Riether, R van Brummelen, KI Mosher, A Shiu, Z Ding, ... Nature metabolism 2 (8), 688-702, 2020 | 79 | 2020 |
| Blood-based therapies to combat aging JM Castellano Gerontology 65 (1), 84-89, 2019 | 40 | 2019 |
| In vivo assessment of behavioral recovery and circulatory exchange in the peritoneal parabiosis model JM Castellano, M Palner, SB Li, GM Freeman Jr, A Nguyen, B Shen, ... Scientific reports 6 (1), 29015, 2016 | 34 | 2016 |
| Methods and compositions for treating aging-associated conditions A Wyss-Coray, SA Villeda, JM Castellano, J Middeldorp, MS Angst, J Luo US Patent 10,688,130, 2020 | 28 | 2020 |
| APOE4 confers transcriptomic and functional alterations to primary mouse microglia SI Machlovi, SM Neuner, BM Hemmer, R Khan, Y Liu, M Huang, JD Zhu, ... Neurobiology of disease 164, 105615, 2022 | 26 | 2022 |
