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Patrick van Berkel
Patrick van Berkel
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Geverifieerd e-mailadres voor adctherapeutics.com
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Large scale production of recombinant human lactoferrin in the milk of transgenic cows
PHC Van Berkel, MM Welling, M Geerts, HA van Veen, B Ravensbergen, ...
Nature biotechnology 20 (5), 484-487, 2002
4232002
Efficient generation of stable bispecific IgG1 by controlled Fab-arm exchange
AF Labrijn, JI Meesters, BECG de Goeij, ETJ van den Bremer, J Neijssen, ...
Proceedings of the National Academy of Sciences 110 (13), 5145-5150, 2013
3962013
Human lactoferrin and peptides derived from its N terminus are highly effective against infections with antibiotic-resistant bacteria
PH Nibbering, E Ravensbergen, MM Welling, LA Van Berkel, ...
Infection and Immunity 69 (3), 1469-1476, 2001
3222001
Structure and biological actions of lactoferrin
JH Nuijens, PHC van Berkel, FL Schanbacher
Journal of Mammary Gland Biology and Neoplasia 1, 285-295, 1996
2671996
Antibody fucosylation differentially impacts cytotoxicity mediated by NK and PMN effector cells
M Peipp, JJ Lammerts van Bueren, T Schneider-Merck, WWK Bleeker, ...
Blood, The Journal of the American Society of Hematology 112 (6), 2390-2399, 2008
2612008
Human IgG2 antibodies against epidermal growth factor receptor effectively trigger antibody-dependent cellular cytotoxicity but, in contrast to IgG1, only by cells of myeloid …
T Schneider-Merck, JJ Lammerts van Bueren, S Berger, K Rossen, ...
The journal of immunology 184 (1), 512-520, 2010
2582010
High‐level expression of recombinant IgG in the human cell line PER. C6
D Jones, N Kroos, R Anema, B Van Montfort, A Vooys, S Kraats, E Helm, ...
Biotechnology progress 19 (1), 163-168, 2003
2552003
Modulation of antibody galactosylation through feeding of uridine, manganese chloride, and galactose
MJ Gramer, JJ Eckblad, R Donahue, J Brown, C Shultz, K Vickerman, ...
Biotechnology and bioengineering 108 (7), 1591-1602, 2011
2502011
N-terminal stretch Arg2, Arg3, Arg4 and Arg5 of human lactoferrin is essential for binding to heparin, bacterial lipopolysaccharide, human lysozyme and DNA
PHC VAN BERKEL, EJM GEERTS, AH VAN VEEN, M MERICSKAY, ...
Biochemical Journal 328 (1), 145-151, 1997
2471997
Recombinant production of mixtures of antibodies
PHC Van Berkel, A Bout, T Logtenberg, RHP Brus
US Patent 7,262,028, 2007
1742007
Glycosylated and unglycosylated human lactoferrins both bind iron and show identical affinities towards human lysozyme and bacterial lipopolysaccharide, but differ in their …
PHC Van Berkel, MEJ Geerts, HA Van Veen, PM Kooiman, FR Pieper, ...
Biochemical Journal 312 (1), 107-114, 1995
1741995
ADCT-402, a PBD dimer–containing antibody drug conjugate targeting CD19-expressing malignancies
F Zammarchi, S Corbett, L Adams, PC Tyrer, K Kiakos, N Janghra, ...
Blood, The Journal of the American Society of Hematology 131 (10), 1094-1105, 2018
1672018
The role of N‐linked glycosylation in the protection of human and bovine lactoferrin against tryptic proteolysis
HA Van Veen, MEJ Geerts, PHC Van Berkel, JH Nuijens
European journal of biochemistry 271 (4), 678-684, 2004
1472004
Enhanced Th1 response to Staphylococcus aureus infection in human lactoferrin-transgenic mice
C Guillén, IB McInnes, DM Vaughan, S Kommajosyula, PHC Van Berkel, ...
The Journal of Immunology 168 (8), 3950-3957, 2002
1402002
N-and O-glycans of recombinant human C1 inhibitor expressed in the milk of transgenic rabbits
K Koles, PHC van Berkel, FR Pieper, JH Nuijens, MLM Mannesse, ...
Glycobiology 14 (1), 51-64, 2004
1392004
ADCT-301, a pyrrolobenzodiazepine (PBD) dimer–containing antibody–drug conjugate (ADC) targeting CD25-expressing hematological malignancies
MJ Flynn, F Zammarchi, PC Tyrer, AU Akarca, N Janghra, CE Britten, ...
Molecular cancer therapeutics 15 (11), 2709-2721, 2016
1282016
Anti-galactose-α-1, 3-galactose IgE from allergic patients does not bind α-galactosylated glycans on intact therapeutic antibody Fc domains
JJL van Bueren, T Rispens, S Verploegen, T van der Palen-Merkus, ...
Nature biotechnology 29 (7), 574-576, 2011
1262011
N‐linked glycosylation is an important parameter for optimal selection of cell lines producing biopharmaceutical human IgG
PHC van Berkel, J Gerritsen, G Perdok, J Valbjørn, T Vink, ...
Biotechnology progress 25 (1), 244-251, 2009
1162009
Heterogeneity in utilization of N-glycosylation sites Asn624 and Asn138 in human lactoferrin: a study with glycosylation-site mutants
PHC BERKEL, HA VEEN, MEJ GEERTS, HA BOER, JH NUIJENS
Biochemical Journal 319 (1), 117-122, 1996
1151996
Pre-clinical pharmacology and mechanism of action of SG3199, the pyrrolobenzodiazepine (PBD) dimer warhead component of antibody-drug conjugate (ADC) payload tesirine
JA Hartley, MJ Flynn, JP Bingham, S Corbett, H Reinert, A Tiberghien, ...
Scientific reports 8 (1), 10479, 2018
1092018
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