| Guidelines for the use and interpretation of assays for monitoring autophagy DJ Klionsky, AK Abdel-Aziz, S Abdelfatah, M Abdellatif, A Abdoli, S Abel, ... autophagy, 1-382, 2021 | 7118 | 2021 |
| Targeting HIF-1 for cancer therapy GL Semenza Nature reviews cancer 3 (10), 721-732, 2003 | 6736 | 2003 |
| Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension GL Wang, BH Jiang, EA Rue, GL Semenza Proceedings of the national academy of sciences 92 (12), 5510-5514, 1995 | 6485 | 1995 |
| Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. JA Forsythe, BH Jiang, NV Iyer, F Agani, SW Leung, RD Koos, ... Molecular and cellular biology 16 (9), 4604-4613, 1996 | 4260 | 1996 |
| A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation. GL Semenza, GL Wang Molecular and cellular biology 12 (12), 5447-5454, 1992 | 3340 | 1992 |
| Overexpression of hypoxia-inducible factor 1α in common human cancers and their metastases H Zhong, AM De Marzo, E Laughner, M Lim, DA Hilton, D Zagzag, ... Cancer research 59 (22), 5830-5835, 1999 | 3280 | 1999 |
| HIF-1: mediator of physiological and pathophysiological responses to hypoxia GL Semenza Journal of applied physiology, 2000 | 3211* | 2000 |
| HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia J Kim, I Tchernyshyov, GL Semenza, CV Dang Cell metabolism 3 (3), 177-185, 2006 | 3049 | 2006 |
| Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1α NV Iyer, LE Kotch, F Agani, SW Leung, E Laughner, RH Wenger, ... Genes & development 12 (2), 149-162, 1998 | 2684 | 1998 |
| Purification and characterization of hypoxia-inducible factor 1 GL Wang, GL Semenza Journal of biological chemistry 270 (3), 1230-1237, 1995 | 2329 | 1995 |
| Regulation of Mammalian O2 Homeostasis by Hypoxia-Inducible Factor 1 GL Semenza Annual review of cell and developmental biology 15 (1), 551-578, 1999 | 2270 | 1999 |
| Hypoxia-inducible factors in physiology and medicine GL Semenza Cell 148 (3), 399-408, 2012 | 2178 | 2012 |
| Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1. GL Semenza, PH Roth, HM Fang, GL Wang Journal of biological chemistry 269 (38), 23757-23763, 1994 | 1933 | 1994 |
| Modulation of hypoxia-inducible factor 1α expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells … H Zhong, K Chiles, D Feldser, E Laughner, C Hanrahan, MM Georgescu, ... Cancer research 60 (6), 1541-1545, 2000 | 1824 | 2000 |
| Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1 GL Semenza, BH Jiang, SW Leung, R Passantino, JP Concordet, P Maire, ... Journal of Biological Chemistry 271 (51), 32529-32537, 1996 | 1744 | 1996 |
| Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics GL Semenza Oncogene 29 (5), 625-634, 2010 | 1616 | 2010 |
| General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia. GL Wang, GL Semenza Proceedings of the National Academy of Sciences 90 (9), 4304-4308, 1993 | 1599 | 1993 |
| HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1α (HIF-1α) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression E Laughner, P Taghavi, K Chiles, PC Mahon, GL Semenza Molecular and cellular biology 21 (12), 3995-4004, 2001 | 1513 | 2001 |
| FIH-1: a novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity PC Mahon, K Hirota, GL Semenza Genes & development 15 (20), 2675-2686, 2001 | 1507 | 2001 |
| Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia H Zhang, M Bosch-Marce, LA Shimoda, YS Tan, JH Baek, JB Wesley, ... Journal of Biological Chemistry 283 (16), 10892-10903, 2008 | 1477 | 2008 |
