Johannes Aerts
Johannes Aerts
Hoogleraar Medische Biochemie, Universiteit Leiden
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Marked elevation of plasma chitotriosidase activity. A novel hallmark of Gaucher disease.
CE Hollak, S van Weely, MH Van Oers, JM Aerts
The Journal of clinical investigation 93 (3), 1288-1292, 1994
Novel oral treatment of Gaucher's disease with N-butyldeoxynojirimycin (OGT 918) to decrease substrate biosynthesis
T Cox, R Lachmann, C Hollak, J Aerts, S Van Weely, M Hrebícek, F Platt, ...
The Lancet 355 (9214), 1481-1485, 2000
Elevated globotriaosylsphingosine is a hallmark of Fabry disease
JM Aerts, JE Groener, S Kuiper, WE Donker-Koopman, A Strijland, ...
Proceedings of the National Academy of Sciences 105 (8), 2812-2817, 2008
Identification of a novel acidic mammalian chitinase distinct from chitotriosidase
RG Boot, EFC Blommaart, E Swart, K Ghauharali-van der Vlugt, N Bijl, ...
Journal of biological chemistry 276 (9), 6770-6778, 2001
Therapeutic goals in the treatment of Gaucher disease
GM Pastores, NJ Weinreb, H Aerts, G Andria, TM Cox, M Giralt, ...
Seminars in hematology 41, 4-14, 2004
Cloning of a cDNA Encoding Chitotriosidase, a Human Chitinase Produced by Macrophages (∗)
RG Boot, GH Renkema, A Strijland, AJ van Zonneveld, JMFG Aerts
Journal of Biological Chemistry 270 (44), 26252-26256, 1995
The human chitotriosidase gene: nature of inherited enzyme deficiency
RG Boot, GH Renkema, M Verhoek, A Strijland, J Bliek, ...
Journal of Biological Chemistry 273 (40), 25680-25685, 1998
Chitotriosidase, a chitinase, and the 39‐kDa human cartilage glycoprotein, a chitin‐binding lectin, are homologues of family 18 glycosyl hydrolases secreted by human macrophages
GH Renkema, RG Boot, FL Au, WE Donker‐Koopman, A Strijland, ...
European Journal of Biochemistry 251 (1‐2), 504-509, 1998
Strong induction of members of the chitinase family of proteins in atherosclerosis: chitotriosidase and human cartilage gp-39 expressed in lesion macrophages
RG Boot, TAE van Achterberg, BE van Aken, GH Renkema, MJHM Jacobs, ...
Arteriosclerosis, thrombosis, and vascular biology 19 (3), 687-694, 1999
Purification and Characterization of Human Chitotriosidase, a Novel Member of the Chitinase Family of Proteins (∗)
GH Renkema, RG Boot, AO Muijsers, WE Donker-Koopman, JMFG Aerts
Journal of Biological Chemistry 270 (5), 2198-2202, 1995
Marked elevation of the chemokine CCL18/PARC in Gaucher disease: a novel surrogate marker for assessing therapeutic intervention
RG Boot, M Verhoek, M De Fost, CEM Hollak, M Maas, B Bleijlevens, ...
Blood 103 (1), 33-39, 2004
Myelin-laden macrophages are anti-inflammatory, consistent with foam cells in multiple sclerosis
LA Boven, M Van Meurs, M Van Zwam, A Wierenga-Wolf, RQ Hintzen, ...
Brain 129 (2), 517-526, 2006
Characterization of human phagocyte-derived chitotriosidase, a component of innate immunity
M van Eijk, CPAA van Roomen, GH Renkema, AP Bussink, L Andrews, ...
International immunology 17 (11), 1505-1512, 2005
Gaucher cells demonstrate a distinct macrophage phenotype and resemble alternatively activated macrophages
LA Boven, M van Meurs, RG Boot, A Mehta, L Boon, JM Aerts, JD Laman
American journal of clinical pathology 122 (3), 359-369, 2004
Glycosphingolipids—nature, function, and pharmacological modulation
T Wennekes, RJ van den Berg, RG Boot, GA van der Marel, HS Overkleeft, ...
Angewandte Chemie International Edition 48 (47), 8848-8869, 2009
Pharmacological inhibition of glucosylceramide synthase enhances insulin sensitivity
JM Aerts, R Ottenhoff, AS Powlson, A Grefhorst, M Van Eijk, ...
Diabetes 56 (5), 1341-1349, 2007
Evolution of mammalian chitinase (-like) members of family 18 glycosyl hydrolases
AP Bussink, D Speijer, JMFG Aerts, RG Boot
Genetics 177 (2), 959-970, 2007
Enzyme therapy for Fabry disease: neutralizing antibodies toward agalsidase alpha and beta
GE Linthorst, CEM Hollak, WE Donker-Koopman, A Strijland, JMFG Aerts
Kidney international 66 (4), 1589-1595, 2004
Structure of human chitotriosidase: implications for specific inhibitor design and function of mammalian chitinase-like lectins
F Fusetti, H Von Moeller, D Houston, HJ Rozeboom, BW Dijkstra, RG Boot, ...
Journal of Biological Chemistry 277 (28), 25537-25544, 2002
The role of the iminosugar N-butyldeoxynojirimycin (miglustat) in the management of type I (non-neuronopathic) Gaucher disease: a position statement
TM Cox, J Aerts, G Andria, M Beck, N Belmatoug, B Bembi, R Chertkoff, ...
Journal of inherited metabolic disease 26 (6), 513-526, 2003
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