| Highly efficient therapeutic gene editing of human hematopoietic stem cells Y Wu, J Zeng, BP Roscoe, P Liu, Q Yao, CR Lazzarotto, K Clement, ... Nature medicine 25 (5), 776-783, 2019 | 435 | 2019 |
| Analyses of the effects of all ubiquitin point mutants on yeast growth rate BP Roscoe, KM Thayer, KB Zeldovich, D Fushman, DNA Bolon Journal of molecular biology 425 (8), 1363-1377, 2013 | 250 | 2013 |
| Precise therapeutic gene correction by a simple nuclease-induced double-stranded break S Iyer, S Suresh, D Guo, K Daman, JCJ Chen, P Liu, M Zieger, K Luk, ... Nature 568 (7753), 561-565, 2019 | 109 | 2019 |
| Enhanced Cas12a editing in mammalian cells and zebrafish P Liu, K Luk, M Shin, F Idrizi, S Kwok, B Roscoe, E Mintzer, S Suresh, ... Nucleic acids research 47 (8), 4169-4180, 2019 | 100 | 2019 |
| Fitness analyses of all possible point mutations for regions of genes in yeast R Hietpas, B Roscoe, L Jiang, DNA Bolon Nature protocols 7 (7), 1382-1396, 2012 | 97 | 2012 |
| Determination of ubiquitin fitness landscapes under different chemical stresses in a classroom setting D Mavor, K Barlow, S Thompson, BA Barad, AR Bonny, CL Cario, ... Elife 5, e15802, 2016 | 78 | 2016 |
| Systematic exploration of ubiquitin sequence, E1 activation efficiency, and experimental fitness in yeast BP Roscoe, DNA Bolon Journal of molecular biology 426 (15), 2854-2870, 2014 | 72 | 2014 |
| Resistance to vemurafenib resulting from a novel mutation in the BRAFV 600 E kinase domain TR Wagenaar, L Ma, B Roscoe, SM Park, DN Bolon, MR Green Pigment cell & melanoma research 27 (1), 124-133, 2014 | 70 | 2014 |
| Viewing protein fitness landscapes through a next-gen lens JI Boucher, P Cote, J Flynn, L Jiang, A Laban, P Mishra, BP Roscoe, ... Genetics 198 (2), 461-471, 2014 | 59 | 2014 |
| Valves are a conserved feature of the zebrafish lymphatic system M Shin, T Nozaki, F Idrizi, S Isogai, K Ogasawara, K Ishida, S Yuge, ... Developmental cell 51 (3), 374-386. e5, 2019 | 42 | 2019 |
| Efficient homology-directed repair with circular single-stranded DNA donors S Iyer, A Mir, J Vega-Badillo, BP Roscoe, R Ibraheim, LJ Zhu, J Lee, P Liu, ... The CRISPR Journal 5 (5), 685-701, 2022 | 17 | 2022 |
| Efficient homology-directed repair with circular ssDNA donors S Iyer, A Mir, J Vega-Badillo, BP Roscoe, R Ibraheim, LJ Zhu, J Lee, P Liu, ... bioRxiv, 864199, 2019 | 11 | 2019 |
| Highly Efficient Therapeutic Gene Editing of BCL11A enhancer in Human Hematopoietic Stem Cells from ss-Hemoglobinopathy Patients for Fetal Hemoglobin Induction J Zeng, DE Bauer, Y Wu, BP Roscoe, P Liu, Q Yao, C Lazzarrotto, ... Blood 132, 3482, 2018 | 2 | 2018 |
| Efficient Nuclease-Based Correction of HPS1 Associated Microduplication S Suresh, S Iyer, P Liu, M Zieger, K Luk, S Maitland, BP Roscoe, ... MOLECULAR THERAPY 28 (4), 289-290, 2020 | | 2020 |
| Targeting bcl11a distal regulatory elements with a cas9-cas9 fusion for fetal hemoglobin reinduction DE Bauer, S Wolfe, MF Bolukbasi, B Roscoe, LIU Pengpeng, LUK Kevin, ... | | 2019 |
| Precise Therapeutic Gene Correction by a Simple Nuclease-Induced Double-Stranded Break S Suresh, S Iyer, D Guo, K Daman, JCJ Chen, P Liu, M Zieger, K Luk, ... MOLECULAR THERAPY 27 (4), 109-109, 2019 | | 2019 |
| Development of Orthogonal Cas9-Cas9 Fusion Proteins and Their Potential Application as ss-Hemoglobinopathy Therapeutics MF Bolukbasi, P Liu, BP Roscoe, K Luk, Y Wu, J Zheng, A Gupta, ... MOLECULAR THERAPY 26 (5), 20-20, 2018 | | 2018 |
| Restoration of Functional Glycosylation of Alpha-Dystroglycan in FKRP-Deficient iPSCs Using CRISPR/Cas9 S Iyer, D Guo, S Suresh, J Chen, A Bang, BP Roscoe, CP Emerson, ... MOLECULAR THERAPY 26 (5), 389-389, 2018 | | 2018 |
| Therapeutic Induction of Fetal Hemoglobin by Highly Efficient Cas9-Mediated BCL11A Enhancer Disruption in Sickle Cell Disease Hematopoietic Stem Cells Y Wu, J Zeng, BP Roscoe, P Liu, CR Lazzarrotto, Q Yao, MA Cole, ... MOLECULAR THERAPY 26 (5), 96-96, 2018 | | 2018 |
| BCL11A Enhancer Disruption by Cas9 RNP Editing of Hematopoietic Stem Cells Ameliorates beta-Thalassemia Pathophysiology J Zeng, Y Wu, BP Roscoe, P Liu, C Brugnara, SA Wolfe, DE Bauer MOLECULAR THERAPY 26 (5), 98-98, 2018 | | 2018 |
Daniel BolonProfessor of Biochemistry, University of Massachusetts Medical SchoolVerified email at umassmed.edu
