| Through the “gatekeeper door”: exploiting the active kinase conformation F Zuccotto, E Ardini, E Casale, M Angiolini Journal of medicinal chemistry 53 (7), 2681-2694, 2010 | 622 | 2010 |
| A novel multiple-stage antimalarial agent that inhibits protein synthesis B Baragaña, I Hallyburton, MCS Lee, NR Norcross, R Grimaldi, TD Otto, ... Nature 522 (7556), 315-320, 2015 | 435 | 2015 |
| Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition S Wyllie, S Brand, M Thomas, M De Rycker, C Chung, I Pena, ... Proceedings of the National Academy of Sciences 116 (19), 9318-9323, 2019 | 125 | 2019 |
| Prediction of drug penetration in tuberculosis lesions JP Sarathy, F Zuccotto, H Hsinpin, L Sandberg, LE Via, GA Marriner, ... ACS infectious diseases 2 (8), 552-563, 2016 | 125 | 2016 |
| Cyclin-dependent kinase 12 is a drug target for visceral leishmaniasis S Wyllie, M Thomas, S Patterson, S Crouch, M De Rycker, R Lowe, ... Nature 560 (7717), 192-197, 2018 | 124 | 2018 |
| Discovery of 2-[1-(4,4-Difluorocyclohexyl)piperidin-4-yl]-6-fluoro-3-oxo-2,3-dihydro-1H-isoindole-4-carboxamide (NMS-P118): A Potent, Orally Available, and … G Papeo, H Posteri, D Borghi, AA Busel, F Caprera, E Casale, M Ciomei, ... Journal of medicinal chemistry 58 (17), 6875-6898, 2015 | 111 | 2015 |
| Clinical and veterinary trypanocidal benzoxaboroles target CPSF3 RJ Wall, E Rico, I Lukac, F Zuccotto, S Elg, IH Gilbert, Y Freund, ... Proceedings of the National Academy of Sciences 115 (38), 9616-9621, 2018 | 110 | 2018 |
| Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis B Baragaña, B Forte, R Choi, S Nakazawa Hewitt, JA Bueren-Calabuig, ... Proceedings of the National Academy of Sciences 116 (14), 7015-7020, 2019 | 105 | 2019 |
| Design and synthesis of lipophilic phosphoramidate d4T-MP prodrugs expressing high potency against HIV in cell culture: structural determinants for in vitro activity and QSAR AQ Siddiqui, C McGuigan, C Ballatore, F Zuccotto, IH Gilbert, E De Clercq, ... Journal of medicinal chemistry 42 (20), 4122-4128, 1999 | 104 | 1999 |
| Novel inhibitors of Trypanosoma cruzi dihydrofolate reductase F Zuccotto, M Zvelebil, R Brun, SF Chowdhury, R Di Lucrezia, I Leal, ... European journal of medicinal chemistry 36 (5), 395-405, 2001 | 90 | 2001 |
| Essential but Not Vulnerable: Indazole Sulfonamides Targeting Inosine Monophosphate Dehydrogenase as Potential Leads against Mycobacterium tuberculosis Y Park, A Pacitto, T Bayliss, LAT Cleghorn, Z Wang, T Hartman, K Arora, ... ACS infectious diseases 3 (1), 18-33, 2017 | 85 | 2017 |
| 2, 4-Diaminopyrimidines as inhibitors of leishmanial and trypanosomal dihydrofolate reductase D Pez, I Leal, F Zuccotto, C Boussard, R Brun, SL Croft, V Yardley, ... Bioorganic & medicinal chemistry 11 (22), 4693-4711, 2003 | 84 | 2003 |
| Dihydrofolate reductase: a potential drug target in trypanosomes and leishmania F Zuccotto, ACR Martin, RA Laskowski, JM Thornton, IH Gilbert Journal of computer-aided molecular design 12, 241-257, 1998 | 77 | 1998 |
| Sugar mimics: an artificial receptor for cholera toxin A Bernardi, A Checchia, P Brocca, S Sonnino, F Zuccotto Journal of the American Chemical Society 121 (10), 2032-2036, 1999 | 69 | 1999 |
| Pharmacological Validation of N-Myristoyltransferase as a Drug Target in Leishmania donovani V Corpas-Lopez, S Moniz, M Thomas, RJ Wall, LS Torrie, D Zander-Dinse, ... ACS infectious diseases 5 (1), 111-122, 2018 | 62 | 2018 |
| Identification of Morpholino Thiophenes as Novel Mycobacterium tuberculosis Inhibitors, Targeting QcrB LAT Cleghorn, PC Ray, J Odingo, A Kumar, H Wescott, A Korkegian, ... Journal of Medicinal Chemistry 61 (15), 6592-6608, 2018 | 56 | 2018 |
| The structure-based design and synthesis of selective inhibitors of Trypanosoma cruzi dihydrofolate reductase F Zuccotto, R Brun, DG Pacanowska, LMR Perez, IH Gilbert Bioorganic & medicinal chemistry letters 9 (10), 1463-1468, 1999 | 43 | 1999 |
| Fragment-based hit discovery and structure-based optimization of aminotriazoloquinazolines as novel Hsp90 inhibitors E Casale, N Amboldi, MG Brasca, D Caronni, N Colombo, C Dalvit, ... Bioorganic & medicinal chemistry 22 (15), 4135-4150, 2014 | 41 | 2014 |
| DNDI-6148: a novel benzoxaborole preclinical candidate for the treatment of visceral leishmaniasis CE Mowbray, S Braillard, PA Glossop, GA Whitlock, RT Jacobs, J Speake, ... Journal of medicinal chemistry 64 (21), 16159-16176, 2021 | 37 | 2021 |
| Pharmacokinetics of β-lactam antibiotics: clues from the past to help discover long-acting oral drugs in the future PW Smith, F Zuccotto, RH Bates, MS Martinez-Martinez, KD Read, C Peet, ... ACS infectious diseases 4 (10), 1439-1447, 2018 | 37 | 2018 |
Ian GilbertHead of Biological Chemistry and Drug Discovery, University of DundeeVerified email at dundee.ac.uk
