|Effects of metformin and other biguanides on oxidative phosphorylation in mitochondria|
HR Bridges, AJY Jones, N Pollak, Michael, J Hirst
Biochemical Journal, 2014
|Cryo-EM structures of complex I from mouse heart mitochondria in two biochemically defined states|
ANA Agip, JN Blaza, HR Bridges, C Viscomi, S Rawson, SP Muench, ...
Nature structural & molecular biology 25 (7), 548-556, 2018
|Molecular features of biguanides required for targeting of mitochondrial respiratory complex I and activation of AMP-kinase|
HR Bridges, VA SirviŲ, ANA Agip, J Hirst
BMC biology 14 (1), 1-11, 2016
|Structural basis for a complex I mutation that blocks pathological ROS production|
Z Yin, N Burger, D Kula-Alwar, D Aksentijević, HR Bridges, HA Prag, ...
Nature communications 12 (1), 707, 2021
|Structure of inhibitor-bound mammalian complex I|
HR Bridges, JG Fedor, JN Blaza, A Di Luca, A Jussupow, OD Jarman, ...
Nature Communications 11 (1), 5261, 2020
|Fumarate Hydratase Loss Causes Combined Respiratory Chain Defects|
PA Tyrakis, ME Yurkovich, M Sciacovelli, EK Papachristou, HR Bridges, ...
Cell Reports 21 (4), 1036-1047, 2017
|Investigating the function of [2Fe-2S] cluster N1a, the off-pathway cluster in complex I, by manipulating its reduction potential|
JA Birrell, K Morina, HR Bridges, T Friedrich, J Hirst
Biochemical Journal 456 (1), 139-146, 2013
|The mechanism of catalysis by type-II NADH: quinone oxidoreductases|
JN Blaza, HR Bridges, D Arag„o, EA Dunn, A Heikal, GM Cook, ...
Scientific reports 7 (1), 40165, 2017
|Mossbauer spectroscopy on respiratory complex I: the iron–sulfur cluster ensemble in the NADH-reduced enzyme is partially oxidized|
HR Bridges, E Bill, J Hirst
Biochemistry 51 (1), 149-158, 2011
|Characterization of clinically identified mutations in NDUFV1, the flavin-binding subunit of respiratory complex I, using a yeast model system|
F Varghese, E Atcheson, HR Bridges, J Hirst
Human molecular genetics 24 (22), 6350-6360, 2015
|The subunit composition of mitochondrial NADH: ubiquinone oxidoreductase (complex I) from Pichia pastoris|
HR Bridges, IM Fearnley, J Hirst
Molecular & Cellular Proteomics 9 (10), 2318-2326, 2010
|Subunit NDUFV3 is present in two distinct isoforms in mammalian complex I|
HR Bridges, K Mohammed, ME Harbour, J Hirst
Biochimica et Biophysica Acta (BBA)-Bioenergetics 1858 (3), 197-207, 2017
|A Self‐Assembled Respiratory Chain that Catalyzes NADH Oxidation by Ubiquinone‐10 Cycling between Complex I and the Alternative Oxidase|
AJY Jones, JN Blaza, HR Bridges, B May, AL Moore, J Hirst
Angewandte Chemie International Edition 55 (2), 728-731, 2016
|The mitochondrial-encoded subunits of respiratory complex I (NADH: ubiquinone oxidoreductase): identifying residues important in mechanism and disease.|
HR Bridges, JA Birrell, J Hirst
Biochemical Society Transactions 39 (3), 2011
|Using Hyperfine EPR Spectroscopy to define the Proton-Coupled Electron Transfer Reaction at Fe-S Cluster N2 in Respiratory Complex I|
N Le Breton, JJ Wright, AJY Jones, E Salvadori, HR Bridges, J Hirst, ...
Journal of the American Chemical Society, 2017
|Complexome profile of Toxoplasma gondii mitochondria identifies divergent subunits of respiratory chain complexes including new subunits of cytochrome bc1 complex|
AE Maclean, HR Bridges, MF Silva, S Ding, J Ovciarikova, J Hirst, ...
PLoS pathogens 17 (3), e1009301, 2021
|Cryo-EM structures define ubiquinone-10 binding to mitochondrial complex I and conformational transitions accompanying Q-site occupancy|
I Chung, JJ Wright, HR Bridges, BS Ivanov, O Biner, CS Pereira, ...
Nature Communications 13 (1), 2758, 2022
|Structural basis of mammalian respiratory complex I inhibition by medicinal biguanides|
HR Bridges, JN Blaza, Z Yin, I Chung, MN Pollak, J Hirst
Science 379 (6630), 351-357, 2023
|Structure of the NDH-2–HQNO inhibited complex provides molecular insight into quinone-binding site inhibitors|
J Petri, Y Shimaki, W Jiao, HR Bridges, ER Russell, EJ Parker, D Arag„o, ...
Biochimica et Biophysica Acta (BBA)-Bioenergetics 1859 (7), 482-490, 2018
|Repression of LKB1 by miR-17∼ 92 sensitizes MYC-dependent lymphoma to biguanide treatment|
S Izreig, A Gariepy, I Kaymak, HR Bridges, AO Donayo, G Bridon, ...
Cell Reports Medicine 1 (2), 2020