Hannah Bridges
Cited by
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Effects of metformin and other biguanides on oxidative phosphorylation in mitochondria
HR Bridges, AJY Jones, N Pollak, Michael, J Hirst
Biochemical Journal, 2014
Cryo-EM structures of complex I from mouse heart mitochondria in two biochemically defined states
ANA Agip, JN Blaza, HR Bridges, C Viscomi, S Rawson, SP Muench, ...
Nature structural & molecular biology 25 (7), 548-556, 2018
Molecular features of biguanides required for targeting of mitochondrial respiratory complex I and activation of AMP-kinase
HR Bridges, VA SirviŲ, ANA Agip, J Hirst
BMC biology 14 (1), 1-11, 2016
Structural basis for a complex I mutation that blocks pathological ROS production
Z Yin, N Burger, D Kula-Alwar, D Aksentijević, HR Bridges, HA Prag, ...
Nature communications 12 (1), 707, 2021
Structure of inhibitor-bound mammalian complex I
HR Bridges, JG Fedor, JN Blaza, A Di Luca, A Jussupow, OD Jarman, ...
Nature Communications 11 (1), 5261, 2020
Fumarate Hydratase Loss Causes Combined Respiratory Chain Defects
PA Tyrakis, ME Yurkovich, M Sciacovelli, EK Papachristou, HR Bridges, ...
Cell Reports 21 (4), 1036-1047, 2017
Investigating the function of [2Fe-2S] cluster N1a, the off-pathway cluster in complex I, by manipulating its reduction potential
JA Birrell, K Morina, HR Bridges, T Friedrich, J Hirst
Biochemical Journal 456 (1), 139-146, 2013
The mechanism of catalysis by type-II NADH: quinone oxidoreductases
JN Blaza, HR Bridges, D Arag„o, EA Dunn, A Heikal, GM Cook, ...
Scientific reports 7 (1), 40165, 2017
Mossbauer spectroscopy on respiratory complex I: the iron–sulfur cluster ensemble in the NADH-reduced enzyme is partially oxidized
HR Bridges, E Bill, J Hirst
Biochemistry 51 (1), 149-158, 2011
Characterization of clinically identified mutations in NDUFV1, the flavin-binding subunit of respiratory complex I, using a yeast model system
F Varghese, E Atcheson, HR Bridges, J Hirst
Human molecular genetics 24 (22), 6350-6360, 2015
The subunit composition of mitochondrial NADH: ubiquinone oxidoreductase (complex I) from Pichia pastoris
HR Bridges, IM Fearnley, J Hirst
Molecular & Cellular Proteomics 9 (10), 2318-2326, 2010
Subunit NDUFV3 is present in two distinct isoforms in mammalian complex I
HR Bridges, K Mohammed, ME Harbour, J Hirst
Biochimica et Biophysica Acta (BBA)-Bioenergetics 1858 (3), 197-207, 2017
A Self‐Assembled Respiratory Chain that Catalyzes NADH Oxidation by Ubiquinone‐10 Cycling between Complex I and the Alternative Oxidase
AJY Jones, JN Blaza, HR Bridges, B May, AL Moore, J Hirst
Angewandte Chemie International Edition 55 (2), 728-731, 2016
The mitochondrial-encoded subunits of respiratory complex I (NADH: ubiquinone oxidoreductase): identifying residues important in mechanism and disease.
HR Bridges, JA Birrell, J Hirst
Biochemical Society Transactions 39 (3), 2011
Using Hyperfine EPR Spectroscopy to define the Proton-Coupled Electron Transfer Reaction at Fe-S Cluster N2 in Respiratory Complex I
N Le Breton, JJ Wright, AJY Jones, E Salvadori, HR Bridges, J Hirst, ...
Journal of the American Chemical Society, 2017
Complexome profile of Toxoplasma gondii mitochondria identifies divergent subunits of respiratory chain complexes including new subunits of cytochrome bc1 complex
AE Maclean, HR Bridges, MF Silva, S Ding, J Ovciarikova, J Hirst, ...
PLoS pathogens 17 (3), e1009301, 2021
Cryo-EM structures define ubiquinone-10 binding to mitochondrial complex I and conformational transitions accompanying Q-site occupancy
I Chung, JJ Wright, HR Bridges, BS Ivanov, O Biner, CS Pereira, ...
Nature Communications 13 (1), 2758, 2022
Structural basis of mammalian respiratory complex I inhibition by medicinal biguanides
HR Bridges, JN Blaza, Z Yin, I Chung, MN Pollak, J Hirst
Science 379 (6630), 351-357, 2023
Structure of the NDH-2–HQNO inhibited complex provides molecular insight into quinone-binding site inhibitors
J Petri, Y Shimaki, W Jiao, HR Bridges, ER Russell, EJ Parker, D Arag„o, ...
Biochimica et Biophysica Acta (BBA)-Bioenergetics 1859 (7), 482-490, 2018
Repression of LKB1 by miR-17∼ 92 sensitizes MYC-dependent lymphoma to biguanide treatment
S Izreig, A Gariepy, I Kaymak, HR Bridges, AO Donayo, G Bridon, ...
Cell Reports Medicine 1 (2), 2020
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Articles 1–20