Evolutionary drivers of thermoadaptation in enzyme catalysis V Nguyen, C Wilson, M Hoemberger, JB Stiller, RV Agafonov, S Kutter, ... Science 355 (6322), 289-294, 2017 | 192 | 2017 |
Using ancient protein kinases to unravel a modern cancer drug’s mechanism C Wilson, RV Agafonov, M Hoemberger, S Kutter, A Zorba, J Halpin, ... Science 347 (6224), 882-886, 2015 | 183 | 2015 |
Predicting multiple conformations via sequence clustering and AlphaFold2 HK Wayment-Steele, A Ojoawo, R Otten, JM Apitz, W Pitsawong, ... Nature 625 (7996), 832-839, 2024 | 53 | 2024 |
Cumulative mechanism of several major imatinib-resistant mutations in Abl kinase M Hoemberger, W Pitsawong, D Kern Proceedings of the National Academy of Sciences 117 (32), 19221-19227, 2020 | 35 | 2020 |
Allosteric modulation of a human protein kinase with monobodies A Zorba, V Nguyen, A Koide, M Hoemberger, Y Zheng, S Kutter, C Kim, ... Proceedings of the National Academy of Sciences 116 (28), 13937-13942, 2019 | 35 | 2019 |
Probing the transition state in enzyme catalysis by high-pressure NMR dynamics JB Stiller, S Jordan Kerns, M Hoemberger, YJ Cho, R Otten, MF Hagan, ... Nature catalysis 2 (8), 726-734, 2019 | 31 | 2019 |
Discovery and preclinical characterization of BIIB091, a reversible, selective BTK inhibitor for the treatment of multiple sclerosis BT Hopkins, E Bame, B Bajrami, C Black, T Bohnert, C Boiselle, ... Journal of Medicinal Chemistry 65 (2), 1206-1224, 2021 | 23 | 2021 |
From primordial clocks to circadian oscillators W Pitsawong, RAP Pádua, T Grant, M Hoemberger, R Otten, N Bradshaw, ... Nature 616 (7955), 183-189, 2023 | 11 | 2023 |
Optimization of a novel piperazinone series as potent selective peripheral covalent BTK inhibitors B Ma, CM Metrick, C Gu, M Hoemberger, B Bajrami, E Bame, J Huang, ... Bioorganic & Medicinal Chemistry Letters 60, 128549, 2022 | 5 | 2022 |
Probing an ancient protein's dynamics with NMR MS Hoemberger, CG Wilson, D Kern Biophysical journal 106 (2), 657a, 2014 | 3 | 2014 |
Discovery and Preclinical Characterization of BIIB129, a Covalent, Selective, and Brain-Penetrant BTK Inhibitor for the Treatment of Multiple Sclerosis MK Himmelbauer, B Bajrami, R Basile, A Capacci, TY Chen, CK Choi, ... Journal of Medicinal Chemistry, 2024 | | 2024 |
From primordial clocks to circadian oscillators N Bradshaw, W Pitsawong, R Ap Pádua, T Grant, M Hoemberger, R Otten, ... Nature, 2023 | | 2023 |
Optimization of a novel piperazinone series as potent selective peripheral covalent BTK inhibitors (vol 60, 128549, 2022) B Ma, CM Metrick, C Gu, M Hoemberger, B Bajrami, E Bame, J Huang, ... BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 72, 2022 | | 2022 |
Natural evolution sheds light on modern drug resistance in protein kinases M Hoemberger, C Wilson, R Agafonov, D Kern PROTEIN SCIENCE 24, 310-310, 2015 | | 2015 |