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Jean Dam
Jean Dam
Medicinal Chemist, University of Cape Town
Geverifieerd e-mailadres voor uct.ac.za
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Synthesis of copper and zinc 2-(pyridin-2-yl) imidazo [1, 2-a] pyridine complexes and their potential anticancer activity
J Dam, Z Ismail, T Kurebwa, N Gangat, L Harmse, HM Marques, ...
European journal of medicinal chemistry 126, 353-368, 2017
802017
Identification and profiling of a novel diazaspiro [3.4] octane chemical series active against multiple stages of the human malaria parasite Plasmodium falciparum and …
C Le Manach, J Dam, JG Woodland, G Kaur, LP Khonde, C Brunschwig, ...
Journal of Medicinal Chemistry 64 (4), 2291-2309, 2021
192021
Identification of 2, 4-Disubstituted Imidazopyridines as Hemozoin Formation Inhibitors with Fast-Killing Kinetics and In Vivo Efficacy in the Plasmodium falciparum NSG Mouse Model
A Horatscheck, A Andrijevic, AT Nchinda, C Le Manach, T Paquet, ...
Journal of Medicinal Chemistry 63 (21), 13013-13030, 2020
152020
Copper-imidazo[1,2-a]pyridines induce intrinsic apoptosis and modulate the expression of mutated p53, haem-oxygenase-1 and apoptotic inhibitory proteins in HT …
L Harmse, N Gangat, C Martins-Furness, J Dam, CB de Koning
Apoptosis 24 (7-8), 623-643, 2019
142019
Copper-imidazo [1, 2-a] pyridines differentially modulate pro-and anti-apoptotic protein and gene expression in HL-60 and K562 leukaemic cells to cause apoptotic cell death
Z Ismail, J Dam, C Penny, CB de Koning, L Harmse
Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1869 (1), 119160, 2022
82022
Ceric ammonium sulfate (CAS) mediated oxidations of benzophenones possessing a phenolic substituent for the synthesis of xanthones and related products
J Dam, ML Bode, CB de Koning
The Journal of organic chemistry 84 (1), 150-160, 2018
72018
Synthetic, mechanistic and biological studies of novel metal-imidazo [1, 2-a] pyridines and xanthones
J Dam
12016
Correction to “Identification of 2, 4-Disubstituted Imidazopyridines as Hemozoin Formation Inhibitors with Fast-Killing Kinetics and In Vivo Efficacy in the Plasmodium …
A Horatscheck, A Andrijevic, AT Nchinda, C Le Manach, T Paquet, ...
Journal of Medicinal Chemistry 64 (3), 1762-1762, 2021
2021
THE EFFECTS OF NOVEL 7-AZAINDOLES AND 6-SUBSTITUTED IMIDAZOLES ON MCF-7 BREAST CANCER CELLS: 507
T Kurebwa, C de Koning, L Harmse, J Dam
Basic & Clinical Pharmacology & Toxicology 115, 2014
2014
novel Imidazo [1, 2-a] Pyridines As Potential Antileukaemic Agents: 440
Z Ismail, C de Koning, L Harmse, J Dam
Basic & Clinical Pharmacology & Toxicology 115, 134-135, 2014
2014
THE CYTOTOXIC EFFECTS OF AZAINDOLES AND IMIDAZOPYRIDINES ON COLON CANCER CELL LINES: 504
S Ragie, L Harmse, C de Koning, J Dam
Basic & Clinical Pharmacology & Toxicology 115, 2014
2014
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Artikelen 1–11