| Modulation of splicing catalysis for therapeutic targeting of leukemia with mutations in genes encoding spliceosomal proteins SCW Lee, H Dvinge, E Kim, H Cho, JB Micol, YR Chung, BH Durham, ... Nature medicine 22 (6), 672-678, 2016 | 358 | 2016 |
| RNA demethylase ALKBH5 selectively promotes tumorigenesis and cancer stem cell self-renewal in acute myeloid leukemia C Shen, Y Sheng, AC Zhu, S Robinson, X Jiang, L Dong, H Chen, R Su, ... Cell stem cell 27 (1), 64-80. e9, 2020 | 272 | 2020 |
| Androgen receptor is a new potential therapeutic target for the treatment of hepatocellular carcinoma WL Ma, CL Hsu, MH Wu, CT Wu, CC Wu, JJ Lai, YS Jou, CW Chen, S Yeh, ... Gastroenterology 135 (3), 947-955. e5, 2008 | 258 | 2008 |
| DOT1L inhibits SIRT1-mediated epigenetic silencing to maintain leukemic gene expression in MLL-rearranged leukemia CW Chen, RP Koche, AU Sinha, AJ Deshpande, N Zhu, R Eng, ... Nature medicine 21 (4), 335-343, 2015 | 230 | 2015 |
| A UTX-MLL4-p300 transcriptional regulatory network coordinately shapes active enhancer landscapes for eliciting transcription SP Wang, Z Tang, CW Chen, M Shimada, RP Koche, LH Wang, ... Molecular cell 67 (2), 308-321. e6, 2017 | 206 | 2017 |
| Targeting Chromatin Regulators Inhibits Leukemogenic Gene Expression in NPM1 Mutant Leukemia MWM Kühn, E Song, Z Feng, A Sinha, CW Chen, AJ Deshpande, ... Cancer discovery 6 (10), 1166-1181, 2016 | 203 | 2016 |
| R-2-hydroxyglutarate attenuates aerobic glycolysis in leukemia by targeting the FTO/m6A/PFKP/LDHB axis Y Qing, L Dong, L Gao, C Li, Y Li, L Han, E Prince, B Tan, X Deng, ... Molecular cell 81 (5), 922-939. e9, 2021 | 192 | 2021 |
| AF10 regulates progressive H3K79 methylation and HOX gene expression in diverse AML subtypes AJ Deshpande, A Deshpande, AU Sinha, L Chen, J Chang, A Cihan, ... Cancer cell 26 (6), 896-908, 2014 | 182 | 2014 |
| METTL16 exerts an m6A-independent function to facilitate translation and tumorigenesis R Su, L Dong, Y Li, M Gao, PC He, W Liu, J Wei, Z Zhao, L Gao, L Han, ... Nature cell biology 24 (2), 205-216, 2022 | 165 | 2022 |
| Type I and II collagen regulation of chondrogenic differentiation by mesenchymal progenitor cells CW Chen, YH Tsai, WP Deng, SN Shih, CL Fang, JG Burch, WH Chen, ... Journal of orthopaedic research 23 (2), 446-453, 2005 | 143 | 2005 |
| Targeting DOT1L and HOX gene expression in MLL-rearranged leukemia and beyond CW Chen, SA Armstrong Experimental hematology 43 (8), 673-684, 2015 | 131 | 2015 |
| NUP98 fusion proteins interact with the NSL and MLL1 complexes to drive leukemogenesis H Xu, DG Valerio, ME Eisold, A Sinha, RP Koche, W Hu, CW Chen, ... Cancer cell 30 (6), 863-878, 2016 | 124 | 2016 |
| MLL-AF9–and HOXA9-mediated acute myeloid leukemia stem cell self-renewal requires JMJD1C N Zhu, M Chen, R Eng, J DeJong, AU Sinha, NF Rahnamay, R Koche, ... The Journal of clinical investigation 126 (3), 997-1011, 2016 | 103 | 2016 |
| A non-catalytic function of SETD1A regulates cyclin K and the DNA damage response T Hoshii, P Cifani, Z Feng, CH Huang, R Koche, CW Chen, CD Delaney, ... Cell 172 (5), 1007-1021. e17, 2018 | 100 | 2018 |
| CAR T cells targeting BAFF-R can overcome CD19 antigen loss in B cell malignancies H Qin, Z Dong, X Wang, WA Cheng, F Wen, W Xue, H Sun, M Walter, ... Science translational medicine 11 (511), eaaw9414, 2019 | 76 | 2019 |
| Rewiring the Epigenetic Networks in MLL-Rearranged Leukemias: Epigenetic Dysregulation and Pharmacological Interventions AKN Chan, CW Chen Frontiers in cell and developmental biology 7, 81, 2019 | 74 | 2019 |
| IFITM3 functions as a PIP3 scaffold to amplify PI3K signalling in B cells J Lee, ME Robinson, N Ma, D Artadji, MA Ahmed, G Xiao, T Sadras, ... Nature 588 (7838), 491-497, 2020 | 68 | 2020 |
| Synergistic targeting of FLT3 mutations in AML via combined menin-MLL and FLT3 inhibition MM Dzama, M Steiner, J Rausch, D Sasca, J Schönfeld, K Kunz, ... Blood, The Journal of the American Society of Hematology 136 (21), 2442-2456, 2020 | 67 | 2020 |
| PRMT1-mediated FLT3 arginine methylation promotes maintenance of FLT3-ITD+ acute myeloid leukemia X He, Y Zhu, YC Lin, M Li, J Du, H Dong, J Sun, L Zhu, H Wang, Z Ding, ... Blood, The Journal of the American Society of Hematology 134 (6), 548-560, 2019 | 61 | 2019 |
| Drugging chromatin in cancer: recent advances and novel approaches SF Cai, CW Chen, SA Armstrong Molecular cell 60 (4), 561-570, 2015 | 57 | 2015 |
Aniruddha Jayant DeshpandeAssistant Professor, Sanford Burnham Medical Research InstituteVerified email at sanfordburnham.org
