| Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases SM Man, R Karki, TD Kanneganti Immunological reviews 277 (1), 61-75, 2017 | 1378 | 2017 |
| Synergism of TNF-α and IFN-γ triggers inflammatory cell death, tissue damage, and mortality in SARS-CoV-2 infection and cytokine shock syndromes R Karki, BR Sharma, S Tuladhar, EP Williams, L Zalduondo, P Samir, ... Cell 184 (1), 149-168. e17, 2021 | 1127 | 2021 |
| ZBP1/DAI is an innate sensor of influenza virus triggering the NLRP3 inflammasome and programmed cell death pathways T Kuriakose, SM Man, RK Subbarao Malireddi, R Karki, S Kesavardhana, ... Science immunology 1 (2), aag2045-aag2045, 2016 | 545 | 2016 |
| Diverging inflammasome signals in tumorigenesis and potential targeting R Karki, TD Kanneganti Nature Reviews Cancer 19 (4), 197-214, 2019 | 493 | 2019 |
| TLR2 senses the SARS-CoV-2 envelope protein to produce inflammatory cytokines M Zheng, R Karki, EP Williams, D Yang, E Fitzpatrick, P Vogel, ... Nature immunology 22 (7), 829-838, 2021 | 445 | 2021 |
| The transcription factor IRF1 and guanylate-binding proteins target activation of the AIM2 inflammasome by Francisella infection SM Man, R Karki, RKS Malireddi, G Neale, P Vogel, M Yamamoto, ... Nature immunology 16 (5), 467-475, 2015 | 346 | 2015 |
| Inflammasomes and cancer R Karki, SM Man, TD Kanneganti Cancer immunology research 5 (2), 94-99, 2017 | 343 | 2017 |
| AIM2 inflammasome in infection, cancer, and autoimmunity: Role in DNA sensing, inflammation, and innate immunity SM Man, R Karki, TD Kanneganti European journal of immunology 46 (2), 269-280, 2016 | 323 | 2016 |
| Critical role for the DNA sensor AIM2 in stem cell proliferation and cancer SM Man, Q Zhu, L Zhu, Z Liu, R Karki, A Malik, D Sharma, L Li, ... Cell 162 (1), 45-58, 2015 | 309 | 2015 |
| Caspase-6 is a key regulator of innate immunity, inflammasome activation, and host defense M Zheng, R Karki, P Vogel, TD Kanneganti Cell 181 (3), 674-687. e13, 2020 | 299 | 2020 |
| DDX3X acts as a live-or-die checkpoint in stressed cells by regulating NLRP3 inflammasome P Samir, S Kesavardhana, DM Patmore, S Gingras, RKS Malireddi, ... Nature 573 (7775), 590-594, 2019 | 292 | 2019 |
| IRGB10 liberates bacterial ligands for sensing by the AIM2 and caspase-11-NLRP3 inflammasomes SM Man, R Karki, M Sasai, DE Place, S Kesavardhana, J Temirov, ... Cell 167 (2), 382-396. e17, 2016 | 280 | 2016 |
| Identification of the PANoptosome: a molecular platform triggering pyroptosis, apoptosis, and necroptosis (PANoptosis) S Christgen, M Zheng, S Kesavardhana, R Karki, RKS Malireddi, ... Frontiers in cellular and infection microbiology 10, 237, 2020 | 265 | 2020 |
| Concerted activation of the AIM2 and NLRP3 inflammasomes orchestrates host protection against Aspergillus infection R Karki, SM Man, RKS Malireddi, P Gurung, P Vogel, M Lamkanfi, ... Cell host & microbe 17 (3), 357-368, 2015 | 262 | 2015 |
| AIM2 forms a complex with pyrin and ZBP1 to drive PANoptosis and host defence SJ Lee, R Karki, Y Wang, LN Nguyen, RC Kalathur, TD Kanneganti Nature 597 (7876), 415-419, 2021 | 254 | 2021 |
| Role of AIM2 inflammasome in inflammatory diseases, cancer and infection BR Sharma, R Karki, TD Kanneganti European journal of immunology 49 (11), 1998-2011, 2019 | 204 | 2019 |
| The ‘cytokine storm’: molecular mechanisms and therapeutic prospects R Karki, TD Kanneganti Trends in immunology 42 (8), 681-705, 2021 | 195 | 2021 |
| NLRC3 is an inhibitory sensor of PI3K–mTOR pathways in cancer R Karki, SM Man, RKS Malireddi, S Kesavardhana, Q Zhu, AR Burton, ... Nature 540 (7634), 583-587, 2016 | 177 | 2016 |
| ADAR1 restricts ZBP1-mediated immune response and PANoptosis to promote tumorigenesis R Karki, B Sundaram, BR Sharma, SJ Lee, RKS Malireddi, LN Nguyen, ... Cell reports 37 (3), 2021 | 174 | 2021 |
| IL-33 regulates the IgA-microbiota axis to restrain IL-1α–dependent colitis and tumorigenesis A Malik, D Sharma, Q Zhu, R Karki, CS Guy, P Vogel, TD Kanneganti The Journal of clinical investigation 126 (12), 4469-4481, 2016 | 171 | 2016 |
Thirumala-Devi KannegantiSt. Jude Children's Research HospitalVerified email at stjude.org
