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Gillian Bates
Gillian Bates
Professor of Molecular Neuroscience, UCL
Geverifieerd e-mailadres voor ucl.ac.uk
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A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes
ME MacDonald, CM Ambrose, MP Duyao, RH Myers, C Lin, L Srinidhi, ...
Cell 72 (6), 971-983, 1993
73251993
Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice
L Mangiarini, K Sathasivam, M Seller, B Cozens, A Harper, ...
Cell 87 (3), 493-506, 1996
35671996
Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain
M DiFiglia, E Sapp, KO Chase, SW Davies, GP Bates, JP Vonsattel, ...
Science 277 (5334), 1990-1993, 1997
33031997
Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation
SW Davies, M Turmaine, BA Cozens, M DiFiglia, AH Sharp, CA Ross, ...
Cell 90 (3), 537-548, 1997
26981997
Huntingtin-encoded polyglutamine expansions form amyloid-like protein aggregates in vitro and in vivo
E Scherzinger, R Lurz, M Turmaine, L Mangiarini, B Hollenbach, ...
Cell 90 (3), 549-558, 1997
15801997
Huntington disease
GP Bates, R Dorsey, JF Gusella, MR Hayden, C Kay, BR Leavitt, M Nance, ...
Nature reviews Disease primers 1 (1), 1-21, 2015
14452015
The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription
JS Steffan, A Kazantsev, O Spasic-Boskovic, M Greenwald, YZ Zhu, ...
Proceedings of the National Academy of Sciences 97 (12), 6763-6768, 2000
12752000
Characterization of progressive motor deficits in mice transgenic for the human Huntington’s disease mutation
RJ Carter, LA Lione, T Humby, L Mangiarini, A Mahal, GP Bates, ...
Journal of Neuroscience 19 (8), 3248-3257, 1999
11981999
Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, ameliorates motor deficits in a mouse model of Huntington's disease
E Hockly, VM Richon, B Woodman, DL Smith, X Zhou, E Rosa, ...
Proceedings of the National Academy of Sciences 100 (4), 2041-2046, 2003
10462003
Self-assembly of polyglutamine-containing huntingtin fragments into amyloid-like fibrils: implications for Huntington’s disease pathology
E Scherzinger, A Sittler, K Schweiger, V Heiser, R Lurz, R Hasenbank, ...
Proceedings of the National Academy of Sciences 96 (8), 4604-4609, 1999
8711999
A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease
M Björkqvist, EJ Wild, J Thiele, A Silvestroni, R Andre, N Lahiri, ...
The Journal of experimental medicine 205 (8), 1869-1877, 2008
7162008
A novel gene encoding an integral membrane protein is mutated in nephropathic cystinosis
M Town, G Jean, S Cherqui, M Attard, L Forestier, SA Whitmore, ...
Nature genetics 18 (4), 319-324, 1998
6971998
Huntington's disease
G Bates, S Tabrizi, L Jones
Oxford University Press, 2014
6922014
Huntingtin aggregation and toxicity in Huntington's disease
G Bates
The Lancet 361 (9369), 1642-1644, 2003
6522003
Huntingtin and the molecular pathogenesis of Huntington's disease: Fourth in Molecular Medicine Review Series
C Landles, GP Bates
EMBO reports 5 (10), 958-963, 2004
6242004
Altered brain neurotransmitter receptors in transgenic mice expressing a portion of an abnormal human huntington disease gene
JHJ Cha, CM Kosinski, JA Kerner, SA Alsdorf, L Mangiarini, SW Davies, ...
Proceedings of the National Academy of Sciences 95 (11), 6480-6485, 1998
6191998
Global changes to the ubiquitin system in Huntington's disease
EJ Bennett, TA Shaler, B Woodman, KY Ryu, TS Zaitseva, CH Becker, ...
Nature 448 (7154), 704-708, 2007
5992007
Intranuclear neuronal inclusions in Huntington's disease and Dentatorubral and Pallidoluysian atrophy: correlation between the density of inclusions andIT15CAG triplet repeat …
MW Becher, JA Kotzuk, AH Sharp, SW Davies, GP Bates, DL Price, ...
Neurobiology of disease 4 (6), 387-397, 1998
5701998
Nonapoptotic neurodegeneration in a transgenic mouse model of Huntington's disease
M Turmaine, A Raza, A Mahal, L Mangiarini, GP Bates, SW Davies
Proceedings of the National Academy of Sciences 97 (14), 8093-8097, 2000
5192000
Aberrant splicing of HTT generates the pathogenic exon 1 protein in Huntington disease
K Sathasivam, A Neueder, TA Gipson, C Landles, AC Benjamin, ...
Proceedings of the National Academy of Sciences 110 (6), 2366-2370, 2013
5102013
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