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Sanne Smeekens
Sanne Smeekens
Clinical Laboratory Geneticist
Geverifieerd e-mailadres voor radboudumc.nl
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Linking the human gut microbiome to inflammatory cytokine production capacity
M Schirmer, SP Smeekens, H Vlamakis, M Jaeger, M Oosting, ...
Cell 167 (4), 1125-1136. e8, 2016
10392016
The effect of host genetics on the gut microbiome
MJ Bonder, A Kurilshikov, EF Tigchelaar, Z Mujagic, F Imhann, AV Vila, ...
Nature genetics 48 (11), 1407-1412, 2016
7522016
STAT1 Mutations in Autosomal Dominant Chronic Mucocutaneous Candidiasis
FL van de Veerdonk, TS Plantinga, A Hoischen, SP Smeekens, ...
New England Journal of Medicine 365 (1), 54-61, 2011
7212011
Host and environmental factors influencing individual human cytokine responses
R Ter Horst, M Jaeger, SP Smeekens, M Oosting, MA Swertz, Y Li, ...
Cell 167 (4), 1111-1124. e13, 2016
4582016
A functional genomics approach to understand variation in cytokine production in humans
Y Li, M Oosting, SP Smeekens, M Jaeger, R Aguirre-Gamboa, KTT Le, ...
Cell 167 (4), 1099-1110. e14, 2016
3132016
IL-1 receptor blockade restores autophagy and reduces inflammation in chronic granulomatous disease in mice and in humans
A de Luca, SP Smeekens, A Casagrande, R Iannitti, KL Conway, ...
Proceedings of the National Academy of Sciences 111 (9), 3526-3531, 2014
3072014
Gut microbiome in ADHD and its relation to neural reward anticipation
E Aarts, THA Ederveen, J Naaijen, MP Zwiers, J Boekhorst, ...
PloS one 12 (9), e0183509, 2017
2812017
Reactive oxygen species–independent activation of the IL-1β inflammasome in cells from patients with chronic granulomatous disease
FL van de Veerdonk, SP Smeekens, LAB Joosten, BJ Kullberg, ...
Proceedings of the National Academy of Sciences 107 (7), 3030-3033, 2010
2662010
The dectin-1/inflammasome pathway is responsible for the induction of protective T-helper 17 responses that discriminate between yeasts and hyphae of Candida albicans
SC Cheng, FL van de Veerdonk, M Lenardon, M Stoffels, T Plantinga, ...
Journal of leukocyte biology 90 (2), 357-366, 2011
2142011
Functional genomics identifies type I interferon pathway as central for host defense against Candida albicans
SP Smeekens, A Ng, V Kumar, MD Johnson, TS Plantinga, C Van Diemen, ...
Nature communications 4 (1), 1342, 2013
1952013
Inter-individual variability and genetic influences on cytokine responses to bacteria and fungi
Y Li, M Oosting, P Deelen, I Ricano-Ponce, S Smeekens, M Jaeger, ...
Nature medicine 22 (8), 952-960, 2016
1802016
Differential effects of environmental and genetic factors on T and B cell immune traits
R Aguirre-Gamboa, I Joosten, PCM Urbano, RG van der Molen, ...
Cell reports 17 (9), 2474-2487, 2016
1792016
The inflammasome drives protective Th1 and Th17 cellular responses in disseminated candidiasis
FL van de Veerdonk, LAB Joosten, PJ Shaw, SP Smeekens, ...
European journal of immunology 41 (8), 2260-2268, 2011
1552011
Genetic susceptibility to Candida infections
SP Smeekens, FL van de Veerdonk, BJ Kullberg, MG Netea
EMBO molecular medicine 5 (6), 805-813, 2013
1512013
STAT1 hyperphosphorylation and defective IL12R/IL23R signaling underlie defective immunity in autosomal dominant chronic mucocutaneous candidiasis
SP Smeekens, TS Plantinga, FL van de Veerdonk, B Heinhuis, ...
PloS one 6 (12), e29248, 2011
1312011
Gain‐of‐function STAT1 mutations impair STAT3 activity in patients with chronic mucocutaneous candidiasis (CMC)
J Zheng, FL van de Veerdonk, KL Crossland, SP Smeekens, CM Chan, ...
European journal of immunology 45 (10), 2834-2846, 2015
1232015
Integration of multi-omics data and deep phenotyping enables prediction of cytokine responses
OB Bakker, R Aguirre-Gamboa, S Sanna, M Oosting, SP Smeekens, ...
Nature immunology 19 (7), 776-786, 2018
1142018
Candida albicans dampens host defense by downregulating IL-17 production
SC Cheng, F van de Veerdonk, S Smeekens, LAB Joosten, ...
The Journal of Immunology 185 (4), 2450-2457, 2010
1082010
Skin microbiome imbalance in patients with STAT1/STAT3 defects impairs innate host defense responses
SP Smeekens, C Huttenhower, A Riza, FL Van De Veerdonk, ...
Journal of innate immunity 6 (3), 253-262, 2014
1042014
Joosten LAB, Zhernakova A, Huttenhower C, Wijmenga C, Netea MG, Xavier RJ. Linking the human gut microbiome to inflammatory cytokine production capacity
M Schirmer, SP Smeekens, H Vlamakis, M Jaeger, M Oosting, ...
Cell 167 (4), 1125-1136, 2016
1012016
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