| Wnt/β-catenin signaling in development and disease H Clevers Cell 127 (3), 469-480, 2006 | 6722 | 2006 |
| Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche T Sato, RG Vries, HJ Snippert, M Van De Wetering, N Barker, DE Stange, ... Nature 459 (7244), 262-265, 2009 | 6298 | 2009 |
| Identification of stem cells in small intestine and colon by marker gene Lgr5 N Barker, JH Van Es, J Kuipers, P Kujala, M Van Den Born, M Cozijnsen, ... Nature 449 (7165), 1003-1007, 2007 | 5970 | 2007 |
| Wnt/β-catenin signaling and disease H Clevers, R Nusse Cell 149 (6), 1192-1205, 2012 | 5840 | 2012 |
| Activation of β-catenin-Tcf signaling in colon cancer by mutations in β-catenin or APC PJ Morin, AB Sparks, V Korinek, N Barker, H Clevers, B Vogelstein, ... Science 275 (5307), 1787-1790, 1997 | 5034 | 1997 |
| Wnt signalling in stem cells and cancer T Reya, H Clevers Nature 434 (7035), 843-850, 2005 | 4643 | 2005 |
| Constitutive transcriptional activation by a β-catenin-Tcf complex in APC−/− colon carcinoma V Korinek, N Barker, PJ Morin, D Van Wichen, R De Weger, KW Kinzler, ... Science 275 (5307), 1784-1787, 1997 | 4113 | 1997 |
| Wnt/β-catenin signaling, disease, and emerging therapeutic modalities R Nusse, H Clevers Cell 169 (6), 985-999, 2017 | 3314 | 2017 |
| Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett's epithelium T Sato, DE Stange, M Ferrante, RGJ Vries, JH Van Es, S Van Den Brink, ... Gastroenterology 141 (5), 1762-1772, 2011 | 3258 | 2011 |
| Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts T Sato, JH Van Es, HJ Snippert, DE Stange, RG Vries, M Van Den Born, ... Nature 469 (7330), 415-418, 2011 | 2616 | 2011 |
| The β-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells M Van de Wetering, E Sancho, C Verweij, W De Lau, I Oving, A Hurlstone, ... Cell 111 (2), 241-250, 2002 | 2487 | 2002 |
| Crypt stem cells as the cells-of-origin of intestinal cancer N Barker, RA Ridgway, JH Van Es, M Van De Wetering, H Begthel, ... Nature 457 (7229), 608-611, 2009 | 2366 | 2009 |
| XTcf-3 transcription factor mediates β-catenin-induced axis formation in Xenopus embryos M Molenaar, M Van De Wetering, M Oosterwegel, J Peterson-Maduro, ... Cell 86 (3), 391-399, 1996 | 2350 | 1996 |
| Modeling development and disease with organoids H Clevers Cell 165 (7), 1586-1597, 2016 | 2345 | 2016 |
| The cancer stem cell: premises, promises and challenges H Clevers Nature medicine 17 (3), 313-319, 2011 | 2199 | 2011 |
| Cancer stem cells revisited E Batlle, H Clevers Nature medicine 23 (10), 1124-1134, 2017 | 2163 | 2017 |
| Stem cells, self-renewal, and differentiation in the intestinal epithelium LG Van Der Flier, H Clevers Annual review of physiology 71, 241-260, 2009 | 2082 | 2009 |
| Linking colorectal cancer to Wnt signaling M Bienz, H Clevers Cell 103 (2), 311-320, 2000 | 2013 | 2000 |
| Caught up in a Wnt storm: Wnt signaling in cancer RH Giles, JH Van Es, H Clevers Biochimica et Biophysica Acta (BBA)-Reviews on Cancer 1653 (1), 1-24, 2003 | 2009 | 2003 |
| Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4 V Korinek, N Barker, P Moerer, E van Donselaar, G Huls, PJ Peters, ... Nature genetics 19 (4), 379-383, 1998 | 1982 | 1998 |
