Hans Clevers
Hans Clevers
Verified email at hubrecht.eu - Homepage
TitleCited byYear
Wnt/β-catenin signaling in development and disease
H Clevers
Cell 127 (3), 469-480, 2006
51862006
Activation of β-catenin-Tcf signaling in colon cancer by mutations in β-catenin or APC
PJ Morin, AB Sparks, V Korinek, N Barker, H Clevers, B Vogelstein, ...
Science 275 (5307), 1787-1790, 1997
43781997
Identification of stem cells in small intestine and colon by marker gene Lgr5
N Barker, JH Van Es, J Kuipers, P Kujala, M Van Den Born, M Cozijnsen, ...
Nature 449 (7165), 1003, 2007
40132007
Wnt signalling in stem cells and cancer
T Reya, H Clevers
Nature 434 (7035), 843, 2005
38852005
Wnt/β-catenin signaling and disease
H Clevers, R Nusse
Cell 149 (6), 1192-1205, 2012
36492012
Constitutive transcriptional activation by a β-catenin-Tcf complex in APC−/− colon carcinoma
V Korinek, N Barker, PJ Morin, D Van Wichen, R De Weger, KW Kinzler, ...
Science 275 (5307), 1784-1787, 1997
36061997
Single Lgr5 stem cells build crypt–villus structures in vitro without a mesenchymal niche
T Sato, RG Vries, HJ Snippert, M Van De Wetering, N Barker, DE Stange, ...
Nature 459 (7244), 262, 2009
30662009
The β-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells
M Van De Wetering, E Sancho, C Verweij, W De Lau, I Oving, A Hurlstone, ...
Cell 111 (2), 241-250, 2002
21512002
XTcf-3 transcription factor mediates β-catenin-induced axis formation in Xenopus embryos
M Molenaar, M van de Wetering, M Oosterwegel, J Peterson-Maduro, ...
Cell 86 (3), 391-399, 1996
19661996
Caught up in a Wnt storm: Wnt signaling in cancer
RH Giles, JH Van Es, H Clevers
Biochimica et Biophysica Acta (BBA)-Reviews on Cancer 1653 (1), 1-24, 2003
17772003
Crypt stem cells as the cells-of-origin of intestinal cancer
N Barker, RA Ridgway, JH van Es, M van de Wetering, H Begthel, ...
Nature 457 (7229), 608, 2009
17402009
Linking colorectal cancer to Wnt signaling
M Bienz, H Clevers
Cell 103 (2), 311-320, 2000
17292000
Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4
V Korinek, N Barker, P Moerer, E van Donselaar, G Huls, PJ Peters, ...
Nature genetics 19 (4), 379, 1998
17021998
Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts
T Sato, JH Van Es, HJ Snippert, DE Stange, RG Vries, M Van Den Born, ...
Nature 469 (7330), 415, 2011
15822011
The cancer stem cell: premises, promises and challenges
H Clevers
Nature medicine 17 (3), 313, 2011
15432011
Notch/γ-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells
JH van Es, ME van Gijn, O Riccio, M van den Born, M Vooijs, H Begthel, ...
Nature 435 (7044), 959, 2005
14362005
Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation
DA Glass II, P Bialek, JD Ahn, M Starbuck, MS Patel, H Clevers, ...
Developmental cell 8 (5), 751-764, 2005
13352005
Armadillo coactivates transcription driven by the product of the Drosophila segment polarity gene dTCF
M Van de Wetering, R Cavallo, D Dooijes, M van Beest, J van Es, ...
Cell 88 (6), 789-799, 1997
13061997
Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett's epithelium
T Sato, DE Stange, M Ferrante, RGJ Vries, JH Van Es, S Van Den Brink, ...
Gastroenterology 141 (5), 1762-1772, 2011
12982011
Stem cells, self-renewal, and differentiation in the intestinal epithelium
LG Van Der Flier, H Clevers
Annual review of physiology 71, 241-260, 2009
12732009
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Articles 1–20