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Alex de Bruin
Alex de Bruin
Scientist, Janssen Pharmaceuticals
Geverifieerd e-mailadres voor its.jnj.com
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Chronic IFN-γ production in mice induces anemia by reducing erythrocyte life span and inhibiting erythropoiesis through an IRF-1/PU. 1 axis
SF Libregts, L Gutiérrez, AM de Bruin, FM Wensveen, P Papadopoulos, ...
Blood, The Journal of the American Society of Hematology 118 (9), 2578-2588, 2011
2402011
Interferon-γ impairs proliferation of hematopoietic stem cells in mice
AM de Bruin, Ö Demirel, B Hooibrink, CH Brandts, MA Nolte
Blood, The Journal of the American Society of Hematology 121 (18), 3578-3585, 2013
2342013
Impact of interferon-γ on hematopoiesis
AM de Bruin, C Voermans, MA Nolte
Blood, The Journal of the American Society of Hematology 124 (16), 2479-2486, 2014
1992014
Eosinophil differentiation in the bone marrow is inhibited by T cell–derived IFN-γ
AM de Bruin, M Buitenhuis, KF van der Sluijs, KPJM van Gisbergen, ...
Blood, The Journal of the American Society of Hematology 116 (14), 2559-2569, 2010
752010
Erythropoietin accelerates smooth muscle cell–rich vascular lesion formation in mice through endothelial cell activation involving enhanced PDGF-BB release
ML Janmaat, JLT Heerkens, AM de Bruin, A Klous, V de Waard, ...
Blood, The Journal of the American Society of Hematology 115 (7), 1453-1460, 2010
732010
Activating mutations in c-KIT and PDGFRα are exclusively found in gastrointestinal stromal tumors and not in other tumors overexpressing these imatinib mesylate target genes
K Burger, MA den Bakker, JM Kros, AM de Bruin, W Oosterhuis, ...
Cancer biology & therapy 4 (11), 1270-1274, 2005
652005
Aberrantly expressed LGR4 empowers Wnt signaling in multiple myeloma by hijacking osteoblast-derived R-spondins
H Van Andel, Z Ren, I Koopmans, SPJ Joosten, KA Kocemba, W De Lau, ...
Proceedings of the National Academy of Sciences 114 (2), 376-381, 2017
432017
BH3-only protein Noxa regulates apoptosis in activated B cells and controls high-affinity antibody formation
FM Wensveen, IAM Derks, KPJM Van Gisbergen, AM De Bruin, ...
Blood, The Journal of the American Society of Hematology 119 (6), 1440-1449, 2012
392012
Continuous CD27 triggering in vivo strongly reduces NK cell numbers
V De Colvenaer, S Taveirne, J Hamann, AM de Bruin, M De Smedt, ...
European journal of immunology 40 (4), 1107-1117, 2010
322010
The DNA damage response regulates RAG1/2 expression in pre–B cells through ATM-FOXO1 signaling
K Ochodnicka-Mackovicova, M Bahjat, C Maas, A Van Der Veen, ...
The Journal of Immunology 197 (7), 2918-2929, 2016
302016
NF-κB and AKT signaling prevent DNA damage in transformed pre-B cells by suppressing RAG1/2 expression and activity
K Ochodnicka-Mackovicova, M Bahjat, TA Bloedjes, C Maas, AM de Bruin, ...
Blood, The Journal of the American Society of Hematology 126 (11), 1324-1335, 2015
252015
A novel role for CD55 in granulocyte homeostasis and anti-bacterial host defense
H Veninga, RM Hoek, AF de Vos, AM de Bruin, FQ An, T van der Poll, ...
PLoS One 6 (10), e24431, 2011
222011
CD70-driven chronic immune activation is protective against atherosclerosis
RW Van Olffen, AM De Bruin, M Vos, AD Staniszewska, J Hamann, ...
Journal of innate immunity 2 (4), 344-352, 2010
212010
In vivo knockdown of TAK1 accelerates bone marrow proliferation/differentiation and induces systemic inflammation
PM Vink, WM Smout, LJ Driessen-Engels, AM de Bruin, D Delsing, ...
PloS one 8 (3), e57348, 2013
122013
Interferon-gamma induces monopoiesis and inhibits neutrophil development during inflammation
AM de Bruin, MG Valkhof, L Boon, IP Touw, MA Nolte
Blood, The Journal of the American Society of Hematology 118 (21), 1320-1320, 2011
32011
in mice induces anemia by reducing erythrocyte lifespan and inhibiting erythropoiesis through an IRF-1/PU. 1-axis
SF Libregts, L Gutiérrez, AM de Bruin, FM Wensveen, P Papadopoulos, ...
Immune activation and lineage fate decisions: Inducing a shift of program …, 2011
2011
CD55 regulates CD97 expression, granulopoietic activity, and anti-bacterial host defense
H Veninga, RM Hoek, AF de Vos, AM de Bruin, D Flierman, FQ An, ...
In vivo studies on the role of Adhesion-GPCR CD97 in immunity, 77, 2010
2010
CHAPTER VI CHAPTER VI
FM Wensveen, IAM Derks, AM de Bruin, KPJM van Gisbergen, MA Nolte, ...
Survival of the fittest clone: Pro-apoptotic protein Noxa controls selection …, 0
BH3-only protein Noxa plays a role in the regulation of early erythropoiesis
FM Wensveen, CR Geest, SFWM Libregts, AM de Bruin, IAM Derks, ...
Survival of the fittest clone: Pro-apoptotic protein Noxa controls selection …, 0
function during ontogeny of the hematopoietic system
SF Libregts, C Orelio, N Legrand, AM de Bruin, S Klamer, C Voermans, ...
Immune activation and lineage fate decisions: Inducing a shift of program, 55, 0
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Artikelen 1–20