| SB1518, a novel macrocyclic pyrimidine-based JAK2 inhibitor for the treatment of myeloid and lymphoid malignancies S Hart, KC Goh, V Novotny-Diermayr, CY Hu, H Hentze, YC Tan, B Madan, ... Leukemia 25 (11), 1751-1759, 2011 | 208 | 2011 |
| Discovery of the Macrocycle 11-(2-Pyrrolidin-1-yl-ethoxy)-14, 19-dioxa-5, 7, 26-triaza-tetracyclo [19.3. 1.1 (2, 6). 1 (8, 12)] heptacosa-1 (25), 2 (26), 3, 5, 8, 10, 12 (27 … AD William, ACH Lee, S Blanchard, A Poulsen, EL Teo, H Nagaraj, E Tan, ... Journal of medicinal chemistry 54 (13), 4638-4658, 2011 | 196 | 2011 |
| Recent advances in the synthetic chemistry of bicyclo [1.1. 1] pentane J Kanazawa, M Uchiyama Synlett 30 (01), 1-11, 2019 | 132 | 2019 |
| TG02, a novel oral multi-kinase inhibitor of CDKs, JAK2 and FLT3 with potent anti-leukemic properties KC Goh, V Novotny-Diermayr, S Hart, LC Ong, YK Loh, A Cheong, ... Leukemia 26 (2), 236-243, 2012 | 129 | 2012 |
| Discovery of Kinase Spectrum Selective Macrocycle (16E)-14-Methyl-20-oxa-5,7,14,26-tetraazatetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8(27),9 … AD William, ACH Lee, KC Goh, S Blanchard, A Poulsen, EL Teo, ... Journal of medicinal chemistry 55 (1), 169-196, 2012 | 97 | 2012 |
| Synthesis of tetrahydrocannabinols based on an indirect 1, 4-addition strategy AD William, Y Kobayashi The Journal of organic chemistry 67 (25), 8771-8782, 2002 | 84 | 2002 |
| Sharpless asymmetric dihydroxylation of trans-propenylphosphonate by using a modified AD-mix-α and the synthesis of fosfomycin Y Kobayashi, AD William, Y Tokoro The Journal of organic chemistry 23 (66), 7903-7906, 2001 | 55 | 2001 |
| Structure-based design of oxygen-linked macrocyclic kinase inhibitors: discovery of SB1518 and SB1578, potent inhibitors of Janus kinase 2 (JAK2) and Fms-like tyrosine kinase-3 … A Poulsen, A William, S Blanchard, A Lee, H Nagaraj, H Wang, E Teo, ... Journal of computer-aided molecular design 26 (4), 437-450, 2012 | 53 | 2012 |
| Discovery of the Macrocycle (9E)-15-(2-(Pyrrolidin-1-yl)ethoxy)-7,12,25-trioxa-19,21,24-triaza-tetracyclo[18.3.1.1(2,5).1(14,18)]hexacosa-1(24),2,4,9,14(26),15,17 … AD William, ACH Lee, A Poulsen, KC Goh, B Madan, S Hart, E Tan, ... Journal of medicinal chemistry 55 (6), 2623-2640, 2012 | 51 | 2012 |
| Palladium‐and Nickel‐Catalyzed Coupling Reactions of α‐Bromoalkenylphosphonates with Arylboronic Acids and Lithium Alkenylborates Y Kobayashi, AD William Advanced Synthesis & Catalysis 346 (13‐15), 1749-1757, 2004 | 49 | 2004 |
| A New Route to Bicyclo [1.1. 1] pentan-1-amine from 1-Azido-3-iodobicyclo [1.1. 1] pentane YL Goh, EKW Tam, PH Bernardo, CB Cheong, CW Johannes, AD William, ... Organic letters 16 (7), 1884-1887, 2014 | 48 | 2014 |
| Structure-based design of nitrogen-linked macrocyclic kinase inhibitors leading to the clinical candidate SB1317/TG02, a potent inhibitor of cyclin dependant kinases (CDKs … A Poulsen, A William, S Blanchard, H Nagaraj, M Williams, H Wang, ... Journal of molecular modeling 19, 119-130, 2013 | 47 | 2013 |
| Luminescence-based methods and probes for measuring cytochrome P450 activity JJ Cali, D Klaubert, W Daily, SKS Ho, S Frackman, E Hawkins, KV Wood US Patent 7,692,022, 2010 | 45 | 2010 |
| Coupling reactions of α-bromoalkenyl phosphonates with aryl boronic acids and alkenyl borates Y Kobayashi, AD William Organic Letters 4 (24), 4241-4244, 2002 | 44 | 2002 |
| Scope and limitation of the nickel-catalyzed coupling reaction between lithium borates and mesylates Y Kobayashi, AD William, R Mizojiri Journal of organometallic chemistry 653 (1-2), 91-97, 2002 | 44 | 2002 |
| A method to accomplish a 1, 4-addition reaction of bulky nucleophiles to enones and subsequent formation of reactive enolates AD William, Y Kobayashi Organic Letters 3 (13), 2017-2020, 2001 | 41 | 2001 |
| SB1578, a novel inhibitor of JAK2, FLT3, and c-Fms for the treatment of rheumatoid arthritis B Madan, KC Goh, S Hart, AD William, R Jayaraman, K Ethirajulu, ... The Journal of Immunology 189 (8), 4123-4134, 2012 | 36 | 2012 |
| Synthesis and evaluation of alkenyl indazoles as selective Aurora kinase inhibitors S Blanchard, AD William, ACH Lee, A Poulsen, EL Teo, W Deng, N Tu, ... Bioorganic & Medicinal Chemistry Letters 20 (8), 2443-2447, 2010 | 21 | 2010 |
| Teacher Self-Appraisal, Ohio: Charles, A MB Allen, D William, L Gerald, EW Robexon Jones Publishing Co., Washington, 1970 | 21 | 1970 |
| Structure-based optimization of morpholino-triazines as PI3K and mTOR inhibitors A Poulsen, M Williams, HM Nagaraj, AD William, H Wang, CK Soh, ... Bioorganic & medicinal chemistry letters 22 (2), 1009-1013, 2012 | 20 | 2012 |
