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Severe deficiency of the voltage-gated sodium channel NaV1. 2 elevates neuronal excitability in adult mice
J Zhang, X Chen, M Eaton, J Wu, Z Ma, S Lai, A Park, TS Ahmad, Z Que, ...
Cell reports 36 (5), 2021
442021
Hyperexcitability and pharmacological responsiveness of cortical neurons derived from human iPSCs carrying epilepsy-associated sodium channel Nav1. 2-L1342P genetic variant
Z Que, MI Olivero-Acosta, J Zhang, M Eaton, AM Tukker, X Chen, J Wu, ...
Journal of Neuroscience 41 (49), 10194-10208, 2021
292021
Generation and basic characterization of a gene‐trap knockout mouse model of Scn2a with a substantial reduction of voltage‐gated sodium channel Nav1.2 …
M Eaton, J Zhang, Z Ma, AC Park, E Lietzke, CM Romero, Y Liu, ...
Genes, Brain and Behavior 20 (4), e12725, 2021
182021
Deficiency of autism-related Scn2a gene in mice disrupts sleep patterns and circadian rhythms
Z Ma, M Eaton, Y Liu, J Zhang, X Chen, X Tu, Y Shi, Z Que, ...
Neurobiology of disease 168, 105690, 2022
162022
Multi-Electrode Array of Sensory Neurons as an In Vitro Platform to Identify the Nociceptive Response to Pharmaceutical Buffer Systems of Injectable Biologics
M Eaton, Z Que, J Zhang, K Beck, R Shi, J McDermott, M Ladisch, Y Yang
Pharmaceutical Research 38, 1179-1186, 2021
32021
Microglial over-pruning of synapses during development in autism-associated SCN2A-deficient mice and human cerebral organoids
J Wu, J Zhang, X Chen, K Wettschurack, Z Que, BA Deming, ...
Molecular Psychiatry, 1-14, 2024
22024
Sodium channel Nav1. 2-L1342P variant displaying complex biophysical properties renders hyperexcitability of cortical neurons derived from human iPSCs
Z Que, MI Olivero-Acosta, J Zhang, M Eaton, WC Skarnes, Y Yang
BioRxiv, 2021.01. 18.427192, 2021
22021
Human iPSC-derived microglia sense and dampen hyperexcitability of cortical neurons carrying the epilepsy-associated SCN2A-L1342P mutation
Z Que, MI Olivero-Acosta, I Chen, J Zhang, K Wettschurack, J Wu, T Xiao, ...
bioRxiv, 2023
2023
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