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Ioannis N Melas
Ioannis N Melas
Shell, Data Science Contractor
Verified email at shell.com
Title
Cited by
Cited by
Year
Identifying drug effects via pathway alterations using an integer linear programming optimization formulation on phosphoproteomic data
A Mitsos, IN Melas, P Siminelakis, AD Chairakaki, J Saez-Rodriguez, ...
PLoS computational biology 5 (12), e1000591, 2009
1552009
Identifying drug effects via pathway alterations using an integer linear programming optimization formulation on phosphoproteomic data
A Mitsos, IN Melas, P Siminelakis, AD Chairakaki, J Saez-Rodriguez, ...
PLoS computational biology 5 (12), e1000591, 2009
1552009
Rheumatoid arthritis patients display B-cell dysregulation already in the naïve repertoire consistent with defects in B-cell tolerance
Y Wang, KA Lloyd, I Melas, D Zhou, R Thyagarajan, J Lindqvist, ...
Scientific reports 9 (1), 19995, 2019
732019
The species translation challenge—a systems biology perspective on human and rat bronchial epithelial cells
C Poussin, C Mathis, LG Alexopoulos, DE Messinis, RHJ Dulize, ...
Scientific Data 1 (1), 1-14, 2014
512014
Identification of drug-specific pathways based on gene expression data: application to drug induced lung injury
IN Melas, T Sakellaropoulos, F Iorio, LG Alexopoulos, WY Loh, ...
Integrative biology 7 (8), 904-920, 2015
492015
Detecting and removing inconsistencies between experimental data and signaling network topologies using integer linear programming on interaction graphs
IN Melas, R Samaga, LG Alexopoulos, S Klamt
PLoS computational biology 9 (9), e1003204, 2013
462013
Modeling of signaling pathways in chondrocytes based on phosphoproteomic and cytokine release data
IN Melas, AD Chairakaki, EI Chatzopoulou, DE Messinis, T Katopodi, ...
Osteoarthritis and Cartilage 22 (3), 509-518, 2014
402014
Phosphoproteomics in drug discovery
MK Morris, A Chi, IN Melas, LG Alexopoulos
Drug discovery today 19 (4), 425-432, 2014
362014
Combined logical and data-driven models for linking signalling pathways to cellular response
IN Melas, A Mitsos, DE Messinis, TS Weiss, LG Alexopoulos
BMC systems biology 5, 1-12, 2011
342011
Signaling networks in MS: a systems-based approach to developing new pharmacological therapies
E Kotelnikova, M Bernardo-Faura, G Silberberg, NA Kiani, D Messinis, ...
Multiple Sclerosis Journal 21 (2), 138-146, 2015
302015
Non Linear Programming (NLP) formulation for quantitative modeling of protein signal transduction pathways
A Mitsos, IN Melas, MK Morris, J Saez-Rodriguez, DA Lauffenburger, ...
PLoS One 7 (11), e50085, 2012
212012
Construction of large signaling pathways using an adaptive perturbation approach with phosphoproteomic data
IN Melas, A Mitsos, DE Messinis, TS Weiss, JS Rodriguez, ...
Molecular Biosystems 8 (5), 1571-1584, 2012
162012
Translational systems pharmacology‐based predictive assessment of drug‐induced cardiomyopathy
DE Messinis, IN Melas, J Hur, N Varshney, LG Alexopoulos, JPF Bai
CPT: Pharmacometrics & Systems Pharmacology 7 (3), 166-174, 2018
142018
A crowd-sourcing approach for the construction of species-specific cell signaling networks
E Bilal, T Sakellaropoulos, C Participants, IN Melas, DE Messinis, ...
Bioinformatics 31 (4), 484-491, 2014
132014
Construction of Cell Type-Specific Logic Models of Signaling Networks Using CellNOpt
MK Morris, I Melas, J Saez-Rodriguez
Computational Toxicology: Volume II, 179-214, 2013
132013
Advances in omics for informed pharmaceutical research and development in the era of systems medicine
JPF Bai, IN Melas, J Hur, E Guo
Expert opinion on drug discovery 13 (1), 1-4, 2018
102018
Leveraging systems biology approaches in clinical pharmacology
IN Melas, K Kretsos, LG Alexopoulos
Biopharmaceutics & drug disposition 34 (9), 477-488, 2013
82013
Construction of signaling pathways and identification of drug effects on the liver cancer cell HepG2
LG Alexopoulos, IN Melas, AD Chairakaki, J Saez-Rodriguez, A Mitsos
2010 Annual International Conference of the IEEE Engineering in Medicine and …, 2010
82010
Identification of drug-specific pathways based on gene expression data: application to drug induced lung injury. Integr Biol
IN Melas, T Sakellaropoulos, F Iorio, LG Alexopoulos, WY Loh, ...
Royal Society of Chemistry, 2015
72015
Network‐based analysis of nutraceuticals in human hepatocellular carcinomas reveals mechanisms of chemopreventive action
M Michailidou, IN Melas, DE Messinis, S Klamt, LG Alexopoulos, ...
CPT: pharmacometrics & systems pharmacology 4 (6), 350-361, 2015
72015
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Articles 1–20