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Ralph Pantophlet
Ralph Pantophlet
Associate Professor, Simon Fraser University
Geverifieerd e-mailadres voor sfu.ca - Homepage
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Crystal structure of a neutralizing human IGG against HIV-1: a template for vaccine design
EO Saphire, PWHI Parren, R Pantophlet, MB Zwick, GM Morris, PM Rudd, ...
science 293 (5532), 1155-1159, 2001
11092001
The broadly neutralizing anti-human immunodeficiency virus type 1 antibody 2G12 recognizes a cluster of α1→ 2 mannose residues on the outer face of gp120
CN Scanlan, R Pantophlet, MR Wormald, E Ollmann Saphire, R Stanfield, ...
Journal of virology 76 (14), 7306-7321, 2002
8622002
GP120: target for neutralizing HIV-1 antibodies
R Pantophlet, DR Burton
Annu. Rev. Immunol. 24, 739-769, 2006
6072006
Fine mapping of the interaction of neutralizing and nonneutralizing monoclonal antibodies with the CD4 binding site of human immunodeficiency virus type 1 gp120
R Pantophlet, E Ollmann Saphire, P Poignard, PWHI Parren, IA Wilson, ...
Journal of virology 77 (1), 642-658, 2003
3132003
Dissecting the neutralizing antibody specificities of broadly neutralizing sera from human immunodeficiency virus type 1-infected donors
AK Dhillon, H Donners, R Pantophlet, WE Johnson, JM Decker, GM Shaw, ...
Journal of virology 81 (12), 6548-6562, 2007
2452007
Differential Roles of CD14 and Toll-like Receptors 4and 2 in Murine Acinetobacter Pneumonia
S Knapp, CW Wieland, S Florquin, R Pantophlet, L Dijkshoorn, ...
American journal of respiratory and critical care medicine 173 (1), 122-129, 2006
2402006
Hyperglycosylated mutants of human immunodeficiency virus (HIV) type 1 monomeric gp120 as novel antigens for HIV vaccine design
R Pantophlet, IA Wilson, DR Burton
Journal of virology 77 (10), 5889-5901, 2003
1802003
A glycoconjugate antigen based on the recognition motif of a broadly neutralizing human immunodeficiency virus antibody, 2G12, is immunogenic but elicits antibodies unable to …
RD Astronomo, HK Lee, CN Scanlan, R Pantophlet, CY Huang, IA Wilson, ...
Journal of virology 82 (13), 6359-6368, 2008
1482008
Defining criteria for oligomannose immunogens for HIV using icosahedral virus capsid scaffolds
RD Astronomo, E Kaltgrad, AK Udit, SK Wang, KJ Doores, CY Huang, ...
Chemistry & biology 17 (4), 357-370, 2010
1412010
Comparing antigenicity and immunogenicity of engineered gp120
S Selvarajah, B Puffer, R Pantophlet, M Law, RW Doms, DR Burton
Journal of virology 79 (19), 12148-12163, 2005
1202005
A Dominant Role for CD8+-T-Lymphocyte Selection in Simian Immunodeficiency Virus Sequence Variation
DH O'Connor, AB McDermott, KC Krebs, EJ Dodds, JE Miller, ...
Journal of virology 78 (24), 14012-14022, 2004
1142004
Structure of antibody F425-B4e8 in complex with a V3 peptide reveals a new binding mode for HIV-1 neutralization
CH Bell, R Pantophlet, A Schiefner, LA Cavacini, RL Stanfield, DR Burton, ...
Journal of molecular biology 375 (4), 969-978, 2008
992008
Mode of action for linear peptide inhibitors of HIV-1 gp120 interactions
AC Biorn, S Cocklin, N Madani, Z Si, T Ivanovic, J Samanen, DI Van Ryk, ...
Biochemistry 43 (7), 1928-1938, 2004
872004
Reduced magnitude and durability of humoral immune responses to COVID-19 mRNA vaccines among older adults
MA Brockman, F Mwimanzi, HR Lapointe, Y Sang, O Agafitei, PK Cheung, ...
The Journal of Infectious Diseases 225 (7), 1129-1140, 2022
862022
Improved design of an antigen with enhanced specificity for the broadly HIV-neutralizing antibody b12
R Pantophlet, IA Wilson, DR Burton
Protein Engineering Design and Selection 17 (10), 749-758, 2004
822004
Analysis of the neutralization breadth of the anti-V3 antibody F425-B4e8 and re-assessment of its epitope fine specificity by scanning mutagenesis
R Pantophlet, RO Aguilar-Sino, T Wrin, LA Cavacini, DR Burton
Virology 364 (2), 441-453, 2007
812007
Structure of a high-affinity “mimotope” peptide bound to HIV-1-neutralizing antibody b12 explains its inability to elicit gp120 cross-reactive antibodies
EO Saphire, M Montero, A Menendez, NE van Houten, MB Irving, ...
Journal of molecular biology 369 (3), 696-709, 2007
762007
Humoral immune responses to COVID-19 vaccination in people living with HIV receiving suppressive antiretroviral therapy
ZL Brumme, F Mwimanzi, HR Lapointe, PK Cheung, Y Sang, MC Duncan, ...
npj Vaccines 7 (1), 28, 2022
732022
Binding of the mannose-specific lectin, griffithsin, to HIV-1 gp120 exposes the CD4-binding site
KB Alexandre, ES Gray, R Pantophlet, PL Moore, JB McMahon, ...
Journal of virology 85 (17), 9039-9050, 2011
732011
The carbohydrate epitope of the neutralizing anti-HIV-1 antibody 2G12
CN Scanlan, R Pantophlet, MR Wormald, EO Saphire, D Calarese, ...
Glycobiology and Medicine, 205-218, 2003
722003
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