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Marcella Brescia
Marcella Brescia
Leiden University Medical Center
Geverifieerd e-mailadres voor lumc.nl
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FRET biosensor uncovers cAMP nano-domains at β-adrenergic targets that dictate precise tuning of cardiac contractility
NC Surdo, M Berrera, A Koschinski, M Brescia, MR Machado, C Carr, ...
Nature communications 8 (1), 15031, 2017
1902017
An essential cell-autonomous role for hepcidin in cardiac iron homeostasis
S Lakhal-Littleton, M Wolna, YJ Chung, HC Christian, LC Heather, ...
Elife 5, e19804, 2016
1782016
Modulation of compartmentalised cyclic nucleotide signalling via local inhibition of phosphodiesterase activity
M Brescia, M Zaccolo
International journal of molecular sciences 17 (10), 1672, 2016
592016
Expanding the editable genome and CRISPR–Cas9 versatility using DNA cutting-free gene targeting based on in trans paired nicking
X Chen, F Tasca, Q Wang, J Liu, JM Janssen, MD Brescia, M Bellin, ...
Nucleic Acids Research 48 (2), 974-995, 2020
292020
High-Capacity Adenoviral Vectors Permit Robust and Versatile Testing of DMD Gene Repair Tools and Strategies in Human Cells
M Brescia, JM Janssen, J Liu, MAFV Gonçalves
Cells 9 (4), 869, 2020
232020
Phosphodiesterase 2A as a therapeutic target to restore cardiac neurotransmission during sympathetic hyperactivity
K Liu, D Li, G Hao, D McCaffary, O Neely, L Woodward, D Ioannides, ...
JCI insight 3 (9), 2018
232018
Adenoviral transduction of FRET-based biosensors for cAMP in primary adult mouse cardiomyocytes
O Lomas, M Brescia, R Carnicer, S Monterisi, NC Surdo, M Zaccolo
cAMP Signaling: Methods and Protocols, 103-115, 2015
142015
FRET biosensor uncovers cAMP nano-domains at β-adrenergic targets that dictate precise tuning of cardiac contractility. Nat Commun 8: 15031
NC Surdo, M Berrera, A Koschinski, M Brescia, MR Machado, C Carr, ...
132017
Large-scale genome editing based on high-capacity adenovectors and CRISPR-Cas9 nucleases rescues full-length dystrophin synthesis in DMD muscle cells
F Tasca, M Brescia, Q Wang, J Liu, JM Janssen, K Szuhai, ...
Nucleic Acids Research 50 (13), 7761-7782, 2022
112022
Vascularized hiPSC-derived 3D cardiac microtissue on chip
U Arslan, M Brescia, V Meraviglia, DM Nahon, RWJ van Helden, JM Stein, ...
Stem cell reports 18 (7), 1394-1404, 2023
92023
Multi-Compartment, Early Disruption of cGMP and cAMP Signalling in Cardiac Myocytes from the mdx Model of Duchenne Muscular Dystrophy
M Brescia, YC Chao, A Koschinski, J Tomek, M Zaccolo
International Journal of Molecular Sciences 21 (19), 7056, 2020
92020
Increase in Ca2+ current by sustained cAMP levels enhances proliferation rate in GH3 cells
AL Rodrigues, M Brescia, A Koschinski, TH Moreira, RT Cameron, ...
Life sciences 192, 144-150, 2018
92018
An essential cell-autonomous role for hepcidin in cardiac iron homeostasis. Elife 5
S Lakhal-Littleton, M Wolna, YJ Chung, HC Christian, LC Heather, ...
92016
High-capacity adenovector delivery of forced CRISPR-Cas9 heterodimers fosters precise chromosomal deletions in human cells
F Tasca, M Brescia, J Liu, JM Janssen, K Mamchaoui, MAFV Gonçalves
Molecular Therapy-Nucleic Acids 31, 746-762, 2023
32023
ETV2 upregulation marks the specification of early cardiomyocytes and endothelial cells during co-differentiation
X Cao, M Mircea, GK Yakala, FE van den Hil, M Brescia, H Mei, ...
Stem Cells 41 (2), 140-152, 2023
22023
Increasing efficiency of alveolar type II cells generation from human induced pluripotent stem cells
AR Ruiz, A Ravi, S Khoenkhoen, MD Brescia, B Van Meer, R Olmer, ...
European Respiratory Journal 60 (suppl 66), 2022
2022
Multi-compartment, early disruption of cGMP and cAMP signalling in cardiac myocytes from the mdx model of Duchenne Muscular Dystrophy
M Brescia, YC Chao, A Koschinski, J Tomek, M Zaccolo
International Journal of Molecular Sciences 21 (19), 2020
2020
Increase in Ca2+ current by sustained cAMP levels enhances proliferation rate in GH3 cells
M Brescia, A Koschinski, RT Cameron, G Baillie, M Zaccolo, JS Cruz
Life sciences 192 (2), 2018
2018
204 The cardiac hepcidin/ferroportin axis is essntial for cardiac iron homeostasis and function
S Lakhal-Littleton, M Wolna, YJ Chung, H Christian, L Heather, M Brescia, ...
Heart 103 (Suppl 5), A137-A137, 2017
2017
Cyclic nucleotide signalling in cardiac myocytes from the mdx model of Duchenne muscular dystrophy
M Brescia
University of Oxford, 2017
2017
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