| RNA motif discovery by SHAPE and mutational profiling (SHAPE-MaP) NA Siegfried, S Busan, GM Rice, JAE Nelson, KM Weeks Nature methods 11 (9), 959-965, 2014 | 614 | 2014 |
| Selective 2′-hydroxyl acylation analyzed by primer extension and mutational profiling (SHAPE-MaP) for direct, versatile and accurate RNA structure analysis MJ Smola, GM Rice, S Busan, NA Siegfried, KM Weeks Nature protocols 10 (11), 1643-1669, 2015 | 336 | 2015 |
| Mechanistic characterization of the HDV genomic ribozyme: solvent isotope effects and proton inventories in the absence of divalent metal ions support C75 as the general acid AL Cerrone-Szakal, NA Siegfried, PC Bevilacqua Journal of the American Chemical Society 130 (44), 14504-14520, 2008 | 64 | 2008 |
| The genetic code as expressed through relationships between mRNA structure and protein function DM Mauger, NA Siegfried, KM Weeks FEBS letters 587 (8), 1180-1188, 2013 | 62 | 2013 |
| Driving Forces for Nucleic Acid pKa Shifting in an A+·C Wobble: Effects of Helix Position, Temperature, and Ionic Strength NA Siegfried, B O’Hare, PC Bevilacqua Biochemistry 49 (15), 3225-3236, 2010 | 51 | 2010 |
| Folding cooperativity in RNA and DNA is dependent on position in the helix NA Siegfried, SL Metzger, PC Bevilacqua Biochemistry 46 (1), 172-181, 2007 | 51 | 2007 |
| Role of unsatisfied hydrogen bond acceptors in RNA energetics and specificity NA Siegfried, R Kierzek, PC Bevilacqua Journal of the American Chemical Society 132 (15), 5342-5344, 2010 | 35 | 2010 |
| Selective 2′-hydroxyl acylation analyzed by protection from exoribonuclease (RNase-detected SHAPE) for direct analysis of covalent adducts and of nucleotide flexibility in RNA KA Steen, NA Siegfried, KM Weeks Nature protocols 6 (11), 1683-1694, 2011 | 30 | 2011 |
| Thinking inside the box: designing, implementing, and interpreting thermodynamic cycles to dissect cooperativity in RNA and DNA folding NA Siegfried, PC Bevilacqua Methods in enzymology 455, 365-393, 2009 | 26 | 2009 |
| Use of ice-nucleating proteins to improve the performance of freeze–thaw valves in microfluidic devices JC Gaiteri, WH Henley, NA Siegfried, TH Linz, JM Ramsey Analytical chemistry 89 (11), 5998-6005, 2017 | 14 | 2017 |
| Spatially isolated reactions in a complex array: using magnetic beads to purify and quantify nucleic acids with digital and quantitative real-time PCR in thousands of parallel … WH Henley, NA Siegfried, JM Ramsey Lab on a Chip 20 (10), 1771-1779, 2020 | 10 | 2020 |
| Mechanistic analysis of the hepatitis delta virus (HDV) ribozyme: methods for RNA preparation, structure mapping, solvent isotope effects, and co-transcriptional cleavage DM Chadalavada, AL Cerrone-Szakal, JL Wilcox, NA Siegfried, ... Ribozymes: Methods and Protocols, 21-40, 2012 | 9 | 2012 |
| Synthesis of 1-methyl-7-nitroisatoic anhydride (1M7) KM Weeks, KA Steen, NA Siegfried | 8 | 2011 |
| Insight into the functional versatility of RNA through model-making with applications to data fitting PC Bevilacqua, AL Cerrone-Szakal, NA Siegfried Quarterly Reviews of Biophysics 40 (1), 55-85, 2007 | 6 | 2007 |
| Detection of chemical modifications in nucleic acids KM Weeks, N Siegfried, P Homan, S Busan, OV Favorov US Patent 10,240,188, 2019 | 1 | 2019 |
| Folding Cooperativity and Its Influence on pKa Shifting in Nucleic Acids NA Siegfried | 1 | 2009 |
| Folding cooperativity dictates extent of pKa shifting in RNA and DNA NA Siegfried, SL Metzger, PC Bevilacqua ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 233, 2007 | | 2007 |
| General acid-base catalysis and pKa shifting in RNA: Insights from ribozymes and model oligonucleotides PC Bevilacqua, TS Brown, DM Chadalavada, JT Lecomte, EM Moody, ... ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 233, 2007 | | 2007 |
| Mechanistic studies of nicotinamide coenzyme model reactions. MK Schlegel, RD Libby, RM Koralewski, NA Siegfried ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 227, U436-U436, 2004 | | 2004 |
| Supplementary Information for NA Siegfried, S Busan, GM Rice, JAE Nelson, KM Weeks | | |
Philip BevilacquaProfessor of Chemistry, The Pennsylvania State UniversityVerified email at psu.edu
