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Alessandra Silvestri
Alessandra Silvestri
FONDAZIONE HUMAN TECHNOPOLE
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SIGNOR: a database of causal relationships between biological entities
L Perfetto, L Briganti, A Calderone, A Cerquone Perpetuini, M Iannuccelli, ...
Nucleic acids research 44 (D1), D548-D554, 2016
2462016
Laser capture microdissection and protein microarray analysis of human non-small cell lung cancer: differential epidermal growth factor receptor (EGPR) phosphorylation events …
AJ VanMeter, AS Rodriguez, ED Bowman, J Jen, CC Harris, J Deng, ...
Molecular & Cellular Proteomics 7 (10), 1902-1924, 2008
1362008
Deep proteomics of breast cancer cells reveals that metformin rewires signaling networks away from a pro-growth state
F Sacco, A Silvestri, D Posca, S Pirrò, PF Gherardini, L Castagnoli, ...
Cell systems 2 (3), 159-171, 2016
872016
Protein pathway biomarker analysis of human cancer reveals requirement for upfront cellular-enrichment processing
A Silvestri, A Colombatti, VS Calvert, J Deng, E Mammano, C Belluco, ...
Laboratory investigation 90 (5), 787-796, 2010
722010
Heterogeneous pathway activation and drug response modelled in colorectal-tumor-derived 3D cultures
D Schumacher, G Andrieux, K Boehnke, M Keil, A Silvestri, M Silvestrov, ...
PLOS Genetics 15 (3), e1008076, 2019
702019
Metformin induces apoptosis and downregulates pyruvate kinase M2 in breast cancer cells only when grown in nutrient-poor conditions
A Silvestri, F Palumbo, I Rasi, D Posca, T Pavlidou, S Paoluzi, ...
PloS one 10 (8), e0136250, 2015
492015
Individualized therapy for metastatic colorectal cancer
A Silvestri, E Pin, A Huijbers, R Pellicani, EM Parasido, M Pierobon, ...
Journal of internal medicine 274 (1), 1-24, 2013
432013
Three-Dimensional Patient-Derived In Vitro Sarcoma Models: Promising Tools for Improving Clinical Tumor Management
M Gaebler, A Silvestri, J Haybaeck, P Reichardt, CD Lowery, LF Stancato, ...
Frontiers in Oncology 7, 203, 2017
422017
The solution structure of EMILIN1 globular C1q domain reveals a disordered insertion necessary for interaction with the α4β1 integrin
G Verdone, R Doliana, A Corazza, SA Colebrooke, P Spessotto, S Bot, ...
Journal of Biological Chemistry 283 (27), 18947-18956, 2008
402008
Pilot phase I/II personalized therapy trial for metastatic colorectal cancer: evaluating the feasibility of protein pathway activation mapping for stratifying patients to …
M Pierobon, A Silvestri, A Spira, A Reeder, E Pin, S Banks, E Parasido, ...
Journal of proteome research 13 (6), 2846-2855, 2014
362014
Influence of eukaryotic translation initiation factor 6 on non–small cell lung cancer development and progression
N Gantenbein, E Bernhart, I Anders, N Golob-Schwarzl, S Krassnig, ...
European Journal of Cancer 101, 165-180, 2018
342018
A pilot characterization of human lung NSCLC by protein pathway activation mapping
A Zupa, G Improta, A Silvestri, E Pin, J Deng, M Aieta, P Musto, D Nitti, ...
Journal of Thoracic Oncology 7 (12), 1755-1766, 2012
342012
From chemotherapy to combined targeted therapeutics: in vitro and in vivo models to decipher intra-tumor heterogeneity
G Gambara, M Gaebler, U Keilholz, CRA Regenbrecht, A Silvestri
Frontiers in pharmacology 9, 77, 2018
262018
From chemotherapy to combined targeted therapeutics: in vitro and in vivo models to decipher intra-tumor heterogeneity
G Gambara, M Gaebler, U Keilholz, CRA Regenbrecht, A Silvestri
Frontiers in Pharmacology 9, 77, 2018
262018
Protein pathway activation mapping of colorectal metastatic progression reveals metastasis-specific network alterations
A Silvestri, V Calvert, C Belluco, M Lipsky, R De Maria, J Deng, ...
Clinical & experimental metastasis 30 (3), 309-316, 2013
252013
Reverse phase protein microarrays: fluorometric and colorimetric detection
RI Gallagher, A Silvestri, EF Petricoin, LA Liotta, V Espina
Protein Microarray for Disease Analysis, 275-301, 2011
252011
Protein drug target activation homogeneity in the face of intra-tumor heterogeneity: implications for precision medicine
EM Parasido, A Silvestri, V Canzonieri, C Belluco, MG Diodoro, M Milione, ...
Oncotarget 8 (30), 48534, 2017
102017
Academic collaborative models fostering the translation of physiological in vitro systems from basic research into drug discovery
A Silvestri, F Vicente, MJ Vicent, B Stechmann, W Fecke
Drug Discovery Today, 2021
62021
In Vitro Three-Dimensional Cell Cultures as Tool for Precision Medicine
A Silvestri, D Schumacher, M Silvestrov, R Schäfer, C Reinhard, ...
Mechanisms of Molecular Carcinogenesis–Volume 2, 281-313, 2017
62017
Use of gene expression signatures to identify origin of primary and therapeutic strategies for patients with advanced solid tumors.
SD Hsu, MK Kim, A Foye, A Silvestri, HK Lyerly, M Morse, E Petricoin III, ...
Journal of Clinical Oncology 28 (15_suppl), 10504-10504, 2010
32010
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