Amit U Sinha
Amit U Sinha
Instructor, Dana-Farber Cancer Inst and Harvard Medical School
Verified email at - Homepage
Cited by
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The Wnt/β-catenin pathway is required for the development of leukemia stem cells in AML
Y Wang, AV Krivtsov, AU Sinha, TE North, W Goessling, Z Feng, LI Zon, ...
Science 327 (5973), 1650-1653, 2010
MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L
KM Bernt, N Zhu, AU Sinha, S Vempati, J Faber, AV Krivtsov, Z Feng, ...
Cancer cell 20 (1), 66-78, 2011
Chromatin-modifying enzymes as modulators of reprogramming
TT Onder, N Kara, A Cherry, AU Sinha, N Zhu, KM Bernt, P Cahan, ...
Nature, 2012
Mapping human genetic diversity in Asia
HUGO Pan-Asian SNP Consortium, MA Abdulla, I Ahmed, ...
Science 326 (5959), 1541-1545, 2009
H3K79 methylation profiles define murine and human MLL-AF4 leukemias
AV Krivtsov, Z Feng, ME Lemieux, J Faber, S Vempati, AU Sinha, X Xia, ...
Cancer cell 14 (5), 355-368, 2008
Polycomb repressive complex 2 is required for MLL-AF9 leukemia
T Neff, AU Sinha, MJ Kluk, N Zhu, MH Khattab, L Stein, H Xie, SH Orkin, ...
Proceedings of the National Academy of Sciences, 2012
DOT1L inhibits SIRT1-mediated epigenetic silencing to maintain leukemic gene expression in MLL-rearranged leukemia
CW Chen, RP Koche, AU Sinha, AJ Deshpande, N Zhu, R Eng, ...
Nature medicine 21 (4), 335-343, 2015
Cell of origin determines clinically relevant subtypes of MLL-rearranged AML.
AV Krivtsov, ME Figueroa, AU Sinha, MC Stubbs, Z Feng, PJ Valk, ...
Leukemia: official journal of the Leukemia Society of America, Leukemia …, 2012
mTOR complex 1 plays critical roles in hematopoiesis and Pten-loss-evoked leukemogenesis
D Kalaitzidis, SM Sykes, Z Wang, N Punt, Y Tang, C Ragu, AU Sinha, ...
Cell stem cell 11 (3), 429-439, 2012
Mutations in epigenetic regulators including SETD2 are gained during relapse in paediatric acute lymphoblastic leukaemia
BG Mar, LB Bullinger, KM McLean, PV Grauman, MH Harris, K Stevenson, ...
Nature communications 5 (1), 1-6, 2014
Cinteny: flexible analysis and visualization of synteny and genome rearrangements in multiple organisms
AU Sinha, J Meller
Bmc Bioinformatics 8 (1), 82, 2007
Leukemic transformation by the MLL-AF6 fusion oncogene requires the H3K79 methyltransferase Dot1l.
AJ Deshpande, L Chen, M Fazio, AU Sinha, KM Bernt, D Banka, S Dias, ...
Blood, 2013
AF10 regulates progressive H3K79 methylation and HOX gene expression in diverse AML subtypes
AJ Deshpande, A Deshpande, AU Sinha, L Chen, J Chang, A Cihan, ...
Cancer cell 26 (6), 896-908, 2014
Haploinsufficiency of Dnmt1 impairs leukemia stem cell function through derepression of bivalent chromatin domains
JJ Trowbridge, AU Sinha, N Zhu, M Li, SA Armstrong, SH Orkin
Genes & Development 26 (4), 344-349, 2012
Targeting Chromatin Regulators Inhibits Leukemogenic Gene Expression in NPM1 Mutant Leukemia
MWM Kühn, E Song, Z Feng, A Sinha, CW Chen, AJ Deshpande, ...
Cancer discovery 6 (10), 1166-1181, 2016
NUP98 fusion proteins interact with the NSL and MLL1 complexes to drive leukemogenesis
H Xu, DG Valerio, ME Eisold, A Sinha, RP Koche, W Hu, CW Chen, ...
Cancer cell 30 (6), 863-878, 2016
MLL-AF9–and HOXA9-mediated acute myeloid leukemia stem cell self-renewal requires JMJD1C
N Zhu, M Chen, R Eng, J DeJong, AU Sinha, NF Rahnamay, R Koche, ...
The Journal of clinical investigation 126 (3), 997-1011, 2016
KMT2C mediates the estrogen dependence of breast cancer through regulation of ERα enhancer function
K Gala, Q Li, A Sinha, P Razavi, M Dorso, F Sanchez-Vega, YR Chung, ...
Oncogene 37 (34), 4692-4710, 2018
Dissecting microregulation of a master regulatory network
AU Sinha, V Kaimal, J Chen, A Jegga
BMC genomics 9 (1), 88, 2008
MLL1 and DOT1L cooperate with meningioma-1 to induce acute myeloid leukemia
SS Riedel, JN Haladyna, M Bezzant, B Stevens, DA Pollyea, AU Sinha, ...
The Journal of clinical investigation 126 (4), 1438-1450, 2016
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