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PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest J Liang, J Zubovitz, T Petrocelli, R Kotchetkov, MK Connor, K Han, JH Lee, ... Nature medicine 8 (10), 1153-1160, 2002 | 1235 | 2002 |
The Cdk inhibitor p27 in human cancer: prognostic potential and relevance to anticancer therapy IM Chu, L Hengst, JM Slingerland Nature Reviews Cancer 8 (4), 253-267, 2008 | 1158 | 2008 |
Multiple roles of the PI3K/PKB (Akt) pathway in cell cycle progression J Liang, JM Slingerland Cell cycle 2 (4), 336-342, 2003 | 1111 | 2003 |
Decreased levels of the cell-cycle inhibitor p27Kip1 protein: Prognostic implications in primary breast cancer C Catzavelos, N Bhattacharya, YC Ung, JA Wilson, L Roncari, C Sandhu, ... Nature medicine 3 (2), 227-230, 1997 | 1055 | 1997 |
The energy sensing LKB1–AMPK pathway regulates p27kip1 phosphorylation mediating the decision to enter autophagy or apoptosis J Liang, SH Shao, ZX Xu, B Hennessy, Z Ding, M Larrea, S Kondo, ... Nature cell biology 9 (2), 218-224, 2007 | 1006 | 2007 |
Regulation of the cdk inhibitor p27 and its deregulation in cancer J Slingerland, M Pagano Journal of cellular physiology 183 (1), 10-17, 2000 | 953 | 2000 |
Obesity and adverse breast cancer risk and outcome: Mechanistic insights and strategies for intervention M Picon‐Ruiz, C Morata‐Tarifa, JJ Valle‐Goffin, ER Friedman, ... CA: a cancer journal for clinicians 67 (5), 378-397, 2017 | 891 | 2017 |
Exosome transfer from stromal to breast cancer cells regulates therapy resistance pathways MC Boelens, TJ Wu, BY Nabet, B Xu, Y Qiu, T Yoon, DJ Azzam, ... Cell 159 (3), 499-513, 2014 | 809 | 2014 |
Skp2 is oncogenic and overexpressed in human cancers M Gstaiger, R Jordan, M Lim, C Catzavelos, J Mestan, J Slingerland, ... Proceedings of the National Academy of Sciences 98 (9), 5043-5048, 2001 | 695 | 2001 |
E-Cadherin–dependent Growth Suppression is Mediated by the Cyclin-dependent Kinase Inhibitor p27KIP1 B St. Croix, C Sheehan, JW Rak, VA Flørenes, JM Slingerland, RS Kerbel The Journal of cell biology 142 (2), 557-571, 1998 | 616 | 1998 |
Next-generation mTOR inhibitors in clinical oncology: how pathway complexity informs therapeutic strategy SA Wander, BT Hennessy, JM Slingerland The Journal of clinical investigation 121 (4), 1231-1241, 2011 | 501 | 2011 |
The prognostic significance of altered cyclin-dependent kinase inhibitors in human cancer J Tsihlias, MD, FRCSC, L Kapusta, MD, FRCPC, ... Annual review of medicine 50 (1), 401-423, 1999 | 462 | 1999 |
Loss of Cyclin-dependent Kinase Inhibitor p27Kip1 Is a Novel Prognostic Factor in Localized Human Prostate Adenocarcinoma J Tsihlias, LR Kapusta, G DeBoer, I Morava-Protzner, I Zbieranowski, ... Cancer research 58 (3), 542-548, 1998 | 458 | 1998 |
A novel inhibitor of cyclin-Cdk activity detected in transforming growth factor β-arrested epithelial cells JM Slingerland, L Hengst, CH Pan, D Alexander, MR Stampfer, SI Reed Molecular and Cellular Biology 14 (6), 3683-3694, 1994 | 442 | 1994 |
p27 phosphorylation by Src regulates inhibition of cyclin E-Cdk2 I Chu, J Sun, A Arnaout, H Kahn, W Hanna, S Narod, P Sun, CK Tan, ... Cell 128 (2), 281-294, 2007 | 433 | 2007 |
A cell cycle-regulated inhibitor of cyclin-dependent kinases. L Hengst, V Dulic, JM Slingerland, E Lees, SI Reed Proceedings of the National Academy of Sciences 91 (12), 5291-5295, 1994 | 396 | 1994 |
Overexpression of the integrin-linked kinase promotes anchorage-independent cell cycle progression G Radeva, T Petrocelli, E Behrend, C Leung-Hagesteijn, J Filmus, ... Journal of biological chemistry 272 (21), 13937-13944, 1997 | 368 | 1997 |
Impact of the cyclin-dependent kinase inhibitor p27Kip1 on resistance of tumor cells to anticancer agents. B St Croix, VA Flørenes, JW Rak, M Flanagan, N Bhattacharya, ... Nature medicine 2 (11), 1204-1210, 1996 | 356 | 1996 |
Cytokines, obesity, and cancer: new insights on mechanisms linking obesity to cancer risk and progression CA Gilbert, JM Slingerland Annual review of medicine 64, 45-57, 2013 | 342 | 2013 |