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Simon Leedham
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Oncostatin M drives intestinal inflammation and predicts response to tumor necrosis factor–neutralizing therapy in patients with inflammatory bowel disease
NR West, AN Hegazy, BMJ Owens, SJ Bullers, B Linggi, S Buonocore, ...
Nature medicine 23 (5), 579-589, 2017
6522017
Mitochondrial DNA mutations are established in human colonic stem cells, and mutated clones expand by crypt fission
LC Greaves, SL Preston, PJ Tadrous, RW Taylor, MJ Barron, D Oukrif, ...
Proceedings of the National Academy of Sciences 103 (3), 714-719, 2006
3282006
Hereditary mixed polyposis syndrome is caused by a 40-kb upstream duplication that leads to increased and ectopic expression of the BMP antagonist GREM1
E Jaeger, S Leedham, A Lewis, S Segditsas, M Becker, PR Cuadrado, ...
Nature genetics 44 (6), 699-703, 2012
2882012
British Society of Gastroenterology position statement on serrated polyps in the colon and rectum
JE East, WS Atkin, AC Bateman, SK Clark, S Dolwani, SN Ket, ...
Gut 66 (7), 1181-1196, 2017
2852017
Mechanisms of field cancerization in the human stomach: the expansion and spread of mutated gastric stem cells
SAC McDonald, LC Greaves, L Gutierrez–Gonzalez, M Rodriguez–Justo, ...
Gastroenterology 134 (2), 500-510, 2008
2852008
Aberrant epithelial GREM1 expression initiates colonic tumorigenesis from cells outside the stem cell niche
H Davis, S Irshad, M Bansal, H Rafferty, T Boitsova, C Bardella, E Jaeger, ...
Nature medicine 21 (1), 62-70, 2015
2762015
Individual crypt genetic heterogeneity and the origin of metaplastic glandular epithelium in human Barrett’s oesophagus
SJ Leedham, SL Preston, SAC McDonald, G Elia, P Bhandari, D Poller, ...
Gut 57 (8), 1041-1048, 2008
2582008
Intestinal stem cells
SJ Leedham, M Brittan, SAC McDonald, NA Wright
Journal of cellular and molecular medicine 9 (1), 11-24, 2005
2142005
Clonality, founder mutations, and field cancerization in human ulcerative colitis–associated neoplasia
SJ Leedham, TA Graham, D Oukrif, SAC McDonald, M Rodriguez–Justo, ...
Gastroenterology 136 (2), 542-550. e6, 2009
2032009
Association analyses identify 31 new risk loci for colorectal cancer susceptibility
PJ Law, M Timofeeva, C Fernandez-Rozadilla, P Broderick, J Studd, ...
Nature communications 10 (1), 2154, 2019
2012019
Image-based consensus molecular subtype (imCMS) classification of colorectal cancer using deep learning
K Sirinukunwattana, E Domingo, SD Richman, KL Redmond, A Blake, ...
Gut 70 (3), 544-554, 2021
1732021
Clonality assessment and clonal ordering of individual neoplastic crypts shows polyclonality of colorectal adenomas
C Thirlwell, OCC Will, E Domingo, TA Graham, SAC McDonald, D Oukrif, ...
Gastroenterology 138 (4), 1441-1454. e7, 2010
1652010
NOTUM from Apc-mutant cells biases clonal competition to initiate cancer
DJ Flanagan, N Pentinmikko, K Luopajärvi, NJ Willis, K Gilroy, AP Raven, ...
Nature 594 (7863), 430-435, 2021
1352021
Evolutionary history of human colitis-associated colorectal cancer
AM Baker, W Cross, K Curtius, I Al Bakir, CHR Choi, HL Davis, D Temko, ...
Gut 68 (6), 985-995, 2019
1342019
The safety of autologous fat transfer in breast cancer: lessons from stem cell biology
RA Pearl, SJ Leedham, MD Pacifico
Journal of plastic, reconstructive & aesthetic surgery 65 (3), 283-288, 2012
1322012
Field cancerization in the intestinal epithelium of patients with Crohn's ileocolitis
S Galandiuk, M Rodriguez–Justo, R Jeffery, AM Nicholson, Y Cheng, ...
Gastroenterology 142 (4), 855-864. e8, 2012
1262012
Inflammatory bowel disease and colon cancer
N Jawad, N Direkze, SJ Leedham
Inflammation and Gastrointestinal Cancers, 99-115, 2011
1162011
The evolutionary landscape of colorectal tumorigenesis
W Cross, M Kovac, V Mustonen, D Temko, H Davis, AM Baker, S Biswas, ...
Nature ecology & evolution 2 (10), 1661-1672, 2018
1142018
The clonal origins of dysplasia from intestinal metaplasia in the human stomach
L Gutierrez–Gonzalez, TA Graham, M Rodriguez–Justo, SJ Leedham, ...
Gastroenterology 140 (4), 1251-1260. e6, 2011
1142011
CD161 defines a functionally distinct subset of pro-inflammatory natural killer cells
A Kurioka, C Cosgrove, Y Simoni, A Geremia, S Björkander, ...
Frontiers in immunology 9, 312468, 2018
1122018
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